10.46243/jst.2021.v6.i05.pp39-63 registered
A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis
Resolves to https://www.jst.org.in/index.php/pub/article/view/932
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2021.v6.i05.pp39-63
Registered 29 Sep 2026 via crossref · record version 2 · last change 30 Sep 2026, 12:00 AM · record sha256 19cca9bb6eeb0a6c…
Resolve ⬇ Record (JSON) ⬇ Kernel Metadata Declaration (XML) Compare with Crossref Cite (APA · BibTeX · RIS · CSL)
What the DOI identifies
JournalArticle — an article in a journal · Digital · Visual · en
A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis (PrincipalTitle)
Published 2021-10-05
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 06 · issue 05 · pages 39–63
Agents
- Sriragavi Ravi (author)
- Rajagopal Ayyanar (author)
- Nalini Namasivayam (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2021.v6.i05.pp39-63
Abstract
p- Methoxycinnamic acid (p-MCA), an active phenolic compound derived from the rice bran, turmeric and Kaempferia galangal, is known to exhibit numerous pharmacological properties. We investigated that chemopreventive effect of p-MCA against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in male wistar rats. Rats were subjectively divided into five groups. Group 1 served as control and was fed modified pellet diet and water. Group 2 received the reference drug (Sorafenib [11.4 mg/kg b.w]). Group 3, 4 and 5 rats received the hepatocarcinogen (NDEA) intraperitoneally in addition to 2-acetylaminofluorene (AAF) as promotor. In addition group 4 rats received p-MCA at the dose of 80 mg/kg b.w. and group 5 rats received sorafenib at the dose of 11.4 mg/kg b.w throughout the experimental period. Our results established that supplementation with p-MCA and the reference drug (sorafenib) to NDEA induced rats significantly decreased the incidence of cancer in the liver, besides altering the phase I and phase II xenobiotic enzymes. Furthermore the increased expressions of collagen, lipid and glycogen accumulation observed in NDEA alone-induced rats were comparable with those of the control rats, p-MCA and sorafenib alone treated rats. Our results proved that p-MCA was equally effective that of the reference drug sorafenib (which is used currently for the treatment of hepatocellular carcinoma against NDEA induced hepatocarcinogenesis
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2021.v6.i05.pp39-63 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: Sriragavi Ravi author: Rajagopal Ayyanar author: Nalini Namasivayam publisher: Longman Publishers published: 2021-10-05 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 06 · no. 05 · pp. 39–63 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-09-12 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
complete Every System Metadata element is here, with the basic metadata a journal article needs.
The System Metadata Declaration (JSON) · the Kernel Metadata Declaration (XML) · what each sub-type needs
History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 210 fields set · sha256 6afa1e32d8ef… |
| 2 | 30 Sep 2026, 12:00 AM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
Machine-readable: the history as JSON, with the full record after each change.
