10.46243/jst.2025.v10.i7.pp13-28 registered
Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation
Resolves to https://www.jst.org.in/index.php/pub/article/view/1375
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2025.v10.i7.pp13-28
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 94a1b093fd2cd6d5…
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JournalArticle — an article in a journal · Digital · Visual · en
Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation (PrincipalTitle)
Published 2025-07-01
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 10 · issue 07 · pages 13–28
Agents
- K.SARASIRISHA (author)
- D CHAITANYA DIXIT (author)
- P.T.NAGARAJU (author)
- B Akhila (author)
- E Nagadeepthi (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2025.v10.i7.pp13-28
Abstract
It is crucial for sustainable pharmaceutical analysis to develop two environmentally friendly analytical methods that can simultaneously determine eight cardiovascular drugs: hydrochlorothiazide (HCT), captopril (CPL), lisinopril (LSP), valsartan (VAL), atorvastatin (ATR), bisoprolol (BSL), amlodipine (AML), and carvedilol (CVL). Additionally, the nutraceutical vincamine (VIC) should be tested. Micellar Electro Kinetic Chromatography (MEKC) and High-Performance Liquid Chromatography (HPLC) are investigated in this work as potential tools for this objective. The MEKC technique separates substances by using fused silica capillaries with an internal diameter of 41.5 cm and a background electrolyte that includes 50 mM borate buffer with a pH of 9, 50 mM sodium lauryl sulfate (SLS), and 10% Acetonitrile. A ZORBAX Extend- C18 column, measuring 4.6 × 250 mm and having a particle size of 5 µm, was used for separation in the HPLC technique. The mobile phase, which consisted of methanol and 50 mM phosphate buffer pH 3, was used in the gradient. With minimal values of LOD and LOQ, both techniques achieved high linearity (r > 0.9996). Both approaches were effective in identifying the examined medications’ co-administered single, binary, and ternary dose forms. As an added bonus, different combinations of co-administered dose forms in rat plasma, proving the techniques’ viability in various matrices. In line with green chemistry principles, micellar solutions are used in MEKC to increase separation efficiency and decrease organic solvent use. To minimize toxicity and waste, HPLC procedures were fine-tuned utilizing solvents that are safe for the environment. To make sure the approaches were completely sustainable, we looked at their ecological effect, safety, and practical efficiency using green, white, and blue criteria. The techniques were perfect for frequent usage in pharmaceutical analysis since they were costeffective, time-saving, and attained excellent efficiency, sensitivity, and repeatability
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Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2025.v10.i7.pp13-28 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: K.SARASIRISHA author: D CHAITANYA DIXIT author: P.T.NAGARAJU author: B Akhila author: E Nagadeepthi publisher: Longman Publishers published: 2025-07-01 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 10 · no. 07 · pp. 13–28 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-08-27 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
complete Every System Metadata element is here, with the basic metadata a journal article needs.
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History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 162 fields set · sha256 0731c319c66b… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
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