{ "ok": true, "doi": "10.46243/jst.2020.v5.i4.pp173-187", "events": [ { "seq": 1, "kind": "register", "at": "2026-09-29 22:00:22", "by": "Administrator (admin)", "by_kind": "user", "note": "registered at Crossref; record read from api.crossref.org", "changes": [ { "path": "abstract.lang", "from": null, "to": "en" }, { "path": "abstract.value", "from": null, "to": "Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination" }, { "path": "agents.0.name.org", "from": null, "to": "Longman Publishers" }, { "path": "agents.0.role", "from": null, "to": "publisher" }, { "path": "characters.0", "from": null, "to": "Language" }, { "path": "container.identifiers.0.medium", "from": null, "to": "electronic" }, { "path": "container.identifiers.0.type", "from": null, "to": "ISSN" }, { "path": "container.identifiers.0.value", "from": null, "to": "2456-5660" }, { "path": "container.issue", "from": null, "to": "Volume 5" }, { "path": "container.pages.first", "from": null, "to": "173" }, { "path": "container.pages.last", "from": null, "to": "187" }, { "path": "container.titles.0.type", "from": null, "to": "PrincipalTitle" }, { "path": "container.titles.0.value", "from": null, "to": "Journal of Science & Technology" }, { "path": "container.type", "from": null, "to": "Journal" }, { "path": "dates.date_type", "from": null, "to": "PublicationDate" }, { "path": "dates.online", "from": null, "to": "2020-07-30" }, { "path": "dates.published", "from": null, "to": "2020-07-30" }, { "path": "doi", "from": null, "to": "10.46243/jst.2020.v5.i4.pp173-187" }, { "path": "format", "from": null, "to": "smartscholars-doi-metadata/1.0" }, { "path": "identifiers.0.type", "from": null, "to": "DOI" }, { "path": "identifiers.0.value", "from": null, "to": "10.46243/jst.2020.v5.i4.pp173-187" }, { "path": "language", "from": null, "to": "en" }, { "path": "license.applies_to", "from": null, "to": "vor" }, { "path": "license.start", "from": null, "to": "2020-07-30" }, { "path": "license.url", "from": null, "to": "https://creativecommons.org/licenses/by/4.0" }, { "path": "links.0.primary", "from": null, "to": true }, { "path": "links.0.return_type", "from": null, "to": "text/html" }, { "path": "links.0.url", "from": null, "to": "https://www.jst.org.in/index.php/pub/article/view/568" }, { "path": "links.1.purpose", "from": null, "to": "text-mining" }, { "path": "links.1.return_type", "from": null, "to": "application/pdf" }, { "path": "links.1.url", "from": null, "to": "https://www.jst.org.in/index.php/pub/article/download/568/508" }, { "path": "links.2.purpose", "from": null, "to": "text-mining" }, { "path": "links.2.return_type", "from": null, "to": "application/xml" }, { "path": "links.2.url", "from": null, "to": "https://www.jst.org.in/index.php/pub/article/download/568/3077" }, { "path": "modes.0", "from": null, "to": "Visual" }, { "path": "record.issue_number", "from": null, "to": 1 }, { "path": "record.registered", "from": null, "to": "2020-07-30" }, { "path": "record.registrant", "from": null, "to": "Longman Publishers" }, { "path": "record.source", "from": null, "to": "crossref-api" }, { "path": "record.source_agency", "from": null, "to": "Crossref (member 25296)" }, { "path": "record.updated", "from": null, "to": "2026-09-17" }, { "path": "references.0.key", "from": null, "to": "ref1" }, { "path": "references.0.unstructured", "from": null, "to": "Langer R. Drug delivery and targeting. Nature. 