10.46243/jst.2020.v5.i4.pp173-187 registered
Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles
Resolves to https://www.jst.org.in/index.php/pub/article/view/568
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2020.v5.i4.pp173-187
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 5d1ad3d55112603f…
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JournalArticle — an article in a journal · Digital · Visual · en
Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles (PrincipalTitle)
Published 2020-07-30
Part of Journal of Science & Technology · ISSN 2456-5660 · issue Volume 5 · pages 173–187
Agents
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2020.v5.i4.pp173-187
Abstract
Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination
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Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2020.v5.i4.pp173-187 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | publisher: Longman Publishers published: 2020-07-30 part of: Journal of Science & Technology · ISSN 2456-5660 · no. Volume 5 · pp. 173–187 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2020-07-30 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
complete Every System Metadata element is here, with the basic metadata a journal article needs.
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History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 120 fields set · sha256 a5b36f2834d2… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | abstract.value: container.titles.0.value: titles.0.value: |
Machine-readable: the history as JSON, with the full record after each change.
