10.46243/jst.2020.v5.i5.pp119-129 registered
Formulation, Development and Evaluation of Topiramate Loaded Niosomes for the Treatment of Epilepsy
Resolves to https://www.jst.org.in/index.php/pub/article/view/313
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2020.v5.i5.pp119-129
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 fbc77056cd19067a…
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What the DOI identifies
JournalArticle — an article in a journal · Digital · Visual · en
Formulation, Development and Evaluation of Topiramate Loaded Niosomes for the Treatment of Epilepsy (PrincipalTitle)
Published 2020-10-12
Part of Journal of Science & Technology · ISSN 2456-5660 · issue Volume 5 · pages 119–129
Agents
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2020.v5.i5.pp119-129
Abstract
Topiramate (TPM) is an anti-epileptic drug used in the treatment of epilepsy and seizures. The study was designed with three aims. First, to enhance the solubility and bioavailability of BCS class III drug TPM; second, to ease administration of the formulation to the epileptic patient, during an attack, and third, to decrease the dose of drug for enduring treatment. Formulation of TPM niosomes was optimized by changing the concentration of Tween, Labrafil and cholesterol using response surface design. Further the TPM niosomes were prepared by using ether injection method. The formulation was then evaluated for vesicle size, entrapment efficiency and in-vitro drug release study. FTIR and DSC studies were performed for pure drug and optimized batch. The vesicle size of the optimized batch was found to be 0. 35 nm. The %entrapment efficiency and %drug release of optimized batch was found to be 94.64% and 92.027% respectively. From the present study it can be concluded that the developed niosomes of TPM has shown great potential in treatment of epilepsy.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2020.v5.i5.pp119-129 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Formulation, Development and Evaluation of Topiramate Loaded Niosomes for the Treatment of Epilepsy (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | publisher: Longman Publishers published: 2020-10-12 part of: Journal of Science & Technology · ISSN 2456-5660 · no. Volume 5 · pp. 119–129 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2020-09-24 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
complete Every System Metadata element is here, with the basic metadata a journal article needs.
Recommended for a journal article and not in this record: its author(s), editor(s) or corporate author · the volume number.
The System Metadata Declaration (JSON) · the Kernel Metadata Declaration (XML) · what each sub-type needs
History — the ledger
Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 96 fields set · sha256 ddadf8c274af… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: titles.0.value: |
Machine-readable: the history as JSON, with the full record after each change.
