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                        "doi": "10.3390/plants13030360",
                        "unstructured": "Núñez MJ, Martínez ML, Castillo UG, Flores KC, Menjívar J, López-Arencibia A, Bethencourt-Estrella CJ, Jiménez IA, Piñero JE, Lorenzo-Morales J and Bazzocchi IL: Salvadoran Celastraceae species as a source of antikinetoplastid quinonemethide triterpenoids. Plants 2024; 13(3): 360"
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                        "unstructured": "MINSAL M de S de ESD de E. Casos sospechosos of Chagas agudo y crónico [Internet]. [place unknown]"
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                        "key": "ref4",
                        "doi": "10.1002/vms3.912",
                        "unstructured": "Nekoei S, Khamesipour F, Habtemariam S, de Souza W, Pour PM and Hosseini SR: The anti-Trypanosoma activities of medicinal plants: A systematic review of the literature. Veterinary Medicine and Science 2022; 8: 2738–2772"
                    },
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                        "key": "ref5",
                        "doi": "10.1007/s11418-021-01562-6",
                        "unstructured": "CastilloUG, KomatsuA, MartínezML, MenjívarJ, Núñez MJ, Uekusa Y, Narukawa Y, Kiuchi F and Nakajima-Shimada J: Anti-trypanosomal screening of Salvadoran flora. Journal Natural Medicine 2022; 76: 259–267"
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                        "key": "ref6",
                        "doi": "10.1021/acs.jnatprod.4c00022",
                        "unstructured": "Castillo UG, Uekusa Y, Nishimura T, Kiuchi F, Martínez ML, Menjívar J, Nakajima-Shimada J, Núñez MJ and Kikuchi H: Anti-trypanosomal lignans isolated from Salvadoran Peperomia pseudopereskiifolia. Journal of Natural Products 2024; 87: 1067–1074"
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                        "key": "ref7",
                        "doi": "10.1016/j.jics.2021.100231",
                        "unstructured": "Amala AR and Joseph SM: Anticancer potential ofAnnona genus: A detailed review. Journal of the Indian ChemicalSociety2021;98(12):100231"
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                        "unstructured": "Moussa AY, Siddiqui SA, Elhawary EA, Guo K, Anwar S and Xu B: Phytochemical constituents, bioactivities and applications of custard apple (Annona squamosa L.): A narrativereview. FoodChemistry2024;459:140363"
                    },
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                        "key": "ref9",
                        "doi": "10.3390/molecules27113462",
                        "unstructured": "Al Kazman BS, Harnett M and Hanrahan JR: Traditional uses, phytochemistry and pharmacological activities of Annonacae. Molecules 2022; 27(11): 3462"
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                        "key": "ref10",
                        "doi": "10.3390/plants12020322",
                        "unstructured": "Soto-Vásquez MR, Alvarado-García PA, Osorio EH, Tallini LR and Bastida J: Antileishmanial activity of Clinanthus milagroanthus S. Leiva & Meerow (Amaryllidaceae)collectedinPeru. Plants2023;12(2):322"
                    },
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                        "key": "ref11",
                        "unstructured": "Delgado-ParedesGE, Delgado-RojasPRandRojas-Idrogo C: Potential of the flora of Peruemphasizingin the Asteraceae family against Trypanosomacruzi. Revista Cubana de Medicina Tropical 2024;76"
                    },
                    {
                        "key": "ref12",
                        "doi": "10.1016/j.cbi.2021.109390",
                        "unstructured": "Rocha GN da SAO, Dutra LM, Lorenzo VP and DOI:https://doi.org/10.46243/jst.2024.v9.i02.pp01-1076 M. Vamshi Krishna, I. Devi, M. Sravya, Ch. Ajay Babu: Neuroprotective Potential of a Polyherbal Formulation in Enhancing Mental Clarity and Emotional Stability Almeida JRG da S: Phytochemicals and biological properties of Annona coriacea Mart. (Annonaceae): A systematicreviewfrom1971to2020.Chemico-Biological Interactions 2021; 336: 109390"
                    },
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                        "key": "ref13",
                        "doi": "10.1002/vms3.912",
                        "unstructured": "ShahinNekoe, F, KhamesipourF,HabtemariamS,deSW, Mohammadi Pour P and Hossein SR: The anti-trypanosoma activities of medicinal plants: A systematic review of the literature. Veterinary Medicine and Science 2022; 8(6): 2738–2772"
                    },
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                        "key": "ref14",
                        "doi": "10.1016/j.phytochem.2018.10.022",
                        "unstructured": "Gogineni V, Nael MA, León F, Núñez MJ and Cutler SJ: Computationally aidedstereochemical assignmentof undescribed bisabolenes from Calea urticifolia. Phytochemistry 2019; 157:145–"
