Cite this DOI
10.46243/jst.2025.v10.i6.pp48-67 · Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research
APA (7th edition)
DR RAVURI SRINATH, DR K CHANDRASEKHAR, DR N PADMAJA, Dr. J. GOPALA KRISHNA, & PNAVYAKRISHNA (2025). Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research. *Journal of Science & Technology*, *10*(06), 48–66. https://doi.org/10.46243/jst.2025.v10.i6.pp48-67
⬇ text Italics are shown as *asterisks* in plain text — the journal or book title and the volume.
BibTeX
@article{drravurisrinath2025methods,
author = {DR RAVURI SRINATH and DR K CHANDRASEKHAR and DR N PADMAJA and Dr. J. GOPALA KRISHNA and PNAVYAKRISHNA},
title = {{Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research}},
journal = {Journal of Science \& Technology},
year = {2025},
month = {jun},
volume = {10},
number = {06},
pages = {48--66},
publisher = {Longman Publishers},
issn = {2456-5660},
doi = {10.46243/jst.2025.v10.i6.pp48-67},
url = {https://doi.org/10.46243/jst.2025.v10.i6.pp48-67},
language = {en},
abstract = {An exciting new direction in topical administration is the use of cationic nanocapsules. To improve the photostability, user compliance, and pharmacodynamic effectiveness of tretinoin (TTN), we built on a new formulation that relies on cationic nanocapsules. The nanoprecipitation process was used to create TTN nanocapsules in order to accomplish this. A Box-Behnken design was used with the help of Design-Expert software to statistically optimize the formulation variables. The cationic acrylic polymer weight (X1), oil volume (X2), and total transdermal N-terminal thickness (X3) were the three independent variables that were examined. As for the dependent variables, we chose particle size and encapsulation efficiency percentage (EE\%). With an ideal particle size of 116.3 nm and a high EE\% of 83.2\%, the ideal formulation displayed spherical shape under scanning electron microscopy (SEM). When compared to its methanolic solution, photostability was enhanced by TTN-loaded nanocapsules. Results from the in vitro release investigation demonstrated that, in contrast to the free drug, tretinoin was released in a sustained way. The ex vivo skin penetration investigation showed that compared to drug solution, a gel containing TTN-loaded nanocapsules caused more drug to be deposited into the epidermal area rather than the deep skin. The skin irritation test revealed that the nanoencapsulation of the drug decreased its irritancy compared to the free drug. Based on these findings, cationic nanocapsules for tretinoin topical distribution seem to be a viable option}
}RIS (EndNote, Zotero, Mendeley)
TY - JOUR TI - Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research AU - DR RAVURI SRINATH AU - DR K CHANDRASEKHAR AU - DR N PADMAJA AU - Dr. J. GOPALA KRISHNA AU - PNAVYAKRISHNA JO - Journal of Science & Technology PY - 2025 DA - 2025/06/18/ VL - 10 IS - 06 SP - 48 EP - 66 PB - Longman Publishers SN - 2456-5660 LA - en AB - An exciting new direction in topical administration is the use of cationic nanocapsules. To improve the photostability, user compliance, and pharmacodynamic effectiveness of tretinoin (TTN), we built on a new formulation that relies on cationic nanocapsules. The nanoprecipitation process was used to create TTN nanocapsules in order to accomplish this. A Box-Behnken design was used with the help of Design-Expert software to statistically optimize the formulation variables. The cationic acrylic polymer weight (X1), oil volume (X2), and total transdermal N-terminal thickness (X3) were the three independent variables that were examined. As for the dependent variables, we chose particle size and encapsulation efficiency percentage (EE%). With an ideal particle size of 116.3 nm and a high EE% of 83.2%, the ideal formulation displayed spherical shape under scanning electron microscopy (SEM). When compared to its methanolic solution, photostability was enhanced by TTN-loaded nanocapsules. Results from the in vitro release investigation demonstrated that, in contrast to the free drug, tretinoin was released in a sustained way. The ex vivo skin penetration investigation showed that compared to drug solution, a gel containing TTN-loaded nanocapsules caused more drug to be deposited into the epidermal area rather than the deep skin. The skin irritation test revealed that the nanoencapsulation of the drug decreased its irritancy compared to the free drug. Based on these findings, cationic nanocapsules for tretinoin topical distribution seem to be a viable option DO - 10.46243/jst.2025.v10.i6.pp48-67 UR - https://doi.org/10.46243/jst.2025.v10.i6.pp48-67 ER -
CSL-JSON
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} ⬇ .json What citeproc and reference managers read; the DOI system hands it out for Accept: application/vnd.citationstyles.csl+json, and so does this registry's resolver.
From the record as registered (version 2) — the record and its history. Programs: https://registry.smartscholars.in/api.php?action=cite&doi=10.46243%2Fjst.2025.v10.i6.pp48-67 gives all four in one JSON answer.