1998; 392(6679): 5–10" }, { "path": "references.1.doi", "from": null, "to": "10.1016/j.addr.2012.09.019" }, { "path": "references.1.key", "from": null, "to": "ref2" }, { "path": "references.1.unstructured", "from": null, "to": "Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.Adv Drug Deliv Rev. 2001; 46: 3-26" }, { "path": "references.10.doi", "from": null, "to": "10.1016/j.ejpb.2007.03.022" }, { "path": "references.10.key", "from": null, "to": "ref11" }, { "path": "references.10.unstructured", "from": null, "to": "Chiappetta DA, Sosnik A. Poly (ethylene oxide)-poly (propylene oxide) block copolymer micelles as drug delivery agents: improved hydro solubility, stability and bioavailability of drugs. Eur. J. Pharm. Biopharm. 2007; 66(3): 303" }, { "path": "references.11.doi", "from": null, "to": "10.1016/j.jconrel.2003.10.018" }, { "path": "references.11.key", "from": null, "to": "ref12" }, { "path": "references.11.unstructured", "from": null, "to": "Oh KT, Bronich TK, Kabanov AV. Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers. J. Control. Release. 2004; 94(2): 411–22" }, { "path": "references.12.doi", "from": null, "to": "10.1016/j.jcis.2003.11.034" }, { "path": "references.12.key", "from": null, "to": "ref13" }, { "path": "references.12.unstructured", "from": null, "to": "Mansur CRE, Barboza SP, González G, Lucas EF. PLURONIC x TETRONIC polyols: study of their properties and performance in the destabilization of emulsions formed in the petroleum industry. J. Colloid Interface Sci. 2004; 271: 232–40" }, { "path": "references.13.doi", "from": null, "to": "10.1016/s0927-7765(99)00058-2" }, { "path": "references.13.key", "from": null, "to": "ref14" }, { "path": "references.13.unstructured", "from": null, "to": "Allen CD, Maysinger A. Eisenberg, Nano-engineering block copolymer aggregates for drug delivery, Coll. Surf. B Biointerf.1999; 16: 1–35" }, { "path": "references.14.key", "from": null, "to": "ref15" }, { "path": "references.14.unstructured", "from": null, "to": "Seizures and Epilepsy: Hope Through Research. National Institute of Neurological disorders and stroke.2010 July26.Availaible from: URL: http:// www.ninds.nih.gov/disorders/epilepsy/detailepilepsy. htm (Assessed on 30th July 2010)" }, { "path": "references.15.doi", "from": null, "to": "10.1016/j.jconrel.2004.09.021" }, { "path": "references.15.key", "from": null, "to": "ref16" }, { "path": "references.15.unstructured", "from": null, "to": "Rxlist. Availaible From: URL: www.Rxlist.com. (Assessed on 30th July 2010) 17.Gao ZG, Fain HD, Rapoport N. Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultra sound. J. Controlled Release. 2005; 102(1): 203" }, { "path": "references.16.doi", "from": null, "to": "10.1007/s11743-002-0226-9" }, { "path": "references.16.key", "from": null, "to": "ref17" }, { "path": "references.16.unstructured", "from": null, "to": "Sharma, Rakesh, Bahadur P. Effect of different additives on the cloud point of a polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymer in aqueous solution. Journal of Surfactants and Detergents. July 2002; 5(3): 263-8. 19.Zageer Ahmad, Polymeric micelle as drug delivery vehicle from www.rsc.org March 2014( 4)-17029" }, { "path": "references.17.key", "from": null, "to": "ref18" }, { "path": "references.17.unstructured", "from": null, "to": "FrazanehSotoudegan, Nimodipine loaded pluronic block copolymer micelle by Iranian Journal of Pharmaceutical research, Feb 2016 15(4) 641-661" }, { "path": "references.18.doi", "from": null, "to": "10.1194/jlr.m600211-jlr200" }, { "path": "references.18.key", "from": null, "to": "ref19" }, { "path": "references.18.unstructured", "from": null, "to": "SumbulFatma, ReuvenYakubov, Kamran Anwar M, MahmoodHussain. Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion. Journal of Lipid Research. 2006; 47(11): 2422-32" }, { "path": "references.19.doi", "from": null, "to": "10.1016/0927-7757(94)03028-x" }, { "path": "references.19.key", "from": null, "to": "ref20" }, { "path": "references.19.unstructured", "from": null, "to": "Alexandridis P, Hatton TA. Poly (ethylene oxide)-poly-(propylene oxide)poly (ethylene oxide) block copolymer surfactant in aqueous solution and at interfaces: thermodynamics, structure, dynamics and modeling. Colloids surface A: Physicochem. Eng. Aspects. 