{
    "ok": true,
    "doi": "10.46243/jst.2021.v6.i3.pp17-20",
    "doi_display": "10.46243/jst.2021.v6.i3.pp17-20",
    "doi_url": "https://doi.org/10.46243/jst.2021.v6.i3.pp17-20",
    "state": "registered",
    "url": "https://www.jst.org.in/index.php/pub/article/view/792",
    "title": "A Review of Investigational Treatments for Covid-19 - Zinc Supplementary",
    "version": 2,
    "registered_via": "crossref",
    "prefix": {
        "prefix": "10.46243",
        "status": "live"
    },
    "registrant": {
        "name": "Longman Publishers",
        "kind": "publisher",
        "country": "India"
    },
    "reserved_at": null,
    "registered_at": "2026-09-29 22:00:41",
    "updated_at": "2026-09-30 00:00:01",
    "withdrawn_at": null,
    "withdrawn_reason": null,
    "record": {
        "format": "smartscholars-doi-metadata/1.0",
        "doi": "10.46243/jst.2021.v6.i3.pp17-20",
        "referent": "Creation",
        "type": "JournalArticle",
        "structural_type": "Digital",
        "modes": [
            "Visual"
        ],
        "characters": [
            "Language"
        ],
        "titles": [
            {
                "value": "A Review of Investigational Treatments for Covid-19 - Zinc Supplementary",
                "type": "PrincipalTitle",
                "lang": "en"
            }
        ],
        "identifiers": [
            {
                "type": "DOI",
                "value": "10.46243/jst.2021.v6.i3.pp17-20"
            }
        ],
        "agents": [
            {
                "role": "author",
                "name": {
                    "given": "",
                    "family": "Dr. K. Deepa"
                },
                "sequence": "first"
            },
            {
                "role": "author",
                "name": {
                    "given": "Dr. Preethi",
                    "family": "Anand"
                },
                "sequence": "additional"
            },
            {
                "role": "author",
                "name": {
                    "given": "",
                    "family": "Dr. S. Kothai"
                },
                "sequence": "additional"
            },
            {
                "role": "publisher",
                "name": {
                    "org": "Longman Publishers"
                }
            }
        ],
        "dates": {
            "published": "2021-05-20",
            "date_type": "PublicationDate",
            "online": "2021-05-20"
        },
        "language": "en",
        "container": {
            "type": "Journal",
            "titles": [
                {
                    "value": "Journal of Science & Technology",
                    "type": "PrincipalTitle"
                }
            ],
            "identifiers": [
                {
                    "type": "ISSN",
                    "value": "2456-5660",
                    "medium": "electronic"
                }
            ],
            "volume": "06",
            "issue": "03",
            "pages": {
                "first": "17",
                "last": "20"
            }
        },
        "links": [
            {
                "url": "https://www.jst.org.in/index.php/pub/article/view/792",
                "return_type": "text/html",
                "primary": true
            },
            {
                "url": "https://www.jst.org.in/index.php/pub/article/download/792/724",
                "purpose": "text-mining",
                "return_type": "application/pdf"
            },
            {
                "url": "https://www.jst.org.in/index.php/pub/article/download/792/2429",
                "purpose": "text-mining",
                "return_type": "application/xml"
            },
            {
                "url": "https://www.jst.org.in/index.php/pub/article/view/792/724",
                "purpose": "similarity-checking"
            }
        ],
        "abstract": {
            "value": "Zinc (Zn) is an investigational agent against Coronavirus disease 2019 (COVID-19) and has known protective and medicinal function for other infections. Due to the quick increase and vast number of pretentious individuals worldwide, cost-effective, globally available, and safe options with minimal side effects and simple application are extremely warranted. Zn deficiency is associated with lower survival among older patients with pneumonia and predisposes to other viral infections. Zn supplement has an efficacious against COVID-19 and to improve normal immune cell function, in particular in elderly patients. Zinc may decrease the activity of the angiotensin converting enzyme 2, the receptor for SARS-CoV-2. Zinc T-cell modulation may down regulate the cytokine storm associated with severe COVID-19. Therefore, it may be suggested that Zn supplementation may be of potential support for treatment of COVID-19",
