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    "title": "Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A MultiParametric Approach",
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            "value": "n this study, we used the neutrophil granulocytes functional activity model to examine oxidative stress indicators, antioxidant protection, lipid peroxidation, and T1D in children. According to research, children with type 1 diabetes show heightened lipoperoxidation and antioxidant defense system activation in response to reactive oxygen species (ROS) damage, which includes bidirectional alterations in non-enzymatic pathways. The development of tolerance to oxidative stress in children with compensated type 1 diabetes is indicated by the coordinated synthesis of reactive oxygen species and oxygen-dependent blood cell metabolism. In children with decompensated type 1 diabetes, it is indicated that the third stage of oxidative stress, which involves the depletion of insulin-producing β-cells, begins with a decrease in reactive oxygen species production, a decrease in the activation of the phagocyte oxygen-dependent metabolism, and incomplete phagocytosis mechanisms. The severity of metabolic problems in children with type 1 diabetes is influenced by the level of the antioxidant defense system's \"respiratory explosion\" of neutrophilic granulocytes.",
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                "unstructured": "One source is Becker’s Principles and Practice of Endocrinology and Metabolism, which was published in 2001 by Lippincott Williams & Wilkins in Philadelphia and has 2477 pages"
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                "key": "ref2",
                "doi": "10.1515/jpem.2009.22.7.635",
                "unstructured": "Glycation and lipid peroxidation in children and adolescents with type 1 diabetes mellitus and diabetic sequelae, by Kostolanska J., Jakus V., and Barak L. Publication: 2009, Journal of Pediatric Endocrinology and Metabolism, Volume 22, Issue 7, Pages 635-643"
            },
            {
                "key": "ref3",
                "doi": "10.1042/cs20050025",
                "unstructured": "The involvement of endothelial dysfunction in vascular consequences in diabetes mellitus (Schalkwijk et al., 2022). The citation is from Clin. Sci (Lond). 2005, volume 109, issue 2, pages 143-959"
            },
            {
                "key": "ref4",
                "doi": "10.2337/diacare.21.9.1414",
                "unstructured": "Fourth, Herman W.H., Aubert R.E., and King H. Diabetes worldwide: incidence, prevalence, numerical estimates, and predictions, 1995–2025. The citation for this article is Diabetes Care, 1998, volume 21, issue 9, pages 1414–1431"
            },
            {
                "key": "ref5",
                "doi": "10.25207/1608-6228-2018-25-4-22-36",
                "unstructured": "Bykov I.M., Domenyuk D.A., Dmitrienko S.V., Ivanyuta S.O., Budaychiev G. M-A. Analyzing the cariogenic condition in children with type 1 diabetes mellitus, taking into consideration the enamel resistance and mineralizing capacity of saliva. Publication: Kubanskij nauchnyj medicinskij vestnik. 2018; 25(4): 22-36. English abstract of a Russian text. This publication has the DOI 10.25207 / 1608-6228-2018-25-4-22-"
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                "key": "ref6",
                "unstructured": "The authors of the article are Domenyuk, Zelensky, Rzhepakovsky, Anfinogenova, and Pushkin. Investigating metabolic abnormalities in bone tissue in children with autoimmune diabetes mellitus via the use of laboratory and x-ray gentral investigations for early diagnostic purposes. Applied Science Letters in Entomology. 2018; 5(4): 1-12"
            },
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                "key": "ref7",
                "unstructured": "The authors of the article are Domenyuk, Zelensky, Dmitrienko, Anfinogenova, and Pushkin. Diabetes mellitus type 1 in children: phosphorine calcium exchange peculiarities in dental caries etiology. Research in Applied Science and Entomology. 2018; 5(4): 49-64"
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                "unstructured": "This sentence is a citation for a work by Domenyuk, Konnov, Pichugina, Anfinogenova, Goncharenko, and Pushkin. Quantitative and qualitative assessment of demineralization of tooth enamel using microcomputed tomography. Annals of Entomology and Applied Science, Volume 5, Issue 4, Pages 72–83, 2018"
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                "key": "ref9",
                "doi": "10.25207/1608-6228-2017-24-4-39-48",
