10.46243/jst.2020.v5.i04.pp223-229 registered
Lumefantrine Solid Dispersion Formulation Development and Characterization with Piperine for Solubility Enhancement
Resolves to https://www.jst.org.in/index.php/pub/article/view/666
Held by Longman Publishers (India) · prefix 10.46243 live · DOI address https://doi.org/10.46243/jst.2020.v5.i04.pp223-229
Registered 29 Sep 2026 via crossref · record version 2 · last change 29 Sep 2026, 11:59 PM · record sha256 cd79f873584370bd…
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JournalArticle — an article in a journal · Digital · Visual · en
Lumefantrine Solid Dispersion Formulation Development and Characterization with Piperine for Solubility Enhancement (PrincipalTitle)
Published 2020-08-27
Part of Journal of Science & Technology · ISSN 2456-5660 · volume 05 · issue 04 · pages 223–229
Agents
- Dr.Rafia (author)
- Dr.Ratnasree (author)
- Nethikoppula Pravallika (author)
- Longman Publishers (publisher)
Identifiers DOI 10.46243/jst.2020.v5.i04.pp223-229
Abstract
Lumefantrine's limited water solubility and variable bioavailability are linked to its crystallinity and efflux mediated by P-glycoprotein (P-gp). Here, amorphous solid dispersions (SD) of lumefantrine (LUMF) including piperine (PIP), a P-gp and CYP3A4 inhibitor, were produced using Copovidone/Kollidon® VA 64 (KOL) at three different ratios with increasing polymer content in order to increase the dissolution and, therefore, the oral bioavailability. Using DSC, FTIR, and XRD, the PIP-LUMF-KOL SD at a ratio of 1:6:18 showed increased aqueous solubility of LUMF. While FTIR tests looked into potential intermolecular interactions between LUMF and PIP and/or KOL, the DSC thermogram and XRD diffractogram of LUMF-PIP-SD validated the enhanced dissolving brought on by LUMF's loss of crystallinity. The stability of LUMFPIP-Sol SD under stressful temperature and humidity conditions for 90 days was confirmed by DSC and dissolving studies. Overall, the findings point to the possibility that increasing the SD of LUMF combined with P-gp inhibitor PIP may improve solubility and, in turn, increase LUMF's bioavailability.
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Each element by the standard's name (Annex B: reference elements, then administrative) and the Handbook's (in grey), read off the record above.
| Element | Value | In the record |
|---|---|---|
| DOI Name DOI name | 10.46243/jst.2020.v5.i04.pp223-229 | doi |
| Referent Type referentType | Creation | referent |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal | type |
| Referent Name(s) referentName(s) | Lumefantrine Solid Dispersion Formulation Development and Characterization with Piperine for Solubility Enhancement (PrincipalTitle, en) | titles |
| Basic Metadata basicMetadata | author: Dr.Rafia author: Dr.Ratnasree author: Nethikoppula Pravallika publisher: Longman Publishers published: 2020-08-27 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 05 · no. 04 · pp. 223–229 language: en form: Digital · Visual · Language | agents, dates, container, language, structural_type, modes, characters |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI | identifiers, relations (IsSameAs) |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy | record.source_agency (our code, ra_doi_name, for names issued here once appointed) |
| Created Date issueDate | 2026-09-10 | record.registered (when the DOI name was first registered) |
| relatedIdentifiers | none needed — the descriptive metadata is in this record | container, relations (only where the descriptive metadata lives at another identifier) |
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Every change to this DOI, in order, as it was recorded. Entries are only ever added, never changed or removed.
| # | When | What | By | Changes |
|---|---|---|---|---|
| 1 | 29 Sep 2026, 10:00 PM | register registered at Crossref; record read from api.crossref.org | Administrator (admin) | 92 fields set · sha256 7d44d9ce5d5f… |
| 2 | 29 Sep 2026, 11:59 PM | update record re-read from api.crossref.org | Administrator (admin) | container.titles.0.value: |
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