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Pyridine and pyrazole activities can be augmented through the formation of heterocyclic compounds. In this study, we synthesized and evaluated novel heterocyclic compounds containing pyridine and pyrazole. The phys-iochemical characteristics revealed the structural properties of the synthesized compounds. The compounds were evaluated for their antibacterial and antifungal activities, which showed significant antimicrobial proper-ties. The antioxidant activities analyzed by DPPH free radical scavenging activity that showed concentration dependent scavenging activities of the synthesized pyridine and pyrazole compounds. 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F.El-Farargy and S.Abdelaziz, Synthesis and Antimicrobial Activities of New S-Nucleosides of Chromeno[2,3-B] Pyridine Derivatives and C-Nucleosides of [1,2,4]Triazolo[1,5-a]Quinoline Derivatives, Nucleosides Nucleotides & Nucleic Acids, 33(9), 2014, 583-596" }, { "key": "ref11", "doi": "10.1021/cr020033s", "unstructured": "D. A.Horton, G. T.Bourne and M. L.Smythe, The combinatorial synthesis of bicyclic privileged structures or privileged substructures, Chemical Reviews, 103(3), 2003, 893-930" }, { "key": "ref12", "doi": "10.1128/aac.34.5.858", "unstructured": "G. A.Jacoby and I.Carreras, Activities of Beta-Lactam Antibiotics against Escherichia-Coli Strains Producing Extended-Spectrum Beta-Lactamases, Antimicrobial Agents and Chemotherapy, 34(5), 1990, 858-862" }, { "key": "ref13", "doi": "10.1016/s0378-8741(03)00006-0", "unstructured": "I.Karaman,, F.Sahin, M.Gulluce, H.Ogutcu, M.Sengul and A.Adiguzel, Antimicrobial activity of aqueous and methanol extracts of Juniperus oxycedrus L, J Ethnopharmacol, 85(2-3), 2003, 231-235" }, { "key": "ref14", "doi": "10.3390/molecules23010134", "unstructured": "K.Karrouchi, S.Radi, Y.Ramli, J.Taoufik, Y. N.Mabkhot, F. A.Al-aizari and M.Ansar, Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review, Molecules, 23(1), 2018" }, { "key": "ref15", "doi": "10.1016/j.ejmech.2016.04.077", "unstructured": "M. F.Khan, M. M.Alam, G.Verma,W.Akhtar, M.Akhter and M.Shaquiquzzaman, The therapeutic voyage of pyrazole and its analogs: A review, European Journal of Medicinal Chemistry, 120, 2016, 170-201" }, { "key": "ref16", "doi": "10.1135/cccc19990417", "unstructured": "V.Klimesova, M.Svoboda, K.Waisser, M.Pour and J.Kaustova, Synthesis and antimicrobial activity of new 4-(benzylsulfanyl)pyridine derivatives, Collection of Czechoslovak Chemical Communications, 64(2), 1990, 417-434" }, { "key": "ref17", "doi": "10.1248/cpb.c12-01016", "unstructured": "D. R.Martins, F.Pazini, V. D. Alves, S. S.de Moura, L. M.Liao, M. T. Q.de Magalhaes and M. L.Rocha, Synthesis, Docking Studies, Pharmacological Activity and Toxicity of a Novel Pyrazole Derivative (LQFM 021)-Possible Effects on Phosphodiesterase, Chemical & Pharmaceutical Bulletin, 61(5), 2013, 524-531" }, { "key": "ref18", "doi": "10.1093/clinids/14.6.1173", "unstructured": "R. C.Moellering, Emergence of Enterococcus as a Significant Pathogen, Clinical Infectious Diseases, 14(6), 1992, 1173-1176" }, { "key": "ref19", "doi": "10.1002/ptr.1016", "unstructured": "P. K.Mukherjee, G. S.Saritha and B.Suresh, Antimicrobial potential of two different Hypericum species available in India, Phytother Res, 16(7), 2002, 692-695" }, { "key": "ref20", "doi": "10.3998/ark.5550190.0010.e06", "unstructured": "D. C.Mungra, M. P.Patel and R. G.Patel, An