10.46243/jst.2025.v10.i04.pp62-72 registered
Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A MultiParametric Approach
Resolves to https://www.jst.org.in/index.php/pub/article/view/1472
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2025.v10.i04.pp62-72
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 78170fad8ad4414d…
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JournalArticle — an article in a journal · Digital · Visual · en
Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A MultiParametric Approach (PrincipalTitle)
Published 2025-04-05
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 10 · issue 04 · pages 62–72
Agents
- M Kishore Babu (author)
- T Pavani (author)
- D Divyasri (author)
- P Krupa Rani (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2025.v10.i04.pp62-72
Abstract
n this study, we used the neutrophil granulocytes functional activity model to examine oxidative stress indicators, antioxidant protection, lipid peroxidation, and T1D in children. According to research, children with type 1 diabetes show heightened lipoperoxidation and antioxidant defense system activation in response to reactive oxygen species (ROS) damage, which includes bidirectional alterations in non-enzymatic pathways. The development of tolerance to oxidative stress in children with compensated type 1 diabetes is indicated by the coordinated synthesis of reactive oxygen species and oxygen-dependent blood cell metabolism. In children with decompensated type 1 diabetes, it is indicated that the third stage of oxidative stress, which involves the depletion of insulin-producing β-cells, begins with a decrease in reactive oxygen species production, a decrease in the activation of the phagocyte oxygen-dependent metabolism, and incomplete phagocytosis mechanisms. The severity of metabolic problems in children with type 1 diabetes is influenced by the level of the antioxidant defense system's "respiratory explosion" of neutrophilic granulocytes.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2025.v10.i04.pp62-72 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A MultiParametric Approach (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: M Kishore Babu author: T Pavani author: D Divyasri author: P Krupa Rani publisher: Longman Publishers published: 2025-04-05 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 10 · no. 04 · pp. 62–72 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-08-27 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
complete Every System Metadata element is here, with the basic metadata a journal article needs.
The System Metadata Declaration (JSON) · the Kernel Metadata Declaration (XML) · what each sub-type needs
History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 175 fields set · sha256 d01111d69685… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
Machine-readable: the history as JSON, with the full record after each change.