                "unstructured": "This sentence is a citation for a paper by Bykov et al., which was published in 2009. Salivary levels of proinflammatory cytokines in patients with M Kishore Babu, T Pavani, D Divyasri, P Krupa Rani: Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A Multi Parametric Approach autoimmune diabetes mellitus at various stages of endocrinopathy. The article is published in the 2017 volume of the Kuban Scientific Medical Bulletin and runs columns 39–48. (With an English abstract and a Russian translation). Publication information: 10.25207/1608-6228- 2017-24-4-39-48"
            },
            {
                "key": "ref10",
                "unstructured": "Assessing the status of periodontal tissues in children with type 1 diabetes mellitus: clinical and diagnostic importance of matrix metalloproteinase activity and their tissue inhibitors (Davydov B.N., Gilmiyarova F.N., Domenyuk D.A., Ivchenko L.G.). Chapter One: Preventative Dental Care for Children. 2017; Volume XVI, Issue 64, Pages 14–19. Translated into Russian"
            },
            {
                "key": "ref11",
                "unstructured": "Davydov B.N., Gilmiyarova F.N., Domenyuk D.A., and Ivchenko L.G. Evaluation of periodontal tissues in adolescents with type 1 diabetes mellitus: clinical and diagnostic relevance of matrix metalloproteinase and their tissue inhibitor activities. Section II. Preventative dental care for children and adolescents. 2018; Vol. XVII; 1 (64): 37-46. Translated into Russian"
            },
            {
                "key": "ref12",
                "doi": "10.25636/pmp.1.2019.1.1",
                "unstructured": "Diavdov B.N., Domenyuk D.A., and Dmitrienko S.V.: Periodont tissues microcirculation in children of critical age groups with adequate type 1 diabetes. Section One. Periodontology. 2019; 24(90): 4–10. 10.25636/PMP.1.2019.1.1 (Available Online)"
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                "key": "ref13",
                "doi": "10.33925/1683-3759-2019-24-2-108-119",
                "unstructured": "Davydov B.N., Domenyuk D.A., and Dmitrienko S.V.: Periodont tissues microcirculation in sufficient type 1 diabetic children of critical age groups. Periodontology (Part II) [2019];24(2):108–"
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                "key": "ref14",
                "unstructured": "(Using Russian.) 10.1352/1683-2759- 2019-24-2-108-119 will do"
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                "key": "ref15",
                "doi": "10.33925/1683-3031-2019-19-69-26-38",
                "unstructured": "The authors are Davydov B.N., Domenyuk D.A., Dmitrienko S.V., Korobkeev А.A., and Arutyunova A.G. Clinical and diagnostic methods for the treatment of dental abnormalities in children throughout the developmental period, as well as the morphological features of the face skeleton. Vol. 19, No. 69, pages 26–38, Pediatric Dentistry and Prophylaxis, 2019. [In Russian] DOI: 10.33925/1683-3031-2019-19-69-26-38"
            },
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                "key": "ref16",
                "doi": "10.25636/pmp.3.2018.4.12",
                "unstructured": "Menendyuk, D.A., and Davydov, B.N. Possibilities of microcomputer tomography in the diagnosis of early forms of caries of a chewing surface of permanent molars in children. First Section: Preventative Dental Care for Children (Volume 18, Issue 67, 2018): 61–64. (In Russian) DOI: 10.25636/PMP.3.2018.4.12"
            },
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                "key": "ref17",
                "doi": "10.33925/1683-3031-2019-19-2-04-12",
                "unstructured": "Bogdanov B.N. and Domenyuk D.A. Possibilities of microcomputer tomography in the diagnosis of early forms of caries of a chewing surface of permanent molars in children. Volume 19, Issue 70, Pages 4-12, 2019 (Part II): Pediatric Prophylaxis and Dental Care. (Read in Russian.) DOI: 10.33925/1683-3031-2019-19-2-04-12"
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                "key": "ref18",
                "unstructured": "An analysis of the diagnostic and prognosis significance of crystalline formations in the oral fluid of children with occlusion abnormalities was conducted by Domenyuk, Davydov, Gilmiyarova, Ivchenko, and Vedeshina. Dental hygiene and preventive care for children. 2017; Vol. XVII, No. 61: 9-16. Translated into Russian"
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                "key": "ref19",
                "doi": "10.14300/mnnc.2017.12117",
                "unstructured": "The following is an abstract from an article published in 2017 in the Medical News of North Caucasus: Kulikova, N.G., Domenyuk, D.A., Zelensky, V.A., and Tkachenko, A.S. Assessment of the efficacy of pharmaco-physiotherapeutic treatment of catarrhal gingivitis on outcomes of the oral cavity mucosal immunity in postpartum women. The article is page 417–421. (With an English abstract and a Russian translation). DOI: 10.14300/mnnc.2017.12117"
