Cite this DOI

Longman Publishers (2020). Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles. *Journal of Science & Technology*, 173–187. https://doi.org/10.46243/jst.2020.v5.i4.pp173-187

@article{anon2020formulation,
  title     = {{Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles}},
  journal   = {Journal of Science \& Technology},
  year      = {2020},
  month     = {jul},
  number    = {Volume 5},
  pages     = {173--187},
  publisher = {Longman Publishers},
  issn      = {2456-5660},
  doi       = {10.46243/jst.2020.v5.i4.pp173-187},
  url       = {https://doi.org/10.46243/jst.2020.v5.i4.pp173-187},
  language  = {en},
  abstract  = {Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 \&F127) and co-solvent (Tween80) were chosen \& the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, \% drug loading and stability.Result:Mixed micelle (hydrophobic \&hydrophilic) obtained from optimized batch shows the highest entrapment of 29\%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination}
}

TY  - JOUR
TI  - Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles
JO  - Journal of Science & Technology
PY  - 2020
DA  - 2020/07/30/
IS  - Volume 5
SP  - 173
EP  - 187
PB  - Longman Publishers
SN  - 2456-5660
LA  - en
AB  - Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination
DO  - 10.46243/jst.2020.v5.i4.pp173-187
UR  - https://doi.org/10.46243/jst.2020.v5.i4.pp173-187
ER  -

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    "id": "10.46243/jst.2020.v5.i4.pp173-187",
    "DOI": "10.46243/jst.2020.v5.i4.pp173-187",
    "URL": "https://doi.org/10.46243/jst.2020.v5.i4.pp173-187",
    "title": "Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles",
    "source": "Smart Scholars DOI Registry",
    "container-title": "Journal of Science & Technology",
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    "issue": "Volume 5",
    "page": "173-187",
    "publisher": "Longman Publishers",
    "language": "en",
    "abstract": "Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination",
    "ISSN": "2456-5660"
}

From the record as registered (version 2) — the record and its history. Programs: https://registry.smartscholars.in/api.php?action=cite&doi=10.46243%2Fjst.2020.v5.i4.pp173-187 gives all four in one JSON answer.