Cite this DOI
10.46243/jst.2025.v10.i7.pp13-28 · Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation
APA (7th edition)
K.SARASIRISHA, D CHAITANYA DIXIT, P.T.NAGARAJU, B Akhila, & E Nagadeepthi (2025). Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation. *Journal of Science & Technology*, *10*(07), 13–28. https://doi.org/10.46243/jst.2025.v10.i7.pp13-28
⬇ text Italics are shown as *asterisks* in plain text — the journal or book title and the volume.
BibTeX
@article{ksarasirisha2025analyzing,
author = {K.SARASIRISHA and D CHAITANYA DIXIT and P.T.NAGARAJU and B Akhila and E Nagadeepthi},
title = {{Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation}},
journal = {Journal of Science \& Technology},
year = {2025},
month = {jul},
volume = {10},
number = {07},
pages = {13--28},
publisher = {Longman Publishers},
issn = {2456-5660},
doi = {10.46243/jst.2025.v10.i7.pp13-28},
url = {https://doi.org/10.46243/jst.2025.v10.i7.pp13-28},
language = {en},
abstract = {It is crucial for sustainable pharmaceutical analysis to develop two environmentally friendly analytical methods that can simultaneously determine eight cardiovascular drugs: hydrochlorothiazide (HCT), captopril (CPL), lisinopril (LSP), valsartan (VAL), atorvastatin (ATR), bisoprolol (BSL), amlodipine (AML), and carvedilol (CVL). Additionally, the nutraceutical vincamine (VIC) should be tested. Micellar Electro Kinetic Chromatography (MEKC) and High-Performance Liquid Chromatography (HPLC) are investigated in this work as potential tools for this objective. The MEKC technique separates substances by using fused silica capillaries with an internal diameter of 41.5 cm and a background electrolyte that includes 50 mM borate buffer with a pH of 9, 50 mM sodium lauryl sulfate (SLS), and 10\% Acetonitrile. A ZORBAX Extend- C18 column, measuring 4.6 × 250 mm and having a particle size of 5 µm, was used for separation in the HPLC technique. The mobile phase, which consisted of methanol and 50 mM phosphate buffer pH 3, was used in the gradient. With minimal values of LOD and LOQ, both techniques achieved high linearity (r > 0.9996). Both approaches were effective in identifying the examined medications’ co-administered single, binary, and ternary dose forms. As an added bonus, different combinations of co-administered dose forms in rat plasma, proving the techniques’ viability in various matrices. In line with green chemistry principles, micellar solutions are used in MEKC to increase separation efficiency and decrease organic solvent use. To minimize toxicity and waste, HPLC procedures were fine-tuned utilizing solvents that are safe for the environment. To make sure the approaches were completely sustainable, we looked at their ecological effect, safety, and practical efficiency using green, white, and blue criteria. The techniques were perfect for frequent usage in pharmaceutical analysis since they were costeffective, time-saving, and attained excellent efficiency, sensitivity, and repeatability}
}RIS (EndNote, Zotero, Mendeley)
TY - JOUR TI - Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation AU - K.SARASIRISHA AU - D CHAITANYA DIXIT AU - P.T.NAGARAJU AU - B Akhila AU - E Nagadeepthi JO - Journal of Science & Technology PY - 2025 DA - 2025/07/01/ VL - 10 IS - 07 SP - 13 EP - 28 PB - Longman Publishers SN - 2456-5660 LA - en AB - It is crucial for sustainable pharmaceutical analysis to develop two environmentally friendly analytical methods that can simultaneously determine eight cardiovascular drugs: hydrochlorothiazide (HCT), captopril (CPL), lisinopril (LSP), valsartan (VAL), atorvastatin (ATR), bisoprolol (BSL), amlodipine (AML), and carvedilol (CVL). Additionally, the nutraceutical vincamine (VIC) should be tested. Micellar Electro Kinetic Chromatography (MEKC) and High-Performance Liquid Chromatography (HPLC) are investigated in this work as potential tools for this objective. The MEKC technique separates substances by using fused silica capillaries with an internal diameter of 41.5 cm and a background electrolyte that includes 50 mM borate buffer with a pH of 9, 50 mM sodium lauryl sulfate (SLS), and 10% Acetonitrile. A ZORBAX Extend- C18 column, measuring 4.6 × 250 mm and having a particle size of 5 µm, was used for separation in the HPLC technique. The mobile phase, which consisted of methanol and 50 mM phosphate buffer pH 3, was used in the gradient. With minimal values of LOD and LOQ, both techniques achieved high linearity (r > 0.9996). Both approaches were effective in identifying the examined medications’ co-administered single, binary, and ternary dose forms. As an added bonus, different combinations of co-administered dose forms in rat plasma, proving the techniques’ viability in various matrices. In line with green chemistry principles, micellar solutions are used in MEKC to increase separation efficiency and decrease organic solvent use. To minimize toxicity and waste, HPLC procedures were fine-tuned utilizing solvents that are safe for the environment. To make sure the approaches were completely sustainable, we looked at their ecological effect, safety, and practical efficiency using green, white, and blue criteria. The techniques were perfect for frequent usage in pharmaceutical analysis since they were costeffective, time-saving, and attained excellent efficiency, sensitivity, and repeatability DO - 10.46243/jst.2025.v10.i7.pp13-28 UR - https://doi.org/10.46243/jst.2025.v10.i7.pp13-28 ER -
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From the record as registered (version 2) — the record and its history. Programs: https://registry.smartscholars.in/api.php?action=cite&doi=10.46243%2Fjst.2025.v10.i7.pp13-28 gives all four in one JSON answer.
