10.46243/jst.2021.v6.i04.pp206-215 registered
Identification of differentially expressed signature genes of PCOS under vitamin D deficiency and oxidative stress: A bioinformatics Analysis
Resolves to https://www.jst.org.in/index.php/pub/article/view/620
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2021.v6.i04.pp206-215
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 2c978a9c2b8561fd…
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JournalArticle — an article in a journal · Digital · Visual · en
Identification of differentially expressed signature genes of PCOS under vitamin D deficiency and oxidative stress: A bioinformatics Analysis (PrincipalTitle)
Published 2021-08-31
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 06 · issue 04 · pages 206–215
Agents
- Aurobinda Das (author)
- Pallavi Mishra (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2021.v6.i04.pp206-215
Abstract
Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders in women of reproductive age. However, there is a lack of genetic study of the internal mechanisms of PCOS. In this study we have identified core genes involved in the pathogenesis of PCOS by using bioinformatics analysis. For this study, the dataset GSE40400 was collected from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were obtained by using the R package limma. We analysed the microarray dataset GSE40400 to identify DEGs of PCOS subjects with VD deficiency under oxidative stress. After applying the available numerical expression values, we 617 novel DEGS out of which 183 up-regulated and 434 were down-regulated). Out of them 144 novel DEGS related exclusively to oxidative stress (39 up-regulated and 105 down-regulated), 39 novel DEGS related exclusively to vitamin D deficiency (12 up-regulated and 27 down-regulated) and 160 novel DEGS related exclusively to oxidative stress and vitamin D deficiency (48 up-regulated and 112 down-regulated). The functional analysis was carried out by using DAVID database and software tools for the identified up-regulated and down-regulated DEGs.
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| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2021.v6.i04.pp206-215 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Identification of differentially expressed signature genes of PCOS under vitamin D deficiency and oxidative stress: A bioinformatics Analysis (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: Aurobinda Das author: Pallavi Mishra publisher: Longman Publishers published: 2021-08-31 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 06 · no. 04 · pp. 206–215 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-09-10 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
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| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 132 fields set · sha256 2a148fce8659… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
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