Cite this DOI

Dr. B. ARUNA, DR.M.SPURTHIMITHRA, DR C.RENUKATEJASWINI, DR M SRIRAMACHANDRA, DR S.RAJESHRAJA, & DR S.RAJESHRAJA (2025). Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction. *Journal of Science & Technology*, *10*(06), 62–82. https://doi.org/10.46243/jst.2025.v10.i6.pp62-82

@article{drbaruna2025human,
  author    = {Dr. B. ARUNA and DR.M.SPURTHIMITHRA and DR C.RENUKATEJASWINI and DR M SRIRAMACHANDRA and DR S.RAJESHRAJA and DR S.RAJESHRAJA},
  title     = {{Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction}},
  journal   = {Journal of Science \& Technology},
  year      = {2025},
  month     = {jun},
  volume    = {10},
  number    = {06},
  pages     = {62--82},
  publisher = {Longman Publishers},
  issn      = {2456-5660},
  doi       = {10.46243/jst.2025.v10.i6.pp62-82},
  url       = {https://doi.org/10.46243/jst.2025.v10.i6.pp62-82},
  language  = {en},
  abstract  = {Histologic features shared by primary human hepatocytes are maintained by proliferating hepatocytes from the human upcyte® line. The use of four donors' second-generation upcyte® hepatocytes in inhibition and induction tests with a variety of reference inhibitors and inducers was thoroughly evaluated. Reproducible inhibition of CYP1A2, CYP2B6, CYP2C9, and CYP3A4 occurred at concentrations ranging from very low to very high, and the IC50 values computed for each chemical accurately designated them as powerful inhibitors.}
}

TY  - JOUR
TI  - Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction
AU  - Dr. B. ARUNA
AU  - DR.M.SPURTHIMITHRA
AU  - DR C.RENUKATEJASWINI
AU  - DR M SRIRAMACHANDRA
AU  - DR S.RAJESHRAJA
AU  - DR S.RAJESHRAJA
JO  - Journal of Science & Technology
PY  - 2025
DA  - 2025/06/24/
VL  - 10
IS  - 06
SP  - 62
EP  - 82
PB  - Longman Publishers
SN  - 2456-5660
LA  - en
AB  - Histologic features shared by primary human hepatocytes are maintained by proliferating hepatocytes from the human upcyte® line. The use of four donors' second-generation upcyte® hepatocytes in inhibition and induction tests with a variety of reference inhibitors and inducers was thoroughly evaluated. Reproducible inhibition of CYP1A2, CYP2B6, CYP2C9, and CYP3A4 occurred at concentrations ranging from very low to very high, and the IC50 values computed for each chemical accurately designated them as powerful inhibitors.
DO  - 10.46243/jst.2025.v10.i6.pp62-82
UR  - https://doi.org/10.46243/jst.2025.v10.i6.pp62-82
ER  -

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    "id": "10.46243/jst.2025.v10.i6.pp62-82",
    "DOI": "10.46243/jst.2025.v10.i6.pp62-82",
    "URL": "https://doi.org/10.46243/jst.2025.v10.i6.pp62-82",
    "title": "Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction",
    "source": "Smart Scholars DOI Registry",
    "container-title": "Journal of Science & Technology",
    "author": [
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            "family": "DR.M.SPURTHIMITHRA"
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            "family": "DR C.RENUKATEJASWINI"
        },
        {
            "family": "DR M SRIRAMACHANDRA"
        },
        {
            "family": "DR S.RAJESHRAJA"
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            "family": "DR S.RAJESHRAJA"
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    "issued": {
        "date-parts": [
            [
                2025,
                6,
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    "volume": "10",
    "issue": "06",
    "page": "62-82",
    "publisher": "Longman Publishers",
    "language": "en",
    "abstract": "Histologic features shared by primary human hepatocytes are maintained by proliferating hepatocytes from the human upcyte® line. The use of four donors' second-generation upcyte® hepatocytes in inhibition and induction tests with a variety of reference inhibitors and inducers was thoroughly evaluated. Reproducible inhibition of CYP1A2, CYP2B6, CYP2C9, and CYP3A4 occurred at concentrations ranging from very low to very high, and the IC50 values computed for each chemical accurately designated them as powerful inhibitors.",
    "ISSN": "2456-5660"
}

From the record as registered (version 2) — the record and its history. Programs: https://registry.smartscholars.in/api.php?action=cite&doi=10.46243%2Fjst.2025.v10.i6.pp62-82 gives all four in one JSON answer.