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                "key": "ref20",
                "doi": "10.35630/2199-885x/2018/8/2/71",
                "unstructured": "Domenyuk D.A., Porfyriadis М.Р., and Budaychiev G. M-A. Modern methodologies for the detection of abnormalities in bone tissue in youngsters afflicted with type 1 diabetes. The article is published in Archiv EuroMedica (2018) and features on pages 71 to 81"
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                "key": "ref21",
                "unstructured": "Gavrilova Vasiliyevich, Domenyuk Victor A. Characteristics of microbiome in the mouth in children with fixed orthodontic braces. The article is published in Archiv EuroMedica (2018) with pages 91–92"
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                "key": "ref22",
                "unstructured": "Domenyuk D.A., Gavrilova А.А. Verification of thermoplastics’ microbiological safety for use in children’s prosthetic dentistry. Paper published in Archiv EuroMedica in 2018 with the DOI: 8.2 makes reference to pieces 88–90"
            },
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                "key": "ref23",
                "doi": "10.25207/1608-6228-2017-2-73-82",
                "unstructured": "Identification of immunometabolic diseases in children diagnosed with type I diabetes mellitus (Ivchenko L.G., Domenyuk D.A.). Published in 2017 by Kuban Scientific Medical Bulletin, volume 1, issue 2, pages 73–82. (With an English abstract and a Russian translation). Bibcode: 10.25207/1608-6228-2017-2-73-82"
            },
            {
                "key": "ref24",
                "unstructured": "Part I of the article “Influence of severity of type I diabetes mellitus on dental status and immunological and biochemical parameters of blood serum and oral fluid” was published M Kishore Babu, T Pavani, D Divyasri, P Krupa Rani: Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A Multi Parametric Approach in 2017 in the journal Periodontology and authored by F.N. Gilmiyarova, B.N. Davydov, D.A. Domenyuk, and L.G. Ivchenko. The article spans pages 53-60. Translated into Russian"
            },
            {
                "key": "ref25",
                "unstructured": "Part II of the article “Influence of severity of type I diabetes mellitus in children on dental status and immunological and biochemical parameters of blood serum and oral fluid” published in 2017 by Vol. XXII, Issue 844, pages 36–41 in Russian, was written by Gilmiyarova, Davydov, Domenyuk, and Ivchenko"
            },
            {
                "key": "ref26",
                "unstructured": "Indicators of buccal epithelium responsiveness as markers of morphological and functional deterioration in patients with dentoalveolar disease (Vedeshina E.G., Domenyuk D.A.). Journal of Kuban Scientific Medical Research. 2016; 4(4): 23-32. (With an English abstract and a Russian translation). Citation: 10.25207/1608- 6228-2016-4-23-32"
            },
            {
                "key": "ref27",
                "doi": "10.1016/s0140-6736(01)05415-0",
                "unstructured": "The article “Type I diabetes: new perspectives on disease pathogenesis and treatment” was published in 2001 by Lanset and was coauthored by Atkinson and G.S. Eisenbarth. It can be found on pages 221-229"
            },
            {
                "key": "ref28",
                "doi": "10.2337/diacare.21.9.1414",
                "unstructured": "The worldwide impact of diabetes from 1995 to 2025: prevalence, numerical estimates, and forecasts (King, Aubert, and Herman, 1997). The journal Diabetes Care published an article in 1998 with the DOI: 21;9: 1414–1431"
            },
            {
                "key": "ref29",
                "unstructured": "Diabetes: Worldwide Prevalence Estimates and Forecasts, 1994–2010, by Mc Carty and Zimmet, page 28. Article 29 from the International Diabetes Institute in 1994"
            },
            {
                "key": "ref30",
                "doi": "10.3164/jcbn.11-014fr",
                "unstructured": "Ohnaka K., Takayanagi R., and Inoguchi T. Scientific and clinical data point to oxidative stress as a component that worsens diabetes mellitus. Clinical and Laboratory Nutrition, 2010; 48(1): 72-77"
            },
            {
                "key": "ref31",
                "unstructured": "Regarding the causes of IDDM, J. Nerup wrote an article for Diabetologia in 1994, specifically in Volume 37, Supplement 2, pages 82–89"
            },
            {
