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                    "value": "The aim of this study was to evaluate the effect of increasing nifedipine load on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension. Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of 43-77%. Sublingual dosage form bypasses the metabolism of the nifedipine in liver and offers a fast relieve from anginal pain and hypertension. An attempt has been made to prepare fast dissolving tablets of nifedipine using super distintegrants like Cross Carmellose Sodium, Sodium Starch Glycolate, CrosPovidone. Three different groups of formulations (A, R, and V) with variation in tablet excipients were prepared by direct compression method.Tablet weight variation, hardness, friability, drug content, disintegration time and dissolution time were evaluated for each formulation and found satisfactory. The studied sublingual tablet group V shows a lesser T50% compared to commercial oral tablet. The Group V also indicates the fast dissolution and disintegration rate of the optimized nifedipine sublingual tablet, which is prerequisite for rapid management of anginal and hypertension diseases.",
                    "lang": "en"
                },
                "license": {
                    "url": "https://creativecommons.org/licenses/by/4.0/",
                    "start": "2021-05-27",
                    "applies_to": "vor"
                },
                "references": [
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