Cite this DOI
10.46243/jst.2021.v6.i05.pp39-63 · A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis
APA (7th edition)
Ravi, S., Ayyanar, R., & Namasivayam, N. (2021). A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis. *Journal of Science & Technology*, *06*(05), 39–63. https://doi.org/10.46243/jst.2021.v6.i05.pp39-63
⬇ text Italics are shown as *asterisks* in plain text — the journal or book title and the volume.
BibTeX
@article{ravi2021long,
author = {Ravi, Sriragavi and Ayyanar, Rajagopal and Namasivayam, Nalini},
title = {{A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis}},
journal = {Journal of Science \& Technology},
year = {2021},
month = {oct},
volume = {06},
number = {05},
pages = {39--63},
publisher = {Longman Publishers},
issn = {2456-5660},
doi = {10.46243/jst.2021.v6.i05.pp39-63},
url = {https://doi.org/10.46243/jst.2021.v6.i05.pp39-63},
language = {en},
abstract = {p- Methoxycinnamic acid (p-MCA), an active phenolic compound derived from the rice bran, turmeric and Kaempferia galangal, is known to exhibit numerous pharmacological properties. We investigated that chemopreventive effect of p-MCA against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in male wistar rats. Rats were subjectively divided into five groups. Group 1 served as control and was fed modified pellet diet and water. Group 2 received the reference drug (Sorafenib [11.4 mg/kg b.w]). Group 3, 4 and 5 rats received the hepatocarcinogen (NDEA) intraperitoneally in addition to 2-acetylaminofluorene (AAF) as promotor. In addition group 4 rats received p-MCA at the dose of 80 mg/kg b.w. and group 5 rats received sorafenib at the dose of 11.4 mg/kg b.w throughout the experimental period. Our results established that supplementation with p-MCA and the reference drug (sorafenib) to NDEA induced rats significantly decreased the incidence of cancer in the liver, besides altering the phase I and phase II xenobiotic enzymes. Furthermore the increased expressions of collagen, lipid and glycogen accumulation observed in NDEA alone-induced rats were comparable with those of the control rats, p-MCA and sorafenib alone treated rats. Our results proved that p-MCA was equally effective that of the reference drug sorafenib (which is used currently for the treatment of hepatocellular carcinoma against NDEA induced hepatocarcinogenesis}
}RIS (EndNote, Zotero, Mendeley)
TY - JOUR TI - A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis AU - Ravi, Sriragavi AU - Ayyanar, Rajagopal AU - Namasivayam, Nalini JO - Journal of Science & Technology PY - 2021 DA - 2021/10/05/ VL - 06 IS - 05 SP - 39 EP - 63 PB - Longman Publishers SN - 2456-5660 LA - en AB - p- Methoxycinnamic acid (p-MCA), an active phenolic compound derived from the rice bran, turmeric and Kaempferia galangal, is known to exhibit numerous pharmacological properties. We investigated that chemopreventive effect of p-MCA against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in male wistar rats. Rats were subjectively divided into five groups. Group 1 served as control and was fed modified pellet diet and water. Group 2 received the reference drug (Sorafenib [11.4 mg/kg b.w]). Group 3, 4 and 5 rats received the hepatocarcinogen (NDEA) intraperitoneally in addition to 2-acetylaminofluorene (AAF) as promotor. In addition group 4 rats received p-MCA at the dose of 80 mg/kg b.w. and group 5 rats received sorafenib at the dose of 11.4 mg/kg b.w throughout the experimental period. Our results established that supplementation with p-MCA and the reference drug (sorafenib) to NDEA induced rats significantly decreased the incidence of cancer in the liver, besides altering the phase I and phase II xenobiotic enzymes. Furthermore the increased expressions of collagen, lipid and glycogen accumulation observed in NDEA alone-induced rats were comparable with those of the control rats, p-MCA and sorafenib alone treated rats. Our results proved that p-MCA was equally effective that of the reference drug sorafenib (which is used currently for the treatment of hepatocellular carcinoma against NDEA induced hepatocarcinogenesis DO - 10.46243/jst.2021.v6.i05.pp39-63 UR - https://doi.org/10.46243/jst.2021.v6.i05.pp39-63 ER -
CSL-JSON
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"abstract": "p- Methoxycinnamic acid (p-MCA), an active phenolic compound derived from the rice bran, turmeric and Kaempferia galangal, is known to exhibit numerous pharmacological properties. We investigated that chemopreventive effect of p-MCA against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in male wistar rats. Rats were subjectively divided into five groups. Group 1 served as control and was fed modified pellet diet and water. Group 2 received the reference drug (Sorafenib [11.4 mg/kg b.w]). Group 3, 4 and 5 rats received the hepatocarcinogen (NDEA) intraperitoneally in addition to 2-acetylaminofluorene (AAF) as promotor. In addition group 4 rats received p-MCA at the dose of 80 mg/kg b.w. and group 5 rats received sorafenib at the dose of 11.4 mg/kg b.w throughout the experimental period. Our results established that supplementation with p-MCA and the reference drug (sorafenib) to NDEA induced rats significantly decreased the incidence of cancer in the liver, besides altering the phase I and phase II xenobiotic enzymes. Furthermore the increased expressions of collagen, lipid and glycogen accumulation observed in NDEA alone-induced rats were comparable with those of the control rats, p-MCA and sorafenib alone treated rats. Our results proved that p-MCA was equally effective that of the reference drug sorafenib (which is used currently for the treatment of hepatocellular carcinoma against NDEA induced hepatocarcinogenesis",
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} ⬇ .json What citeproc and reference managers read; the DOI system hands it out for Accept: application/vnd.citationstyles.csl+json, and so does this registry's resolver.
From the record as registered (version 2) — the record and its history. Programs: https://registry.smartscholars.in/api.php?action=cite&doi=10.46243%2Fjst.2021.v6.i05.pp39-63 gives all four in one JSON answer.