1996; 96(1): 1-" }, { "path": "references.2.doi", "from": null, "to": "10.1021/jm0108754" }, { "path": "references.2.key", "from": null, "to": "ref3" }, { "path": "references.2.unstructured", "from": null, "to": "Fernandez AM, Van Derpoorten K, Dasnois L. N-Succinyl-(beta-alanyl-Lleucyl-L-alanyl-L-leucyl) doxorubicin: an extra cellularlytumoractivated prodrug devoid of intravenous acute toxicity. J Med Chem.2001; 44: 3750-3" }, { "path": "references.20.key", "from": null, "to": "ref21" }, { "path": "references.20.unstructured", "from": null, "to": "LAMOTRIGINE-Lamotrigine tablet, Roxane Laboratories, Inc. Available from: URL. http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo. cfm?archiveid=20548" }, { "path": "references.21.doi", "from": null, "to": "10.1021/la902795h" }, { "path": "references.21.key", "from": null, "to": "ref22" }, { "path": "references.21.unstructured", "from": null, "to": "Ronald Soong, Mu-Ping Nieh, Eric Nicholson, John Katsaras, Peter M, Macdonald. Bicellar mixtures containing pluronic F68: morphology and lateral diffusion from combined SANS and PFG NMR studies. Langmuir. 2010; 26(4): 2630–8" }, { "path": "references.22.doi", "from": null, "to": "10.1016/j.colsurfa.2010.04.025" }, { "path": "references.22.key", "from": null, "to": "ref23" }, { "path": "references.22.unstructured", "from": null, "to": "Kadam Y, Bharatiya B, Hassan PA, Verma G, Aswal VK, Bahadur P. Effect of an amphiphilic diol (Surfynol®) on the micellar characteristics of PEO–PPO–PEO block copolymers in aqueous solutions. Colloids Surf. A: Physico chem. Eng. Aspects. 2010; 363(1): 110" }, { "path": "references.23.doi", "from": null, "to": "10.1615/critrevtherdrugcarriersyst.v19.i1.10" }, { "path": "references.23.key", "from": null, "to": "ref24" }, { "path": "references.23.unstructured", "from": null, "to": "Kabanov AV, Alakov VY. Pluronic block copolymers in drug delivery: from micellar nano containers to biological response modifiers, Crit. Rev. Ther. Drug Carrier Syst. 2002; 19(1): 1–73" }, { "path": "references.24.doi", "from": null, "to": "10.1194/jlr.m600211-jlr200" }, { "path": "references.24.key", "from": null, "to": "ref25" }, { "path": "references.24.unstructured", "from": null, "to": "SumbulFatma, ReuvenYakubov, Kamran Anwar M, MahmoodHussain. Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion. Journal of Lipid Research. 2006; 47(11): 2422-32" }, { "path": "references.25.doi", "from": null, "to": "10.5530/ijper.48.4s.8" }, { "path": "references.25.key", "from": null, "to": "ref26" }, { "path": "references.25.unstructured", "from": null, "to": "Shilpa micelle as Praveen Chaudhari, Study of block copolymer micelles as vehicle for hydrophobic drug Lamotrigine by Pharmaceutical Research Dec 2014" }, { "path": "references.3.doi", "from": null, "to": "10.2174/138945006777435245" }, { "path": "references.3.key", "from": null, "to": "ref4" }, { "path": "references.3.unstructured", "from": null, "to": "Groneberg DA, Giersig M, Welte T. Nanoparticle-based diagnosis and therapy. Curr Drug targets. 2006; 7: 643-8" }, { "path": "references.4.doi", "from": null, "to": "10.1016/j.addr.2006.09.011" }, { "path": "references.4.key", "from": null, "to": "ref5" }, { "path": "references.4.unstructured", "from": null, "to": "Farokhzad OC, Langer R. Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv Drug Deliv Rev. 2006; 58(14): 1456- 9" }, { "path": "references.5.doi", "from": null, "to": "10.1517/17425247.3.1.139" }, { "path": "references.5.key", "from": null, "to": "ref6" }, { "path": "references.5.unstructured", "from": null, "to": "Aliabadi HM, Lavasanifar A. Polymeric micelles for drug delivery. Expert Opin.Drug Deliv. 