            "lang": "en"
        },
        "license": {
            "url": "https://creativecommons.org/licenses/by/4.0/",
            "start": "2021-05-20",
            "applies_to": "vor"
        },
        "references": [
            {
                "key": "ref1",
                "doi": "10.1016/j.mehy.2020.109848",
                "unstructured": "Kumar A, Kubota Y, Chernov M, Kasuya H. Potential role of zinc supplementation in prophylaxis and treatment of COVID-19. Medical Hypotheses. 2020; 144: 109848"
            },
            {
                "key": "ref2",
                "doi": "10.2807/1560-7917.es.2020.25.5.200131e",
                "unstructured": "World Health Organization. Updated WHO advice for international traffic in relation to the outbreak of the novel coronavirus 2019 nCoV. 2020. Available at: https://www.who.int/ith/2020 2401outbreakofpneumoniacausedbynewcoronavirus/en/. 2020"
            },
            {
                "key": "ref3",
                "unstructured": "Robert BS and Rebecca R. Zinc: An Essential Micronutrient. Am Fam Physician. 2009; 79(9): 768"
            },
            {
                "key": "ref4",
                "doi": "10.1038/nrd.2015.37",
                "unstructured": "Zumla A, Chan JF, Azhar EI et al. Coronaviruses—drug discovery and therapeutic options. Nat Rev Drug Discov. 2016; 15(5):327–347"
            },
            {
                "key": "ref5",
                "doi": "10.1002/ppul.20771",
                "unstructured": "Abdulhamid I, Beck FW, Millard S, Chen X, Prasad A. Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis. Pediatr Pulmonol. 2008; 43: 281–287"
            },
            {
                "key": "ref6",
                "doi": "10.1177/2054270417694291",
                "unstructured": "Hemila H, Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM Open. 2017; 8: 2054270417694291"
            },
            {
                "key": "ref7",
                "doi": "10.1128/aac.25.1.20",
                "unstructured": "Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother. 1984; 25: 20–24"
            },
            {
                "key": "ref8",
                "doi": "10.1101/2020.05.02.20080036",
                "unstructured": "Philip MC, Tania A, Christopher P, Harish R, Simon J, Joseph R. Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients. Journal of Medical Microbiology. 2020"
            },
            {
                "key": "ref9",
                "doi": "10.1002/jmv.25707",
                "unstructured": "Zhang L and Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol. 2020; 92: 479-490"
            },
            {
                "key": "ref10",
                "doi": "10.2174/1874306401105010051",
                "unstructured": "Hemila H. Zinc lozenges may shorten the duration of colds: a systematic review. Open Respir Med J 2011; 5: 51–58"
            },
            {
                "key": "ref11",
                "doi": "10.3892/ijmm.2020.4575",
                "unstructured": "SKALNY et al. Zinc and respiratory tract infections: Perspectives for COVID-19 (Review). International Journal of Molecular Medicine. 2020"
            },
            {
                "key": "ref12",
                "doi": "10.3389/fimmu.2020.01712",
                "unstructured": "Inga W, Benjamin R and Lothar R. The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis Frontiers in Immunology. www.frontiersin.org. 2020; 11: 1712"
            },
            {
                "key": "ref13",
                "doi": "10.1016/j.mehy.2020.109848",
                "unstructured": "Amit K, Yuichi K, Mikhail C, Hidetoshi K. Potential role of zinc supplementation in prophylaxis and treatment of COVID-19. Medical Hypotheses. 2020; 144: 109848"
            },
            {
                "key": "ref14",
                "unstructured": "Ademola Adetokunbo Oyagbemi., et.al., Potential health benefits of zinc supplementation for the management of COVID ‐19 pandemic. J Food Biochem. 2021; 00: 13604"
