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Eur J Med Chem 57: 441–" }, { "path": "references.4.doi", "from": null, "to": "10.2165/00128415-201214100-00010" }, { "path": "references.4.key", "from": null, "to": "ref5" }, { "path": "references.4.unstructured", "from": null, "to": "EMA (2012). Guideline on the investigation of drug interactions. 21 June 2012, CPMP/ EWP/560/95/Rev. 1 Corr. 2, Committee for Human Medicinal Products (CHMP) http:// www.ema.europa.eu/docs/en_GB/document_ library/ Scientific_guideline/2012/07/ WC500129606.pdf" }, { "path": "references.5.doi", "from": null, "to": "10.2133/dmpk.20.351" }, { "path": "references.5.key", "from": null, "to": "ref6" }, { "path": "references.5.unstructured", "from": null, "to": "Emoto C, Murase S, Sawada Y, Iwasaki K (2005). B. ARUNA, M.SPURTHIMITHRA, C. 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Drug Metab Dispos 36: 1971–1974" }, { "path": "references.7.doi", "from": null, "to": "10.1124/dmd.32.3.348" }, { "path": "references.7.key", "from": null, "to": "ref8" }, { "path": "references.7.unstructured", "from": null, "to": "Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, et al. (2004). Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos 32: 348–358" }, { "path": "references.8.doi", "from": null, "to": "10.1124/jpet.106.112136" }, { "path": "references.8.key", "from": null, "to": "ref9" }, { "path": "references.8.unstructured", "from": null, "to": "Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, et al. (2007). Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. 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Guidance for industry: drug interaction studies—study design, data analysis, implications for dosing, and labeling recommendations (Research CfDEa ed). http:// www.fda.gov/downloads/drugs/ guidancecomplianceregulatory information/ guidances/ucm292362.pdf" }, { "path": "referent", "from": null, "to": "Creation" }, { "path": "structural_type", "from": null, "to": "Digital" }, { "path": "titles.0.lang", "from": null, "to": "en" }, { "path": "titles.0.type", "from": null, "to": "PrincipalTitle" }, { "path": "titles.0.value", "from": null, "to": "Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction" }, { "path": "type", "from": null, "to": "JournalArticle" } ], "record_after": { "format": "smartscholars-doi-metadata/1.0", "doi": "10.46243/jst.2025.v10.i6.pp62-82", "referent": "Creation", "type": "JournalArticle", "structural_type": "Digital", "modes": [ "Visual" ], "characters": [ "Language" ], "titles": [ { "value": "Use of human hepatocytes from the second generation of the upcyte® brand in investigations of CYP inhibition and induction", "type": "PrincipalTitle", "lang": "en" } ], "identifiers": [ { "type": "DOI", "value": "10.46243/jst.2025.v10.i6.pp62-82" } ], "agents": [ { "role": "author", "name": { "given": "", "family": "Dr. B. 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The use of four donors' second-generation upcyte® hepatocytes in inhibition and induction tests with a variety of reference inhibitors and inducers was thoroughly evaluated. Reproducible inhibition of CYP1A2, CYP2B6, CYP2C9, and CYP3A4 occurred at concentrations ranging from very low to very high, and the IC50 values computed for each chemical accurately designated them as powerful inhibitors.", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2025-06-24", "applies_to": "vor" }, "references": [ { "key": "ref1", "doi": "10.1124/dmd.109.030197", "unstructured": "Antherieu S, Chesne C, Li R, Camus S, Lahoz A, Picazo L, et al. (2010). Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos 38: 516–525" }, { "key": "ref2", "doi": "10.3109/00498254.2012.675093", "unstructured": "Burkard A, Dahn C, Heinz S, Zutavern A, Sonntag-Buck V, Maltman D, et al. (2012). 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The use of four donors' second-generation upcyte® hepatocytes in inhibition and induction tests with a variety of reference inhibitors and inducers was thoroughly evaluated. Reproducible inhibition of CYP1A2, CYP2B6, CYP2C9, and CYP3A4 occurred at concentrations ranging from very low to very high, and the IC50 values computed for each chemical accurately designated them as powerful inhibitors.", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2025-06-24", "applies_to": "vor" }, "references": [ { "key": "ref1", "doi": "10.1124/dmd.109.030197", "unstructured": "Antherieu S, Chesne C, Li R, Camus S, Lahoz A, Picazo L, et al. (2010). Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos 38: 516–525" }, { "key": "ref2", "doi": "10.3109/00498254.2012.675093", "unstructured": "Burkard A, Dahn C, Heinz S, Zutavern A, Sonntag-Buck V, Maltman D, et al. (2012). 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