2006; 12(36): 139-62" }, { "path": "references.6.doi", "from": null, "to": "10.1016/j.jconrel.2009.11.012" }, { "path": "references.6.key", "from": null, "to": "ref7" }, { "path": "references.6.unstructured", "from": null, "to": "Gaucher G, Marchessault RH, Leroux JC. Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes. J. Control. Release. 2010; 143(1): 2-12" }, { "path": "references.7.doi", "from": null, "to": "10.1016/j.cis.2006.05.016" }, { "path": "references.7.key", "from": null, "to": "ref8" }, { "path": "references.7.unstructured", "from": null, "to": "Nakasima K, Bahadur P. Aggregation of water-soluble block copolymers in aqueous solutions: recent trends. Adv. Colloid Interface Sci. 2006; 123: 75" }, { "path": "references.8.key", "from": null, "to": "ref9" }, { "path": "references.8.unstructured", "from": null, "to": "Riess G, Hurtrez G, Bahadur P. Block Copolymers, Encyclopaedia of Polymer Science and Engineering, 2nd ed., Wiley, New York; 1985" }, { "path": "references.9.doi", "from": null, "to": "10.1016/j.ejpb.2006.06.011" }, { "path": "references.9.key", "from": null, "to": "ref10" }, { "path": "references.9.unstructured", "from": null, "to": "Sezgin Z, Yuksel N, Baykara T. Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs. Eur. J. Pharm. Biopharm. 2006; 64(3): 261" }, { "path": "referent", "from": null, "to": "Creation" }, { "path": "structural_type", "from": null, "to": "Digital" }, { "path": "titles.0.lang", "from": null, "to": "en" }, { "path": "titles.0.type", "from": null, "to": "PrincipalTitle" }, { "path": "titles.0.value", "from": null, "to": "Formulation, Development and Evaluation of Lopinavir Loaded\nPolymeric Micelles" }, { "path": "type", "from": null, "to": "JournalArticle" } ], "record_after": { "format": "smartscholars-doi-metadata/1.0", "doi": "10.46243/jst.2020.v5.i4.pp173-187", "referent": "Creation", "type": "JournalArticle", "structural_type": "Digital", "modes": [ "Visual" ], "characters": [ "Language" ], "titles": [ { "value": "Formulation, Development and Evaluation of Lopinavir Loaded\nPolymeric Micelles", "type": "PrincipalTitle", "lang": "en" } ], "identifiers": [ { "type": "DOI", "value": "10.46243/jst.2020.v5.i4.pp173-187" } ], "agents": [ { "role": "publisher", "name": { "org": "Longman Publishers" } } ], "dates": { "published": "2020-07-30", "date_type": "PublicationDate", "online": "2020-07-30" }, "language": "en", "container": { "type": "Journal", "titles": [ { "value": "Journal of Science & Technology", "type": "PrincipalTitle" } ], "identifiers": [ { "type": "ISSN", "value": "2456-5660", "medium": "electronic" } ], "issue": "Volume 5", "pages": { "first": "173", "last": "187" } }, "links": [ { "url": "https://www.jst.org.in/index.php/pub/article/view/568", "return_type": "text/html", "primary": true }, { "url": "https://www.jst.org.in/index.php/pub/article/download/568/508", "purpose": "text-mining", "return_type": "application/pdf" }, { "url": "https://www.jst.org.in/index.php/pub/article/download/568/3077", "purpose": "text-mining", "return_type": "application/xml" } ], "abstract": { "value": "Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0", "start": "2020-07-30", "applies_to": "vor" }, "references": [ { "key": "ref1", "unstructured": "Langer R. Drug delivery and targeting. Nature. 