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    "title": "Absorbance ratio and Concentration Ratio-Based Spectrophotometric Methods for the Determination of Triprolidine and Pseudoephedrine Combination in Tablets",
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            "value": "In this research a streamlined and economical UV spectrophotometric approach have been successfully developed to simultaneously measure triprolidine hydrochloride (TRI) and pseudoephedrine hydrochloride (PSE). This analytical strategy was specifically designed to handle both bulk raw materials and pharmaceutical tablet formulations, offering a practical solution for laboratories that require high-quality results but may have limited access to complex instrumentation like HPLC. The study introduced two distinct mathematical methods to resolve the common challenge of overlapping light absorption spectra between these two drugs. Both techniques utilize 0.1 M hydrochloric acid as the solvent and rely on absorbance readings taken at specific wavelengths of 257 nm and 290 nm. Method A establishes a relationship based on concentration and absorbance ratios, while Method B applies an absorbance factor to mathematically correct for the spectral overlap of the components. To ensure the reliability of these procedures, both methods were rigorously validated according to ICH guidelines. The results demonstrated a high degree of linearity, with correlation coefficients exceeding 0.999 for both TRI (at concentrations of 6–30 μg/mL) and PSE (at 144–720 μg/mL). Furthermore, the methods proved to be highly precise, maintaining a relative standard deviation of less than 2%, and accurate, with recovery rates consistently near 100%. Statistical analysis confirmed that there is no significant performance difference between the two proposed techniques. Consequently, these UV spectrophotometric procedures serve as a simple, dependable, and efficient tool for the routine quality control of triprolidine and pseudoephedrine combinations in pharmaceutical settings.",
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                "unstructured": "Abu Reid, I.O. and Yousif, M.M.E., 2023. Absorbance subtraction method for the determination of losartan potassium and hydrochlorothiazide in bulk and tablets. Asian Journal of Pharmaceutical Analysis, 13, pp.243–248. Available at: https://doi.org/10.52711/2231-5675.202 3.00040"
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                "unstructured": "Bassuoni, Y.F., Essam, H.M., Elzanfaly, E.S., Zaazaa, H.E. and Kelani, K.O., 2019. Ecofriendly determinations of pseudoephedrine HCl and triprolidine HCl in their tablet form: Evaluation of dissolution profile. ChemistrySelect, 4(31), pp.8946–8952. Available at: https://doi.org/10.1002/slct.201901222"
            },
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                "key": "ref3",
                "unstructured": "Dinc, E. and Onur, F., 1998. Comparison of ratio spectra derivative spectrophotometry and Vierordt's method applied to quantitative analysis of pseudoephedrine hydrochloride and triprolidine hydrochloride in tablets. STP Pharma Sciences, 8(3), pp.203–208"
            },
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                "key": "ref4",
                "doi": "10.5530/phm.2015.6.12",
                "unstructured": "Hinge, M.A., Patel, K.R. and Mahida, R.J., 2015. Spectrophotometric and high performance liquid chromatographic determination (HPLC) of triprolidine and pseudoephedrine hydrochloride in tablet dosage form. Pharmaceutical Methods, 6(2), pp.87–93. Available at: https://doi.org/10.5530/phm.2015.6.12"
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                "unstructured": "International Council for Harmonisation, 2023. ICH Q2(R2): Validation of Analytical Procedures, Step 4 Guideline. Geneva: International Council for Harmonisation"
            },
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                "key": "ref6",
                "unstructured": "Moharan, R.A., Kawathekar, N. and Chaturvedi, S., 1996. Simultaneous spectrophotometri c estimation of triprolidine hydrochloride and pseudoephedrine hydrochloride in pharmaceutical dosage form. Indian Journal of Pharmaceutical Sciences, 58(3), pp.93–95"
            },
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                "doi": "10.1134/s1061934810010077",
                "unstructured": "Onmez, O.A., Bozdogan, A., Kunt, G. and Div, Y., 2007. Spectrophotometric multicomponent analysis of a mixture of triprolidine hydrochloride and pseudoephedrine hydrochloride in pharmaceutical formulations by partial least-squares multivariate calibration. Chemical Analysis, 52(1), pp.135–140"
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                "doi": "10.4103/0975-1483.66791",
                "unstructured": "Patel, C.V., Khandhar, A.P., Captain, A.D. and Patel, K.T., 2007. Validated absorption factor spectrophotometric and reversed-phase high-performance liquid chromatographic methods for the determination of ramipril and olmesartan medoxomil in pharmaceutical formulations. E Eurasian Journal of Analytical Chemistry, 2, pp.160–171"
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                "key": "ref9",
                "doi": "10.7439/ijapa",
                "unstructured": "Reid, I.O. and Widaa, A.T., 2017. Spectrophotometric method for the simultaneous determination of pseudoephedrine and triprolidine in bulk and tablet forms. International Journal of Advanced Pharmaceutical Analysis, 7, pp.21–23. Available at: https://doi.org/10.7439/ijapa"
            },
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                "key": "ref10",
                "unstructured": "Sriphong, L., Chaidedgumjorn, A. and Chaisuroj, K., 2009. Derivative spectrophotometry applied to the determination of triprolidine hydrochloride and pseudoephedrine hydrochloride in tablets and dissolution testing. World Academy of Science, Engineering and Technology, 32, pp.569–573"
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                "unstructured": "Sweetman, S., 2009. Martindale: The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press"
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                "doi": "10.31788/rjc.2023.1618072",
                "unstructured": "Tarigan, R.E., Sianturi, D.M. and Nadya, S., 2023. Determination of pseudoephed rine hydrochloride and triprolidine hydrochloride simultaneously by using area under curve spectrophotometry ultraviolet. Rasayan Journal of Chemistry, 16(1), pp.223–226. Available at: https://doi.org/10.31788/rjc.2023.1618072"
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                "unstructured": "United States Pharmacopeia Convention, 2010. United States Pharmacopoeia/National Formulary. 24th ed. Rockville, MD: United States Pharmacopeia Convention"
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