10.46243/jst.2024.v9.i2.pp72-110 registered
Therapeutic Targeting of the SIRT1-SREBP Pathway in Metabolic Disorders
Resolves to https://jst.org.in/index.php/pub/article/view/1460
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2024.v9.i2.pp72-110
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 1042706a6655dc1f…
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What the DOI identifies
JournalArticle — an article in a journal · Digital · Visual · en
Therapeutic Targeting of the SIRT1-SREBP Pathway in Metabolic Disorders (PrincipalTitle)
Published 2024-02-02
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 09 · issue 02 · pages 72
Agents
- B Sandhya Rani (author)
- I. Triveni (author)
- B.Revathi (author)
- N. Danamurthy (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2024.v9.i2.pp72-110
Abstract
The enzymes known as sirtuins, or silent information regulator 2, are histone deacetylases that depend on nicotinamide adenine dinucleotide (NAD+). In addition to its well-established role in prolonging longevity, further study is necessary to examine the beneficial effects of Sirtuin 1 (SIRT1), a member of the sirtuin group, on lipid metabolism. SIRT1 has been extensively associated with the control of gene expression. The SIRT1 substrate sterol regulatory element-binding protein (SREBP) has garnered a lot of attention because of its involvement in a number of biological processes, such as metabolic activities, DNA damage repair, and cell cycle control. Therefore, the aim of this investigation was to examine and clarify the relationship between SIRT1 and SREBPs and evaluate the role of SIRT1/SREBPs in reducing dysfunction in lipid metabolism. Investigating whether SIRT1 and SREBPs may be used as feasible targets for therapeutic intervention in the management of diabetic complications was the aim of this study.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2024.v9.i2.pp72-110 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Therapeutic Targeting of the SIRT1-SREBP Pathway in Metabolic Disorders (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: B Sandhya Rani author: I. Triveni author: B.Revathi author: N. Danamurthy publisher: Longman Publishers published: 2024-02-02 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 09 · no. 02 · pp. 72 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-08-26 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
complete Every System Metadata element is here, with the basic metadata a journal article needs.
The System Metadata Declaration (JSON) · the Kernel Metadata Declaration (XML) · what each sub-type needs
History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 610 fields set · sha256 fcf3491e3048… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
Machine-readable: the history as JSON, with the full record after each change.
