Cite this DOI
10.46243/jst.2021.v6.i04.pp283-291 · Metformin hydrochloride-loaded biodegradable microspheres employing the Box Behnken design for local delivery in periodontitis: design, optimization, and characterization
APA (7th edition)
mathur, A., prasad, S., & Aktar, N. (2021). Metformin hydrochloride-loaded biodegradable microspheres employing the Box Behnken design for local delivery in periodontitis: design, optimization, and characterization. *Journal of Science & Technology*, *06*(04), 283–291. https://doi.org/10.46243/jst.2021.v6.i04.pp283-291
⬇ text Italics are shown as *asterisks* in plain text — the journal or book title and the volume.
BibTeX
@article{mathur2021metformin,
author = {mathur, Adithya and prasad, Shiva and Aktar, Nasim},
title = {{Metformin hydrochloride-loaded biodegradable microspheres employing the Box Behnken design for local delivery in periodontitis: design, optimization, and characterization}},
journal = {Journal of Science \& Technology},
year = {2021},
month = {jul},
volume = {06},
number = {04},
pages = {283--291},
publisher = {Longman Publishers},
issn = {2456-5660},
doi = {10.46243/jst.2021.v6.i04.pp283-291},
url = {https://doi.org/10.46243/jst.2021.v6.i04.pp283-291},
language = {en},
abstract = {In the current research, periodontitis was treated by filling periodontal pockets with metformin hydrochlorideloaded microspheres, either with or without grafts. In order to do this, chitosan was selected as the polymer and used in various drug/polymer ratios during the emulsion cross-linking process to create microspheres. Utilizing a three-factor, three-level Box–Behnken architecture allowed for optimization. Regression analysis was used to create mathematical models for the responses of particle size (PS) and entrapment efficiency (EE). The experimental design considered the economical reduction of chemical usage and formulation time to develop an optimized formulation with highest \%EE and minimal PS under optimal process conditions for the microsphere formulation. Based on the desirability function, the optimal formulation was chosen, and it was then assessed in terms of particle size, entrapment efficiency, drug release in vitro, differential scanning calorimetry (DSC), fourier transform infrared (FTIR) spectroscopy, and surface morphology investigations. Kinetic and statistical analyses were performed on the release study findings. The chosen batch's particle size and entrapment effectiveness were determined to be between 40.2 and 59.6 μm and 85 and 95\%, respectively. The drug's molecular dispersion and transformation into an amorphous state were shown by the DSC investigations. By using scanning electron microscopy (SEM) to examine the surface morphology of the microspheres, it was discovered that they had a smooth, spherical surface}
}RIS (EndNote, Zotero, Mendeley)
TY - JOUR TI - Metformin hydrochloride-loaded biodegradable microspheres employing the Box Behnken design for local delivery in periodontitis: design, optimization, and characterization AU - mathur, Adithya AU - prasad, Shiva AU - Aktar, Nasim JO - Journal of Science & Technology PY - 2021 DA - 2021/07/27/ VL - 06 IS - 04 SP - 283 EP - 291 PB - Longman Publishers SN - 2456-5660 LA - en AB - In the current research, periodontitis was treated by filling periodontal pockets with metformin hydrochlorideloaded microspheres, either with or without grafts. In order to do this, chitosan was selected as the polymer and used in various drug/polymer ratios during the emulsion cross-linking process to create microspheres. Utilizing a three-factor, three-level Box–Behnken architecture allowed for optimization. Regression analysis was used to create mathematical models for the responses of particle size (PS) and entrapment efficiency (EE). The experimental design considered the economical reduction of chemical usage and formulation time to develop an optimized formulation with highest %EE and minimal PS under optimal process conditions for the microsphere formulation. Based on the desirability function, the optimal formulation was chosen, and it was then assessed in terms of particle size, entrapment efficiency, drug release in vitro, differential scanning calorimetry (DSC), fourier transform infrared (FTIR) spectroscopy, and surface morphology investigations. Kinetic and statistical analyses were performed on the release study findings. The chosen batch's particle size and entrapment effectiveness were determined to be between 40.2 and 59.6 μm and 85 and 95%, respectively. The drug's molecular dispersion and transformation into an amorphous state were shown by the DSC investigations. By using scanning electron microscopy (SEM) to examine the surface morphology of the microspheres, it was discovered that they had a smooth, spherical surface DO - 10.46243/jst.2021.v6.i04.pp283-291 UR - https://doi.org/10.46243/jst.2021.v6.i04.pp283-291 ER -
CSL-JSON
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From the record as registered (version 2) — the record and its history. Programs: https://registry.smartscholars.in/api.php?action=cite&doi=10.46243%2Fjst.2021.v6.i04.pp283-291 gives all four in one JSON answer.
