{ "ok": true, "doi": "10.46243/jst.2021.v6.i05.pp39-63", "events": [ { "seq": 1, "kind": "register", "at": "2026-09-29 22:00:41", "by": "Administrator (admin)", "by_kind": "user", "note": "registered at Crossref; record read from api.crossref.org", "changes": [ { "path": "abstract.lang", "from": null, "to": "en" }, { "path": "abstract.value", "from": null, "to": "p- Methoxycinnamic acid (p-MCA), an active phenolic compound derived from the rice bran, turmeric and Kaempferia galangal, is known to exhibit numerous pharmacological properties. We investigated that chemopreventive effect of p-MCA against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in male wistar rats. Rats were subjectively divided into five groups. Group 1 served as control and was fed modified pellet diet and water. Group 2 received the reference drug (Sorafenib [11.4 mg/kg b.w]). Group 3, 4 and 5 rats received the hepatocarcinogen (NDEA) intraperitoneally in addition to 2-acetylaminofluorene (AAF) as promotor. In addition group 4 rats received p-MCA at the dose of 80 mg/kg b.w. and group 5 rats received sorafenib at the dose of 11.4 mg/kg b.w throughout the experimental period. Our results established that supplementation with p-MCA and the reference drug (sorafenib) to NDEA induced rats significantly decreased the incidence of cancer in the liver, besides altering the phase I and phase II xenobiotic enzymes. Furthermore the increased expressions of collagen, lipid and glycogen accumulation observed in NDEA alone-induced rats were comparable with those of the control rats, p-MCA and sorafenib alone treated rats. 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(2002) 35:1281–1291" }, { "path": "referent", "from": null, "to": "Creation" }, { "path": "structural_type", "from": null, "to": "Digital" }, { "path": "titles.0.lang", "from": null, "to": "en" }, { "path": "titles.0.type", "from": null, "to": "PrincipalTitle" }, { "path": "titles.0.value", "from": null, "to": "A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis" }, { "path": "type", "from": null, "to": "JournalArticle" } ], "record_after": { "format": "smartscholars-doi-metadata/1.0", "doi": "10.46243/jst.2021.v6.i05.pp39-63", "referent": "Creation", "type": "JournalArticle", "structural_type": "Digital", "modes": [ "Visual" ], "characters": [ "Language" ], "titles": [ { "value": "A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis", "type": "PrincipalTitle", "lang": "en" } ], "identifiers": [ { "type": "DOI", "value": "10.46243/jst.2021.v6.i05.pp39-63" } ], "agents": [ { "role": "author", "name": { "given": "Sriragavi", "family": "Ravi" }, "sequence": "first" }, { "role": "author", "name": { "given": "Rajagopal", "family": "Ayyanar" }, "sequence": "additional" }, { "role": "author", "name": { "given": "Nalini", "family": "Namasivayam" }, "sequence": "additional" }, { "role": "publisher", "name": { "org": "Longman Publishers" } } ], "dates": { "published": "2021-10-05", "date_type": "PublicationDate", "online": "2021-10-05" }, "language": "en", "container": { "type": "Journal", "titles": [ { "value": "Journal of Science & Technology", "type": "PrincipalTitle" } ], "identifiers": [ { "type": "ISSN", "value": "2456-5660", "medium": "electronic" } ], "volume": "06", "issue": "05", "pages": { "first": "39", "last": "63" } }, "links": [ { "url": "https://www.jst.org.in/index.php/pub/article/view/932", "return_type": "text/html", "primary": true }, { "url": "https://www.jst.org.in/index.php/pub/article/download/932/859", "purpose": "text-mining", "return_type": "application/pdf" }, { "url": "https://www.jst.org.in/index.php/pub/article/download/932/2558", "purpose": "text-mining", "return_type": "application/xml" }, { "url": "https://www.jst.org.in/index.php/pub/article/view/932/859", "purpose": "similarity-checking" } ], "abstract": { "value": "p- Methoxycinnamic acid (p-MCA), an active phenolic compound derived from the rice bran, turmeric and Kaempferia galangal, is known to exhibit numerous pharmacological properties. We investigated that chemopreventive effect of p-MCA against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in male wistar rats. Rats were subjectively divided into five groups. Group 1 served as control and was fed modified pellet diet and water. Group 2 received the reference drug (Sorafenib [11.4 mg/kg b.w]). Group 3, 4 and 5 rats received the hepatocarcinogen (NDEA) intraperitoneally in addition to 2-acetylaminofluorene (AAF) as promotor. In addition group 4 rats received p-MCA at the dose of 80 mg/kg b.w. and group 5 rats received sorafenib at the dose of 11.4 mg/kg b.w throughout the experimental period. Our results established that supplementation with p-MCA and the reference drug (sorafenib) to NDEA induced rats significantly decreased the incidence of cancer in the liver, besides altering the phase I and phase II xenobiotic enzymes. Furthermore the increased expressions of collagen, lipid and glycogen accumulation observed in NDEA alone-induced rats were comparable with those of the control rats, p-MCA and sorafenib alone treated rats. Our results proved that p-MCA was equally effective that of the reference drug sorafenib (which is used currently for the treatment of hepatocellular carcinoma against NDEA induced hepatocarcinogenesis", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2021-10-05", "applies_to": "vor" }, "references": [ { "key": "ref1", "doi": "10.1186/s12906-017-1926-6", "unstructured": "Fazal Khan, Tariq Jamal Khan, Gauthaman Kalamegam, Peter Natesan Pushparaj, Adeel Chaudhary,Adel Abuzenadah, Taha Kumosani, Elie Barbour and Mohammed Al-Qahtani. Anticancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. BMC Complementary and Alternative Medicine. 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We investigated that chemopreventive effect of p-MCA against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in male wistar rats. Rats were subjectively divided into five groups. Group 1 served as control and was fed modified pellet diet and water. Group 2 received the reference drug (Sorafenib [11.4 mg/kg b.w]). Group 3, 4 and 5 rats received the hepatocarcinogen (NDEA) intraperitoneally in addition to 2-acetylaminofluorene (AAF) as promotor. In addition group 4 rats received p-MCA at the dose of 80 mg/kg b.w. and group 5 rats received sorafenib at the dose of 11.4 mg/kg b.w throughout the experimental period. Our results established that supplementation with p-MCA and the reference drug (sorafenib) to NDEA induced rats significantly decreased the incidence of cancer in the liver, besides altering the phase I and phase II xenobiotic enzymes. Furthermore the increased expressions of collagen, lipid and glycogen accumulation observed in NDEA alone-induced rats were comparable with those of the control rats, p-MCA and sorafenib alone treated rats. Our results proved that p-MCA was equally effective that of the reference drug sorafenib (which is used currently for the treatment of hepatocellular carcinoma against NDEA induced hepatocarcinogenesis", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2021-10-05", "applies_to": "vor" }, "references": [ { "key": "ref1", "doi": "10.1186/s12906-017-1926-6", "unstructured": "Fazal Khan, Tariq Jamal Khan, Gauthaman Kalamegam, Peter Natesan Pushparaj, Adeel Chaudhary,Adel Abuzenadah, Taha Kumosani, Elie Barbour and Mohammed Al-Qahtani. Anticancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. BMC Complementary and Alternative Medicine. 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