10.46243/jst.2025.v10.i6.pp48-67 registered
Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research
Resolves to https://www.jst.org.in/index.php/pub/article/view/1378
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2025.v10.i6.pp48-67
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 6ffc4b12d679e3c1…
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JournalArticle — an article in a journal · Digital · Visual · en
Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research (PrincipalTitle)
Published 2025-06-18
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 10 · issue 06 · pages 48–66
Agents
- DR RAVURI SRINATH (author)
- DR K CHANDRASEKHAR (author)
- DR N PADMAJA (author)
- Dr. J. GOPALA KRISHNA (author)
- PNAVYAKRISHNA (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2025.v10.i6.pp48-67
Abstract
An exciting new direction in topical administration is the use of cationic nanocapsules. To improve the photostability, user compliance, and pharmacodynamic effectiveness of tretinoin (TTN), we built on a new formulation that relies on cationic nanocapsules. The nanoprecipitation process was used to create TTN nanocapsules in order to accomplish this. A Box-Behnken design was used with the help of Design-Expert software to statistically optimize the formulation variables. The cationic acrylic polymer weight (X1), oil volume (X2), and total transdermal N-terminal thickness (X3) were the three independent variables that were examined. As for the dependent variables, we chose particle size and encapsulation efficiency percentage (EE%). With an ideal particle size of 116.3 nm and a high EE% of 83.2%, the ideal formulation displayed spherical shape under scanning electron microscopy (SEM). When compared to its methanolic solution, photostability was enhanced by TTN-loaded nanocapsules. Results from the in vitro release investigation demonstrated that, in contrast to the free drug, tretinoin was released in a sustained way. The ex vivo skin penetration investigation showed that compared to drug solution, a gel containing TTN-loaded nanocapsules caused more drug to be deposited into the epidermal area rather than the deep skin. The skin irritation test revealed that the nanoencapsulation of the drug decreased its irritancy compared to the free drug. Based on these findings, cationic nanocapsules for tretinoin topical distribution seem to be a viable option
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2025.v10.i6.pp48-67 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: DR RAVURI SRINATH author: DR K CHANDRASEKHAR author: DR N PADMAJA author: Dr. J. GOPALA KRISHNA author: PNAVYAKRISHNA publisher: Longman Publishers published: 2025-06-18 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 10 · no. 06 · pp. 48–66 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-08-27 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
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History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 159 fields set · sha256 a2423a6f6be1… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
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