{ "ok": true, "doi": "10.46243/jst.2025.v10.i7.pp13-28", "doi_display": "10.46243/jst.2025.v10.i7.pp13-28", "doi_url": "https://doi.org/10.46243/jst.2025.v10.i7.pp13-28", "state": "registered", "url": "https://www.jst.org.in/index.php/pub/article/view/1375", "title": "Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation", "version": 2, "registered_via": "crossref", "prefix": { "prefix": "10.46243", "status": "live" }, "registrant": { "name": "Longman Publishers", "kind": "publisher", "country": "India" }, "reserved_at": null, "registered_at": "2026-09-29 22:00:32", "updated_at": "2026-09-29 23:59:51", "withdrawn_at": null, "withdrawn_reason": null, "record": { "format": "smartscholars-doi-metadata/1.0", "doi": "10.46243/jst.2025.v10.i7.pp13-28", "referent": "Creation", "type": "JournalArticle", "structural_type": "Digital", "modes": [ "Visual" ], "characters": [ "Language" ], "titles": [ { "value": "Analyzing Different Cardiovascular Medication Combinations with Vincamine: A Simple, Simultaneous, and Environmentally Friendly Evaluation", "type": "PrincipalTitle", "lang": "en" } ], "identifiers": [ { "type": "DOI", "value": "10.46243/jst.2025.v10.i7.pp13-28" } ], "agents": [ { "role": "author", "name": { "given": "", "family": "K.SARASIRISHA" }, "sequence": "first" }, { "role": "author", "name": { "given": "", "family": "D CHAITANYA DIXIT" }, "sequence": "additional" }, { "role": "author", "name": { "given": "", "family": "P.T.NAGARAJU" }, "sequence": "additional" }, { "role": "author", "name": { "given": "", "family": "B Akhila" }, "sequence": "additional" }, { "role": "author", "name": { "given": "", "family": "E Nagadeepthi" }, "sequence": "additional" }, { "role": "publisher", "name": { "org": "Longman Publishers" } } ], "dates": { "published": "2025-07-01", "date_type": "PublicationDate", "online": "2025-07-01" }, "language": "en", "container": { "type": "Journal", "titles": [ { "value": "Journal of Science & Technology", "type": "PrincipalTitle" } ], "identifiers": [ { "type": "ISSN", "value": "2456-5660", "medium": "electronic" } ], "volume": "10", "issue": "07", "pages": { "first": "13", "last": "28" } }, "links": [ { "url": "https://www.jst.org.in/index.php/pub/article/view/1375", "return_type": "text/html", "primary": true }, { "url": "https://www.jst.org.in/index.php/pub/article/download/1375/1021", "purpose": "text-mining", "return_type": "application/pdf" }, { "url": "https://www.jst.org.in/index.php/pub/article/download/1375/1178", "purpose": "text-mining", "return_type": "application/xml" }, { "url": "https://jst.org.in/index.php/pub/article/view/1375/1021", "purpose": "similarity-checking" } ], "abstract": { "value": "It is crucial for sustainable pharmaceutical analysis to develop two environmentally friendly analytical methods that can simultaneously determine eight cardiovascular drugs: hydrochlorothiazide (HCT), captopril (CPL), lisinopril (LSP), valsartan (VAL), atorvastatin (ATR), bisoprolol (BSL), amlodipine (AML), and carvedilol (CVL). Additionally, the nutraceutical vincamine (VIC) should be tested. Micellar Electro Kinetic Chromatography (MEKC) and High-Performance Liquid Chromatography (HPLC) are investigated in this work as potential tools for this objective. The MEKC technique separates substances by using fused silica capillaries with an internal diameter of 41.5 cm and a background electrolyte that includes 50 mM borate buffer with a pH of 9, 50 mM sodium lauryl sulfate (SLS), and 10% Acetonitrile. A ZORBAX Extend- C18 column, measuring 4.6 × 250 mm and having a particle size of 5 µm, was used for separation in the HPLC technique. The mobile phase, which consisted of methanol and 50 mM phosphate buffer pH 3, was used in the gradient. With minimal values of LOD and LOQ, both techniques achieved high linearity (r > 0.9996). Both approaches were effective in identifying the examined medications’ co-administered single, binary, and ternary dose forms. As an added bonus, different combinations of co-administered dose forms in rat plasma, proving the techniques’ viability in various matrices. In line with green chemistry principles, micellar solutions are used in MEKC to increase separation efficiency and decrease organic solvent use. To minimize toxicity and waste, HPLC procedures were fine-tuned utilizing solvents that are safe for the environment. To make sure the approaches were completely sustainable, we looked at their ecological effect, safety, and practical efficiency using green, white, and blue criteria. The techniques were perfect for frequent usage in pharmaceutical analysis since they were costeffective, time-saving, and attained excellent efficiency, sensitivity, and repeatability", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2025-07-01", "applies_to": "vor" }, "references": [ { "key": "ref1", "unstructured": "Cardiovascular disorders, 2024, World Health Organization (WHO). P. 1" }, { "key": "ref2", "unstructured": "Diabetes mellitus type 2 (CVD) by Olvera Lopez, Ballard, and Jan. The Treasure Island (FL) is a 2024 StatPearls property" }, { "key": "ref3", "unstructured": "The name of the organization is the U.S. Food and Drug Administration’s Center for Drug Evaluation and Research, or CDER" }, { "key": "ref4", "unstructured": "Fourth, Gaziano et al. Heart illness [CVD]. The editors of this work are Jamison, Breman, Measham, Alleyne, Claeson, Evans, and DB. The top priority in emerging nations for disease control. 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The exact citation is: J Cell Immunol. 2020;2(5):211-9" }, { "key": "ref9", "doi": "10.1016/j.talanta.2011.01.066", "unstructured": "Mohamed NA, Atia NN, and Ahmed S. Combinations of antihypertensive drugs may be determined simultaneously using a dual-mode separation technique and HPLC. The article is published in Talanta and has the DOI: 84(3):666-" }, { "key": "ref10", "unstructured": "Cardso, MA; Hess, BS; Gasparetto, JC; Pontarolo, R. (2010). Using a validated HPLC approach, the pharmaceutical tablet containing captopril, hydrochlorothiazide, and their associated chemicals may be determined simultaneously. Bashat EA, et al" }, { "key": "ref11", "doi": "10.1016/j.microc.2022.107740", "unstructured": "(2011) published in the Latin American Journal of Pharmacy, volume 30, issue 10, pages 1901–1909. We developed and validated an environmentally friendly HPLC approach that does not use organic solvents to measure many antihypertensive combinations at once. 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