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                        "url": "https://www.jst.org.in/index.php/pub/article/download/149/129",
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                "abstract": {
                    "value": "A validate rapid, economical and sensitive visible spectrophotometric method has been developed for quantitative determination of bendamustine hydrochloride in bulk drug and formulation sampleswith no interference from the excipients or solvents of injectable solution. This method is validated for irinotecan with chromogenic reagent 2,2’-bipyridyl.The calibration curve is linear over a concentration range from 2-12μg/ml.The relative standard deviation (R.S.D) is less than 1% and average recovery is above 100.00 %.The proposed method is fast, sensitive, precise, accurate and efficient and can be used for analysis in quality control laboratories.",
                    "lang": "en"
                },
                "license": {
                    "url": "https://creativecommons.org/licenses/by/4.0/",
                    "start": "2018-01-01",
                    "applies_to": "vor"
                },
                "references": [
                    {
                        "key": "ref1",
                        "unstructured": "TREANDA® (bendamustine hydrochloride) for Injection, for intravenous infusion Initial U.S. Approval: 2008"
                    },
                    {
                        "key": "ref2",
                        "doi": "10.1111/j.1349-7006.2010.01633.x",
                        "unstructured": "MichinoriOgura,ToshikiUchida,MasafumiTaniwaki,Kiyoshi Ando, Takashi, Watanabe, Masanobu Kasai, Yosuke Matsumoto,DaisukeShimizu,YoshiakiOgawa,KenOhmachi,HirokiYokoyama,KenseiTobinai,,Phase I and pharmacokinetic study of bendamustine hydrochloride in relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma,Cancer Science,27 May 2010"
                    },
                    {
                        "key": "ref3",
                        "doi": "10.1038/sj.bjc.6603776",
                        "unstructured": "M Rasschaert1,5, D Schrijvers2, J Van den Brande1, J Dyck1, J Bosmans3, K Merkle4 and J B Vermorken1,A phase I study of bendamustine hydrochloride administered day 1+2 every 3 weeks in patients with solid tumours, British Journal of Cancer (2007), Received 25 January 2007; Revised 12 April 2007; Accepted 12 April 2007"
                    },
                    {
                        "key": "ref4",
                        "unstructured": "PavaniPeddi*, T. Raja Rajeswari,andRamana Reddy Ganji, Development and validation of stability indicating HPLC method for estimation of related substances in bendamustinehydrochloride,scholars research library,2016"
                    },
                    {
                        "key": "ref5",
                        "doi": "10.23880/oajpr-16000158",
                        "unstructured": "E. Sasi Kiran Goud* and V. Krishna Reddy, Development and validation of RP-HPLC method for determination of relatedsubstances of bendamustine hydrochloride in bulk drug,Pelegia Research Library,2013"
                    },
                    {
                        "key": "ref6",
                        "doi": "10.1093/chromsci/bmw145",
                        "unstructured": "Yuvraj Singh AnumandlaChandrashekarVivek K. PawarVeeramuthuSaravanakumarJayagopalMeherKavitRaval Pankaj Singh R. Dinesh Kumar Manish K. Chourasia,Novel Validated RP-HPLC Method for Bendamustine Hydrochloride Based on Ion-pair Chromatography: Application in Determining Infusion Stability and Pharmacokinetics J ChromatogrSci (2017)"
                    },
                    {
                        "key": "ref7",
                        "doi": "10.1016/j.jchromb.2012.02.039",
                        "unstructured": "Dubbelman AC1, Tibben M, Rosing H, Gebretensae A, Nan L, Gorman SH, Robertson P Jr, Schellens JH, BeijnenJH,Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine,Epub,2012 march"
                    },
                    {
                        "key": "ref8",
                        "doi": "10.1093/chromsci/bmt075",
                        "unstructured": "SrinivasuluKasa M Raja Sekhar Reddy Raja SekharKadaboinaVeerenderMurkiVenkataSuryanarayanaMulukutla,Stability-Indicating LC Method for the Estimation of Bendamustine Hydrochloride and its Related Impurities, J ChromatogrSci (2014)"
                    },
                    {
                        "key": "ref9",
                        "doi": "10.7324/japs.2012.21126",
                        "unstructured": "Annapurna, M. Mathrusri; Anusha, S.; Pavani, S.; Mahanti, Harika,New Spectrophotometric Methods for the Determination of Bendamustine Hydrochloride-Nitrogen Mustard, Drug Invention Today,Oct2012, Vol. 4 Issue 10, p487-490. 4p"
                    },
                    {
                        "key": "ref10",
                        "doi": "10.7324/japs.2012.21126",
                        "unstructured": "M. Mathrusri Annapurna*, S. Pavani, S. Anusha, HarikaMahanti and B. Venkatesh,New analytical methods for the determination of Bendamustine hydrochloride: An anti-neoplastic drug,Journal of Chemical and Pharmaceutical Research, 2012, 4(3):1696-1701"
                    }
                ],
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                    "updated": "2026-09-28",
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