10.46243/jst.2025.v10.i6.pp62-82 registered
Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction
Resolves to https://www.jst.org.in/index.php/pub/article/view/1379
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2025.v10.i6.pp62-82
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 02d6723331fd0930…
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What the DOI identifies
JournalArticle — an article in a journal · Digital · Visual · en
Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction (PrincipalTitle)
Published 2025-06-24
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 10 · issue 06 · pages 62–82
Agents
- Dr. B. ARUNA (author)
- DR.M.SPURTHIMITHRA (author)
- DR C.RENUKATEJASWINI (author)
- DR M SRIRAMACHANDRA (author)
- DR S.RAJESHRAJA (author)
- DR S.RAJESHRAJA (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2025.v10.i6.pp62-82
Abstract
Histologic features shared by primary human hepatocytes are maintained by proliferating hepatocytes from the human upcyte® line. The use of four donors' second-generation upcyte® hepatocytes in inhibition and induction tests with a variety of reference inhibitors and inducers was thoroughly evaluated. Reproducible inhibition of CYP1A2, CYP2B6, CYP2C9, and CYP3A4 occurred at concentrations ranging from very low to very high, and the IC50 values computed for each chemical accurately designated them as powerful inhibitors.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2025.v10.i6.pp62-82 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: Dr. B. ARUNA author: DR.M.SPURTHIMITHRA author: DR C.RENUKATEJASWINI author: DR M SRIRAMACHANDRA author: DR S.RAJESHRAJA author: DR S.RAJESHRAJA publisher: Longman Publishers published: 2025-06-24 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 10 · no. 06 · pp. 62–82 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-08-27 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
complete Every System Metadata element is here, with the basic metadata a journal article needs.
The System Metadata Declaration (JSON) · the Kernel Metadata Declaration (XML) · what each sub-type needs
History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 160 fields set · sha256 8f25134e1736… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
Machine-readable: the history as JSON, with the full record after each change.