            },
            {
                "key": "ref15",
                "doi": "10.1186/s12875-015-0237-6",
                "unstructured": "Hemila H and Chalker E. The effectiveness of high dose zinc acetate lozenges on various common cold symptoms: a meta-analysis. BMC Family Practice. 2015. 16: 24"
            },
            {
                "key": "ref16",
                "doi": "10.1016/s0011-393x(98)85058-3",
                "unstructured": "Petrus EJ, Lawson KA, Bucci LR, et al. Randomized, double-masked, placebo-controlled clinical study of the effec tiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects. Current therapeutic research, 1998; 59"
            },
            {
                "key": "ref17",
                "doi": "10.1099/jmm.0.001250",
                "unstructured": "SHORT COMMUNICATION Carlucci et al. Zinc sulfate in combination with a Zinc ionophore may improve outcomes in hospitalized COVID-19 patients. Journal of Medical Microbiology. 2020; 69:1228–1234"
            },
            {
                "key": "ref18",
                "doi": "10.1023/b:bire.0000037754.71063.41",
                "unstructured": "Eby GA. Zinc lozenges: cold cure or candy? Solution chemistry determinations. Biosci Rep. 2004; 24: 23–39"
            },
            {
                "key": "ref19",
                "doi": "10.1016/j.mehy.2009.10.017",
                "unstructured": "Eby GA. Zinc lozenges as cure for the common cold–a review and hypothesis. Med Hypotheses. 2010; 74: 482–492"
            },
            {
                "key": "ref20",
                "doi": "10.1093/jac/20.6.893",
                "unstructured": "Al-Nakib W, Higgins PG, Barrow I, et al. Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. J Antimicrob A Review of Investigational Treatments for Covid-19-Zinc Supplementary 20 | Page Chemother. 1987; 20: 893–901"
            },
            {
                "key": "ref21",
                "doi": "10.1177/026988119100500312",
                "unstructured": "Smith AP, Tyrrell DA, Al-Nakib W, et al. Effects of zinc gluconate and nedocromil sodium on performance deficits produced by the common cold. J Psychopharmacol 1991; 5: 251–254"
            },
            {
                "key": "ref22",
                "doi": "10.1177/030006059202000305",
                "unstructured": "Godfrey JC, Sloane BC, Smith DS, et al. Zinc gluconate and the common cold: a controlled clinical study. J Int Med Res. 1992; 20: 234–246"
            },
            {
                "key": "ref23",
                "doi": "10.7326/0003-4819-125-2-199607150-00001",
                "unstructured": "Mossad SB, Macknin ML, Medendorp SV, et al. Zinc gluconate lozenges for treating the common cold. A randomized, double-blind, placebo-controlled study. Ann Intern Med. 1996; 125: 81–88"
            },
            {
                "key": "ref24",
                "doi": "10.1128/aac.25.1.20",
                "unstructured": "Eby GA, Davis DR and Halcomb WW. Reduction in duration of common cold by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother. 1984; 25: 20–24"
            },
            {
                "key": "ref25",
                "doi": "10.1371/journal.pone.0109180",
                "unstructured": "Xue J, Moyer A, Peng B, Wu J, Hannafon BN et al. Chloroquine is a Zinc ionophore. PLoS One. 2014; 9"
            }
        ],
        "record": {
            "registrant": "Longman Publishers",
            "registered": "2026-09-12",
            "updated": "2026-09-20",
            "issue_number": 1,
            "source": "crossref-api",
            "source_agency": "Crossref (member 25296)"
        }
    },
    "record_sha256": "4835220c4b03711abc470b64915810b892e0eb57b0e848aac7147e9231adac7b",
    "handle": {
        "synced_at": "2026-10-01 18:13:55",
        "url": "https://www.jst.org.in/index.php/pub/article/view/792"
    },
    "links": {
        "record_page": "https://registry.smartscholars.in/record.php?doi=10.46243%2Fjst.2021.v6.i3.pp17-20",
        "system_metadata": "https://registry.smartscholars.in/resolve.php?doi=10.46243%2Fjst.2021.v6.i3.pp17-20&as=system",
        "history": "https://registry.smartscholars.in/api.php?action=history&doi=10.46243%2Fjst.2021.v6.i3.pp17-20",
        "kernel_xml": "https://registry.smartscholars.in/resolve.php?doi=10.46243%2Fjst.2021.v6.i3.pp17-20&as=xml"
    }
}