                "key": "ref32",
                "unstructured": "Angiopathy and oxidative stress in diabetes mellitus (Dedov et al., 2018). Balabolkin et al. Pages 86–32. Moscow, 2003"
            },
            {
                "key": "ref33",
                "doi": "10.1134/s1990747811020097",
                "unstructured": "Diabetes mellitus: metabolic consequences and oxidative stress, by I.B. Zavodnуk, I.K. Dremza, and E.A. Lapshina. The article is published in the Journal of Membrane and Cell Biology in 2011 and features pages 83–94"
            },
            {
                "key": "ref34",
                "unstructured": "Oxidative stress in endocrine-based reproductive problems in women (Kolesnikova L.I., Osipova E.V., Grebenkina L.A., 33). Science, Novosibirsk, 2011, 116 pages"
            },
            {
                "key": "ref35",
                "doi": "10.25207/1608-6228-2017-24-4-27-38",
                "unstructured": "Researchers Bykov, Ivchenko, Domenyuk, Kostyukova, Storozhuk, and Ilijev conducted the study. Characteristics of oxidation by free radicals and safeguarding antioxidants in children with type 1 sugar diabetes. Journal of Kuban Scientific Medical Research. 2017; 4(4): 27-38. (With an English abstract and a Russian translation)"
            },
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                "key": "ref36",
                "unstructured": "This sentence is a DOI (Digital Object Identifier) for a publication by Davydov, Gilmiyarova, Domenyuk, and Ivchenko. Development of more precise methods for detecting type I diabetes in children by analyzing oxidative stress in the mouth and cytomorphological findings from buccal epithelial investigations. Volume XVI, Issue 62, Pages 9–18, Pediatric Dentistry and Prophylaxis (in Russian)"
            },
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                "key": "ref37",
                "unstructured": "This sentence is a paraphrase of an article by Domenyuk, Davydov, Dmitrienko, Sumkina, and Budaychiev. The experimental examination of changes in the morphological condition of paradontal complex tissues during the dynamics of orthodontic tooth transfer. Volume 23, Issue 1, Page 69–78, Journal of Periodontology, 2018"
            },
            {
                "key": "ref38",
                "doi": "10.25636/pmp.1.2018.3.1",
                "unstructured": "Davydov B.N., Domenyuk D.A., Bykov I.M., Ivchenko L.G., and Dmitrienko S.V. Recent advances in biomedical imaging for preclinical periodontal disease risk assessment in type 1 diabetic children: a clinical, laboratory, and X-ray study. Chapter One. (In Russian) Periodontology, 2018; Vol. XXIV, 3-24 (88): 4-11. Publication date: 10.25636/PMP.1.2018.3.1"
            },
            {
                "key": "ref39",
                "doi": "10.2174/0929867053764635",
                "unstructured": "Metals, toxicity, and oxidative stress (38). Valko M., Morris H., Cronin M.T. Current medicinal chemistry, 2005, 12, 10, 1161–1208"
            },
            {
                "key": "ref40",
                "unstructured": "Domenyuk D.A., Davydov B.N., Vedeshina E.G., and Dmitrienko S.V. Investigating functional changes in the oral homeostasis system: Improving diagnostic approaches for dentoalveolar abnormalities (Part I). Publication: 2016; Volume: 71, Issue: 2; Pages: 74–77. (In Russian)"
            },
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                "key": "ref41",
                "unstructured": "Domenyuk, D.A., Davydov, B.N., Vedeshina, E.G., and Dmitrienko, S.V. (Part II): Improving dentoalveolar anomaly diagnostic approaches via the investigation of functional changes in the oral homeostasis system. (In Russ.) The Dental Institute. 2016; 72(3): 58-60. M Kishore Babu, T Pavani, D Divyasri, P Krupa Rani: Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A Multi Parametric Approach"
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                "key": "ref42",
                "unstructured": "Karslieva A.G., Domenyuk D.A., Zelensky V.A. Trace element composition in mixed saliva collected from children with dentoalveolar abnormalities after treatment with an apparatus. Volume 4, Issue 1 of Archiv EuroMedica, 2014, pages 29–35"
            },
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                "key": "ref43",
                "unstructured": "Diabetes Atlas, 7th Edition. International Diabetes Federation. 2015"
            },
            {
                "key": "ref44",
                "doi": "10.1111/pedi.12182",
                "unstructured": "Compendium of ISPAD Clinical Practice Consensus Guidelines, 2014. Research in Pediatric Diabetes. 2014; 15(Suppl. 20): 1-290"
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