10.46243/jst.2021.v6.i3.pp75-79 registered
A Review on Formulation and Evaluation of Nifedipine Sublingual Tablets
Resolves to https://www.jst.org.in/index.php/pub/article/view/819
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2021.v6.i3.pp75-79
Registered 29 Sep 2026 via crossref · record version 2 · last change 30 Sep 2026, 12:00 AM · record sha256 26ce402edc28c321…
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What the DOI identifies
JournalArticle — an article in a journal · Digital · Visual · en
A Review on Formulation and Evaluation of Nifedipine Sublingual Tablets (PrincipalTitle)
Published 2021-05-27
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 06 · issue 03 · pages 75–79
Agents
- Amit A. Khachane (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2021.v6.i3.pp75-79
Abstract
The aim of this study was to evaluate the effect of increasing nifedipine load on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension. Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of 43-77%. Sublingual dosage form bypasses the metabolism of the nifedipine in liver and offers a fast relieve from anginal pain and hypertension. An attempt has been made to prepare fast dissolving tablets of nifedipine using super distintegrants like Cross Carmellose Sodium, Sodium Starch Glycolate, CrosPovidone. Three different groups of formulations (A, R, and V) with variation in tablet excipients were prepared by direct compression method.Tablet weight variation, hardness, friability, drug content, disintegration time and dissolution time were evaluated for each formulation and found satisfactory. The studied sublingual tablet group V shows a lesser T50% compared to commercial oral tablet. The Group V also indicates the fast dissolution and disintegration rate of the optimized nifedipine sublingual tablet, which is prerequisite for rapid management of anginal and hypertension diseases.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2021.v6.i3.pp75-79 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | A Review on Formulation and Evaluation of Nifedipine Sublingual Tablets (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: Amit A. Khachane publisher: Longman Publishers published: 2021-05-27 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 06 · no. 03 · pp. 75–79 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-09-12 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
complete Every System Metadata element is here, with the basic metadata a journal article needs.
The System Metadata Declaration (JSON) · the Kernel Metadata Declaration (XML) · what each sub-type needs
History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 84 fields set · sha256 4b13a63d5a33… |
| 2 | 30 Sep 2026, 12:00 AM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
Machine-readable: the history as JSON, with the full record after each change.