1998; 392(6679): 5–10" }, { "key": "ref2", "doi": "10.1016/j.addr.2012.09.019", "unstructured": "Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.Adv Drug Deliv Rev. 2001; 46: 3-26" }, { "key": "ref3", "doi": "10.1021/jm0108754", "unstructured": "Fernandez AM, Van Derpoorten K, Dasnois L. N-Succinyl-(beta-alanyl-Lleucyl-L-alanyl-L-leucyl) doxorubicin: an extra cellularlytumoractivated prodrug devoid of intravenous acute toxicity. J Med Chem.2001; 44: 3750-3" }, { "key": "ref4", "doi": "10.2174/138945006777435245", "unstructured": "Groneberg DA, Giersig M, Welte T. Nanoparticle-based diagnosis and therapy. Curr Drug targets. 2006; 7: 643-8" }, { "key": "ref5", "doi": "10.1016/j.addr.2006.09.011", "unstructured": "Farokhzad OC, Langer R. Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv Drug Deliv Rev. 2006; 58(14): 1456- 9" }, { "key": "ref6", "doi": "10.1517/17425247.3.1.139", "unstructured": "Aliabadi HM, Lavasanifar A. Polymeric micelles for drug delivery. Expert Opin.Drug Deliv. 2006; 12(36): 139-62" }, { "key": "ref7", "doi": "10.1016/j.jconrel.2009.11.012", "unstructured": "Gaucher G, Marchessault RH, Leroux JC. Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes. J. Control. Release. 2010; 143(1): 2-12" }, { "key": "ref8", "doi": "10.1016/j.cis.2006.05.016", "unstructured": "Nakasima K, Bahadur P. Aggregation of water-soluble block copolymers in aqueous solutions: recent trends. Adv. Colloid Interface Sci. 2006; 123: 75" }, { "key": "ref9", "unstructured": "Riess G, Hurtrez G, Bahadur P. Block Copolymers, Encyclopaedia of Polymer Science and Engineering, 2nd ed., Wiley, New York; 1985" }, { "key": "ref10", "doi": "10.1016/j.ejpb.2006.06.011", "unstructured": "Sezgin Z, Yuksel N, Baykara T. Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs. Eur. J. Pharm. Biopharm. 2006; 64(3): 261" }, { "key": "ref11", "doi": "10.1016/j.ejpb.2007.03.022", "unstructured": "Chiappetta DA, Sosnik A. Poly (ethylene oxide)-poly (propylene oxide) block copolymer micelles as drug delivery agents: improved hydro solubility, stability and bioavailability of drugs. Eur. J. Pharm. Biopharm. 2007; 66(3): 303" }, { "key": "ref12", "doi": "10.1016/j.jconrel.2003.10.018", "unstructured": "Oh KT, Bronich TK, Kabanov AV. Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers. J. Control. Release. 2004; 94(2): 411–22" }, { "key": "ref13", "doi": "10.1016/j.jcis.2003.11.034", "unstructured": "Mansur CRE, Barboza SP, González G, Lucas EF. PLURONIC x TETRONIC polyols: study of their properties and performance in the destabilization of emulsions formed in the petroleum industry. J. Colloid Interface Sci. 2004; 271: 232–40" }, { "key": "ref14", "doi": "10.1016/s0927-7765(99)00058-2", "unstructured": "Allen CD, Maysinger A. Eisenberg, Nano-engineering block copolymer aggregates for drug delivery, Coll. Surf. B Biointerf.1999; 16: 1–35" }, { "key": "ref15", "unstructured": "Seizures and Epilepsy: Hope Through Research. National Institute of Neurological disorders and stroke.2010 July26.Availaible from: URL: http:// www.ninds.nih.gov/disorders/epilepsy/detailepilepsy. htm (Assessed on 30th July 2010)" }, { "key": "ref16", "doi": "10.1016/j.jconrel.2004.09.021", "unstructured": "Rxlist. Availaible From: URL: www.Rxlist.com. (Assessed on 30th July 2010) 17.Gao ZG, Fain HD, Rapoport N. Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultra sound. J. Controlled Release. 2005; 102(1): 203" }, { "key": "ref17", "doi": "10.1007/s11743-002-0226-9", "unstructured": "Sharma, Rakesh, Bahadur P. Effect of different additives on the cloud point of a polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymer in aqueous solution. Journal of Surfactants and Detergents. July 2002; 5(3): 263-8. 19.Zageer Ahmad, Polymeric micelle as drug delivery vehicle from www.rsc.org March 2014( 4)-17029" }, { "key": "ref18", "unstructured": "FrazanehSotoudegan, Nimodipine loaded pluronic block copolymer micelle by Iranian Journal of Pharmaceutical research, Feb 2016 15(4) 641-661" }, { "key": "ref19", "doi": "10.1194/jlr.m600211-jlr200", "unstructured": "SumbulFatma, ReuvenYakubov, Kamran Anwar M, MahmoodHussain. Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion. Journal of Lipid Research. 2006; 47(11): 2422-32" }, { "key": "ref20", "doi": "10.1016/0927-7757(94)03028-x", "unstructured": "Alexandridis P, Hatton TA. Poly (ethylene oxide)-poly-(propylene oxide)poly (ethylene oxide) block copolymer surfactant in aqueous solution and at interfaces: thermodynamics, structure, dynamics and modeling. Colloids surface A: Physicochem. Eng. Aspects. 1996; 96(1): 1-" }, { "key": "ref21", "unstructured": "LAMOTRIGINE-Lamotrigine tablet, Roxane Laboratories, Inc. Available from: URL. http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo. cfm?archiveid=20548" }, { "key": "ref22", "doi": "10.1021/la902795h", "unstructured": "Ronald Soong, Mu-Ping Nieh, Eric Nicholson, John Katsaras, Peter M, Macdonald. Bicellar mixtures containing pluronic F68: morphology and lateral diffusion from combined SANS and PFG NMR studies. Langmuir. 2010; 26(4): 2630–8" }, { "key": "ref23", "doi": "10.1016/j.colsurfa.2010.04.025", "unstructured": "Kadam Y, Bharatiya B, Hassan PA, Verma G, Aswal VK, Bahadur P. Effect of an amphiphilic diol (Surfynol®) on the micellar characteristics of PEO–PPO–PEO block copolymers in aqueous solutions. Colloids Surf. A: Physico chem. Eng. Aspects. 2010; 363(1): 110" }, { "key": "ref24", "doi": "10.1615/critrevtherdrugcarriersyst.v19.i1.10", "unstructured": "Kabanov AV, Alakov VY. Pluronic block copolymers in drug delivery: from micellar nano containers to biological response modifiers, Crit. Rev. Ther. Drug Carrier Syst. 2002; 19(1): 1–73" }, { "key": "ref25", "doi": "10.1194/jlr.m600211-jlr200", "unstructured": "SumbulFatma, ReuvenYakubov, Kamran Anwar M, MahmoodHussain. Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion. Journal of Lipid Research. 2006; 47(11): 2422-32" }, { "key": "ref26", "doi": "10.5530/ijper.48.4s.8", "unstructured": "Shilpa micelle as Praveen Chaudhari, Study of block copolymer micelles as vehicle for hydrophobic drug Lamotrigine by Pharmaceutical Research Dec 2014" } ], "record": { "registrant": "Longman Publishers", "registered": "2020-07-30", "updated": "2026-09-17", "issue_number": 1, "source": "crossref-api", "source_agency": "Crossref (member 25296)" } }, "url_after": "https://www.jst.org.in/index.php/pub/article/view/568", "sha256_before": null, "sha256_after": "a5b36f2834d2a1f7e2c05ba628e75db8216bc7659a911b0d12a7ad297270d4c9" }, { "seq": 2, "kind": "update", "at": "2026-09-29 23:59:41", "by": "Administrator (admin)", "by_kind": "user", "note": "record re-read from api.crossref.org", "changes": [ { "path": "abstract.value", "from": "Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination", "to": "Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination" }, { "path": "container.titles.0.value", "from": "Journal of Science & Technology", "to": "Journal of Science & Technology" }, { "path": "titles.0.value", "from": "Formulation, Development and Evaluation of Lopinavir Loaded\nPolymeric Micelles", "to": "Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles" } ], "record_after": { "format": "smartscholars-doi-metadata/1.0", "doi": "10.46243/jst.2020.v5.i4.pp173-187", "referent": "Creation", "type": "JournalArticle", "structural_type": "Digital", "modes": [ "Visual" ], "characters": [ "Language" ], "titles": [ { "value": "Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles", "type": "PrincipalTitle", "lang": "en" } ], "identifiers": [ { "type": "DOI", "value": "10.46243/jst.2020.v5.i4.pp173-187" } ], "agents": [ { "role": "publisher", "name": { "org": "Longman Publishers" } } ], "dates": { "published": "2020-07-30", "date_type": "PublicationDate", "online": "2020-07-30" }, "language": "en", "container": { "type": "Journal", "titles": [ { "value": "Journal of Science & Technology", "type": "PrincipalTitle" } ], "identifiers": [ { "type": "ISSN", "value": "2456-5660", "medium": "electronic" } ], "issue": "Volume 5", "pages": { "first": "173", "last": "187" } }, "links": [ { "url": "https://www.jst.org.in/index.php/pub/article/view/568", "return_type": "text/html", "primary": true }, { "url": "https://www.jst.org.in/index.php/pub/article/download/568/508", "purpose": "text-mining", "return_type": "application/pdf" }, { "url": "https://www.jst.org.in/index.php/pub/article/download/568/3077", "purpose": "text-mining", "return_type": "application/xml" } ], "abstract": { "value": "Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0", "start": "2020-07-30", "applies_to": "vor" }, "references": [ { "key": "ref1", "unstructured": "Langer R. Drug delivery and targeting. Nature. 1998; 392(6679): 5–10" }, { "key": "ref2", "doi": "10.1016/j.addr.2012.09.019", "unstructured": "Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.Adv Drug Deliv Rev. 2001; 46: 3-26" }, { "key": "ref3", "doi": "10.1021/jm0108754", "unstructured": "Fernandez AM, Van Derpoorten K, Dasnois L. N-Succinyl-(beta-alanyl-Lleucyl-L-alanyl-L-leucyl) doxorubicin: an extra cellularlytumoractivated prodrug devoid of intravenous acute toxicity. J Med Chem.2001; 44: 3750-3" }, { "key": "ref4", "doi": "10.2174/138945006777435245", "unstructured": "Groneberg DA, Giersig M, Welte T. Nanoparticle-based diagnosis and therapy. Curr Drug targets. 2006; 7: 643-8" }, { "key": "ref5", "doi": "10.1016/j.addr.2006.09.011", "unstructured": "Farokhzad OC, Langer R. Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv Drug Deliv Rev. 2006; 58(14): 1456- 9" }, { "key": "ref6", "doi": "10.1517/17425247.3.1.139", "unstructured": "Aliabadi HM, Lavasanifar A. Polymeric micelles for drug delivery. Expert Opin.Drug Deliv. 2006; 12(36): 139-62" }, { "key": "ref7", "doi": "10.1016/j.jconrel.2009.11.012", "unstructured": "Gaucher G, Marchessault RH, Leroux JC. Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes. J. Control. Release. 2010; 143(1): 2-12" }, { "key": "ref8", "doi": "10.1016/j.cis.2006.05.016", "unstructured": "Nakasima K, Bahadur P. Aggregation of water-soluble block copolymers in aqueous solutions: recent trends. Adv. Colloid Interface Sci. 2006; 123: 75" }, { "key": "ref9", "unstructured": "Riess G, Hurtrez G, Bahadur P. Block Copolymers, Encyclopaedia of Polymer Science and Engineering, 2nd ed., Wiley, New York; 1985" }, { "key": "ref10", "doi": "10.1016/j.ejpb.2006.06.011", "unstructured": "Sezgin Z, Yuksel N, Baykara T. Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs. Eur. J. Pharm. Biopharm. 2006; 64(3): 261" }, { "key": "ref11", "doi": "10.1016/j.ejpb.2007.03.022", "unstructured": "Chiappetta DA, Sosnik A. Poly (ethylene oxide)-poly (propylene oxide) block copolymer micelles as drug delivery agents: improved hydro solubility, stability and bioavailability of drugs. Eur. J. Pharm. Biopharm. 2007; 66(3): 303" }, { "key": "ref12", "doi": "10.1016/j.jconrel.2003.10.018", "unstructured": "Oh KT, Bronich TK, Kabanov AV. Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers. J. Control. Release. 2004; 94(2): 411–22" }, { "key": "ref13", "doi": "10.1016/j.jcis.2003.11.034", "unstructured": "Mansur CRE, Barboza SP, González G, Lucas EF. PLURONIC x TETRONIC polyols: study of their properties and performance in the destabilization of emulsions formed in the petroleum industry. J. Colloid Interface Sci. 2004; 271: 232–40" }, { "key": "ref14", "doi": "10.1016/s0927-7765(99)00058-2", "unstructured": "Allen CD, Maysinger A. Eisenberg, Nano-engineering block copolymer aggregates for drug delivery, Coll. Surf. B Biointerf.1999; 16: 1–35" }, { "key": "ref15", "unstructured": "Seizures and Epilepsy: Hope Through Research. National Institute of Neurological disorders and stroke.2010 July26.Availaible from: URL: http:// www.ninds.nih.gov/disorders/epilepsy/detailepilepsy. htm (Assessed on 30th July 2010)" }, { "key": "ref16", "doi": "10.1016/j.jconrel.2004.09.021", "unstructured": "Rxlist. Availaible From: URL: www.Rxlist.com. (Assessed on 30th July 2010) 17.Gao ZG, Fain HD, Rapoport N. Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultra sound. J. Controlled Release. 2005; 102(1): 203" }, { "key": "ref17", "doi": "10.1007/s11743-002-0226-9", "unstructured": "Sharma, Rakesh, Bahadur P. Effect of different additives on the cloud point of a polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymer in aqueous solution. Journal of Surfactants and Detergents. July 2002; 5(3): 263-8. 19.Zageer Ahmad, Polymeric micelle as drug delivery vehicle from www.rsc.org March 2014( 4)-17029" }, { "key": "ref18", "unstructured": "FrazanehSotoudegan, Nimodipine loaded pluronic block copolymer micelle by Iranian Journal of Pharmaceutical research, Feb 2016 15(4) 641-661" }, { "key": "ref19", "doi": "10.1194/jlr.m600211-jlr200", "unstructured": "SumbulFatma, ReuvenYakubov, Kamran Anwar M, MahmoodHussain. Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion. Journal of Lipid Research. 2006; 47(11): 2422-32" }, { "key": "ref20", "doi": "10.1016/0927-7757(94)03028-x", "unstructured": "Alexandridis P, Hatton TA. Poly (ethylene oxide)-poly-(propylene oxide)poly (ethylene oxide) block copolymer surfactant in aqueous solution and at interfaces: thermodynamics, structure, dynamics and modeling. Colloids surface A: Physicochem. Eng. Aspects. 1996; 96(1): 1-" }, { "key": "ref21", "unstructured": "LAMOTRIGINE-Lamotrigine tablet, Roxane Laboratories, Inc. Available from: URL. http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo. cfm?archiveid=20548" }, { "key": "ref22", "doi": "10.1021/la902795h", "unstructured": "Ronald Soong, Mu-Ping Nieh, Eric Nicholson, John Katsaras, Peter M, Macdonald. Bicellar mixtures containing pluronic F68: morphology and lateral diffusion from combined SANS and PFG NMR studies. Langmuir. 2010; 26(4): 2630–8" }, { "key": "ref23", "doi": "10.1016/j.colsurfa.2010.04.025", "unstructured": "Kadam Y, Bharatiya B, Hassan PA, Verma G, Aswal VK, Bahadur P. Effect of an amphiphilic diol (Surfynol®) on the micellar characteristics of PEO–PPO–PEO block copolymers in aqueous solutions. Colloids Surf. A: Physico chem. Eng. Aspects. 2010; 363(1): 110" }, { "key": "ref24", "doi": "10.1615/critrevtherdrugcarriersyst.v19.i1.10", "unstructured": "Kabanov AV, Alakov VY. Pluronic block copolymers in drug delivery: from micellar nano containers to biological response modifiers, Crit. Rev. Ther. Drug Carrier Syst. 2002; 19(1): 1–73" }, { "key": "ref25", "doi": "10.1194/jlr.m600211-jlr200", "unstructured": "SumbulFatma, ReuvenYakubov, Kamran Anwar M, MahmoodHussain. Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion. Journal of Lipid Research. 2006; 47(11): 2422-32" }, { "key": "ref26", "doi": "10.5530/ijper.48.4s.8", "unstructured": "Shilpa micelle as Praveen Chaudhari, Study of block copolymer micelles as vehicle for hydrophobic drug Lamotrigine by Pharmaceutical Research Dec 2014" } ], "record": { "registrant": "Longman Publishers", "registered": "2020-07-30", "updated": "2026-09-17", "issue_number": 1, "source": "crossref-api", "source_agency": "Crossref (member 25296)" } }, "url_after": "https://www.jst.org.in/index.php/pub/article/view/568", "sha256_before": "a5b36f2834d2a1f7e2c05ba628e75db8216bc7659a911b0d12a7ad297270d4c9", "sha256_after": "5d1ad3d55112603fed27c8b0c042e067bb2d7d8c40e5d277a70634b96bdc0b2b" } ] }