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This method is successfully applied to the efficient synthesis of mono-and disubstituted pyrimidine derivatives, using methyl ketone derivatives by using biodegradable,ecofriendly polychem@36 as solvent in ultrasound condition at 800C giving good yieldupto 80-90% .The reaction is completed in short period of time i.e. 1-3 hrs as compared to other reaction.", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2024-04-08", "applies_to": "vor" }, "references": [ { "key": "ref1", "doi": "10.1016/j.bmcl.2006.01.111", "unstructured": "Waterson, A. G.; Stevens, K. L.; Reno, M. J.; Zhang,. Med. Chem. Lett. 2006, 16, 2419" }, { "key": "ref2", "unstructured": "Dickinson, R. P.; Bell, A. S.; Hitchcock, C. A.; Narayanaswami, S.; Ray, S. J.; Richardson, K.; Troke, P. F. Bioorg. Med. Chem. Lett. 1996, 6, 2031" }, { "key": "ref3", "doi": "10.1021/jo971368q", "unstructured": "Brodfuehrer, P. R.; Chen, B.-C.; Sattelberg, T. R., Sr.; Smith, P. R.; Reddy, J. 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