efficient one-pot synthesis and in vitro antimicrobial activity of new pyridine derivatives bearing the tetrazoloquinoline nucleus, Arkivoc, 2009, 64-74" }, { "key": "ref21", "doi": "10.1007/s00044-010-9440-0", "unstructured": "N. B.Patel, S. N.Agravat and F. M. Shaikh, Synthesis and antimicrobial activity of new pyridine derivatives-I, Medicinal Chemistry Research, 20(7), 2011, 1033-1041" }, { "key": "ref22", "doi": "10.1016/j.bmcl.2006.10.039", "unstructured": "G.Puerstinger, J.Paeshuyse, E.De Clercq and J.Neyts, Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to antihepatitis C virus activity, Bioorg Med Chem Lett, 17(2), 2007, 390-393" }, { "key": "ref23", "doi": "10.1177/1082013202008003770", "unstructured": "C. Sanchez-Moreno, Review: Methods used to evaluate the free radical scavenging activity in foods and biological systems, Food Science and Technology International, 8(3), 2002, 121-137" }, { "key": "ref24", "doi": "10.1016/j.bmcl.2005.02.039", "unstructured": "C.Selvam, S. M. Jachak, R.Thilagavathi and A. K. Chakraborti, Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 15(7), 2005, 1793-1797" }, { "key": "ref25", "doi": "10.56042/ijc.v63i11.13199", "unstructured": "S. C.Shetty and V. C. Bhagat, Synthesis and pharmacological activities of 3-(4-substituted phenyl)-1-phenyl-1H-pyrazole-4carboxaldehyde and its aldimines derivatives, Asian Journal of Chemistry, 20(7), 2008, 5037-5045" } ], "record": { "registrant": "Longman Publishers", "registered": "2026-09-08", "updated": "2026-09-20", "issue_number": 1, "source": "crossref-api", "source_agency": "Crossref (member 25296)" } }, "url_after": "https://www.jst.org.in/index.php/pub/article/view/223", "sha256_before": null, "sha256_after": "9831654258fdc293c33e78359a1adcc83adf5deec1ab11d85a04ec03448c49e6" }, { "seq": 2, "kind": "update", "at": "2026-09-29 23:59:57", "by": "Administrator (admin)", "by_kind": "user", "note": "record re-read from api.crossref.org", "changes": [ { "path": "container.titles.0.value", "from": "Journal of Science & Technology", "to": "Journal of Science & Technology" } ], "record_after": { "format": "smartscholars-doi-metadata/1.0", "doi": "10.46243/jstj.2020.v5.i1.223", "referent": "Creation", "type": "JournalArticle", "structural_type": "Digital", "modes": [ "Visual" ], "characters": [ "Language" ], "titles": [ { "value": "Synthesis and Characterization of Pyridine and Pyrazole Deriva-tives for Their Biological Activities", "type": "PrincipalTitle", "lang": "en" } ], "identifiers": [ { "type": "DOI", "value": "10.46243/jstj.2020.v5.i1.223" } ], "agents": [ { "role": "author", "name": { "given": "M. Rama", "family": "Vidhya" }, "sequence": "first" }, { "role": "author", "name": { "given": "Dr.S. Jasmin", "family": "Sugantha Malar" }, "sequence": "additional" }, { "role": "publisher", "name": { "org": "Longman Publishers" } } ], "dates": { "published": "2020-01-01", "date_type": "PublicationDate", "online": "2020-01-01" }, "language": "en", "container": { "type": "Journal", "titles": [ { "value": "Journal of Science & Technology", "type": "PrincipalTitle" } ], "identifiers": [ { "type": "ISSN", "value": "2456-5660", "medium": "electronic" } ], "volume": "05", "issue": "01", "pages": { "first": "01", "last": "08" } }, "links": [ { "url": "https://www.jst.org.in/index.php/pub/article/view/223", "return_type": "text/html", "primary": true }, { "url": "https://www.jst.org.in/index.php/pub/article/download/223/200", "purpose": "text-mining", "return_type": "application/pdf" }, { "url": "https://www.jst.org.in/index.php/pub/article/download/223/2972", "purpose": "text-mining", "return_type": "application/xml" }, { "url": "https://www.jst.org.in/index.php/pub/article/view/223/200", "purpose": "similarity-checking" } ], "abstract": { "value": "Natural cyclic compounds have attracted more attention for several pharmacological applications. Pyridine and pyrazole activities can be augmented through the formation of heterocyclic compounds. In this study, we synthesized and evaluated novel heterocyclic compounds containing pyridine and pyrazole. The phys-iochemical characteristics revealed the structural properties of the synthesized compounds. The compounds were evaluated for their antibacterial and antifungal activities, which showed significant antimicrobial proper-ties. The antioxidant activities analyzed by DPPH free radical scavenging activity that showed concentration dependent scavenging activities of the synthesized pyridine and pyrazole compounds. These results revealed that the synthesized compounds could be further evaluated for preparing lead antimicrobial and antioxidant phar-maceutical agent.", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2020-01-01", "applies_to": "vor" }, "references": [ { "key": "ref1", "doi": "10.2174/1570180811666140512220842", "unstructured": "F.Abrigach, M.Khoutoul, N.Benchat,S. Radi,N. Draoui,O. Feron,O. Riant and R.Touzani, Library of Synthetic Compounds Based on Pyrazole Unit: Design and Screening Against Breast and Colorectal Cancer, Letters in Drug Design & Discovery, 11(8), 2014, 1010- 1016" }, { "key": "ref2", "doi": "10.1016/0732-8893(90)90037-v", "unstructured": "K. E.Aldridge, M. S.Gelfand, D. D.Schiro and N. 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M.Alam, G.Verma,W.Akhtar, M.Akhter and M.Shaquiquzzaman, The therapeutic voyage of pyrazole and its analogs: A review, European Journal of Medicinal Chemistry, 120, 2016, 170-201" }, { "key": "ref16", "doi": "10.1135/cccc19990417", "unstructured": "V.Klimesova, M.Svoboda, K.Waisser, M.Pour and J.Kaustova, Synthesis and antimicrobial activity of new 4-(benzylsulfanyl)pyridine derivatives, Collection of Czechoslovak Chemical Communications, 64(2), 1990, 417-434" }, { "key": "ref17", "doi": "10.1248/cpb.c12-01016", "unstructured": "D. R.Martins, F.Pazini, V. D. Alves, S. S.de Moura, L. M.Liao, M. T. Q.de Magalhaes and M. L.Rocha, Synthesis, Docking Studies, Pharmacological Activity and Toxicity of a Novel Pyrazole Derivative (LQFM 021)-Possible Effects on Phosphodiesterase, Chemical & Pharmaceutical Bulletin, 61(5), 2013, 524-531" }, { "key": "ref18", "doi": "10.1093/clinids/14.6.1173", "unstructured": "R. C.Moellering, Emergence of Enterococcus as a Significant Pathogen, Clinical Infectious Diseases, 14(6), 1992, 1173-1176" }, { "key": "ref19", "doi": "10.1002/ptr.1016", "unstructured": "P. K.Mukherjee, G. S.Saritha and B.Suresh, Antimicrobial potential of two different Hypericum species available in India, Phytother Res, 16(7), 2002, 692-695" }, { "key": "ref20", "doi": "10.3998/ark.5550190.0010.e06", "unstructured": "D. C.Mungra, M. P.Patel and R. G.Patel, An efficient one-pot synthesis and in vitro antimicrobial activity of new pyridine derivatives bearing the tetrazoloquinoline nucleus, Arkivoc, 2009, 64-74" }, { "key": "ref21", "doi": "10.1007/s00044-010-9440-0", "unstructured": "N. B.Patel, S. N.Agravat and F. M. 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