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                        "key": "ref15",
                        "doi": "10.1016/j.phyplu.2022.100377",
                        "unstructured": "KamarajC, RagavendranC, KumarRCS,AliA, KhanSU, Mashwani Z ur-R, Luna-Arias JP and Pedroza JPR: Antiparasitic potential of Asteraceae plants: A comprehensive review on therapeutic and mechanistic aspects for biocompatible drug discovery. Phytomedicine Plus2022; 2(4):100377"
                    },
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                        "key": "ref16",
                        "doi": "10.1021/acs.jnatprod.6b00440",
                        "unstructured": "Chaurasiya ND, Gogineni V, Elokely KM, León F, Núñez MJ, Klein ML, Walker LA, Cutler SJ and Tekwani BL: Isolation of acacetin from Calea urticifolia with inhibitory properties against Human Monoamine Oxidase-A and-B. Journal of Natural Products 2016; 79:2538–2544"
                    },
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                        "key": "ref17",
                        "doi": "10.5897/jmpr2017.6412",
                        "unstructured": "Amaral P, Costa FV, Antunes AR, Kautz J, Citadini-ZanetteV, DévéhatFLL, BarlowJand DalBóS:Thegenus Calea L.: A review of isolated compounds and biological activities. Journal of Medical Plants Research 2017; 11:518–537"
                    },
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                        "key": "ref18",
                        "doi": "10.1016/j.bjp.2018.01.010",
                        "unstructured": "Mijangos-Ramos IF, Zapata-Estrella HE, Ruiz-Vargas JA, Escalante-Erosa F, Gómez-Ojeda N, García-Sosa K, Cechinel-Filho V, Meira-Quintão NL and Peña-Rodríguez LM: Bioactive dicaffeoylquinic acid derivatives from the root extract of Calea urticifolia. Revista Brasileira de Farmacognosia 2018; 28:339–343"
                    },
                    {
                        "key": "ref19",
                        "doi": "10.1002/ptr.6010",
                        "unstructured": "Cardoso T, Souza R de J, da Silva FA and Biavatti MW: The genus Calea L.: A review on traditional uses, phytochemistry, and biological activities. Phytotherapy Research 2018; 32: 769–795"
                    },
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                        "key": "ref20",
                        "doi": "10.21577/0100-4042.20170728",
                        "unstructured": "Lima TC, Souza RJ, Moraes MH, Matos SS, Almeida FHO, Steindel M and Biavatti MW: Isolation and characterization of sesquiterpenela ctonesfromCalea uniflora Less. and their leishmanicidal and trypanocidal activities. Química Nova 2021; 44(6): 696–699"
                    },
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                        "key": "ref21",
                        "doi": "10.14715/cmb/2022.68.10.19",
                        "unstructured": "Naik N, Kaushal RS, Upadhyay TK, Kahrizi D, Al-Najjar MA, Khan MS and Siddiqui S: Role of natural plant extracts for potential antileishmanial targets-In-depth review of the molecular mechanism. Cellular and Molecular Biology 2022; 68(10): 117–123"
                    },
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                        "key": "ref22",
                        "doi": "10.21577/0100-4042.20170728",
                        "unstructured": "Lima TC, Souza RJ, Morales MH, Matos SS, Almeida FHO, Steindel M and Biavatti MW: Isolation and characterization of sesquiterpene lactones from Calea uniflora less. and their leishmanicidal and trypanocidal activities. Quimica Nova 2021; 44(6): 696–699"
                    },
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                        "key": "ref23",
                        "doi": "10.52403/ijrr.20231138",
                        "unstructured": "Babu NJ, Ambika K and Rao GN: Genus Vernonia Mini Review. International Journal of Research and Review 2023; 10(11): 325–327"
                    },
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                        "key": "ref24",
                        "doi": "10.2174/2212798412666230330164954",
                        "unstructured": "Mishra N, Gupta E, Singh P, Soni S and Noor U: Insighton Vernonia plant for its pharmacological properties: A review. Recent Advances in Food Nutrition & Agriculture 2023; 14(2): 84–93"
                    },
                    {
                        "key": "ref25",
                        "doi": "10.3389/fphar.2019.00477",
                        "unstructured": "Moraes Neto RN, Setúbal RFB, Higino TMM, Brelaz-de-CastroMCA, Nascimentoda SilvaLC and AliançaASDS: Asteraceae plants as sources of compounds against Leishmaniasis and Chagas disease. Frontiers in Pharmacology 2019; 10:477"
                    },
                    {
                        "key": "ref26",
                        "doi": "10.1007/s00436-021-07199-4",
                        "unstructured": "Peixoto JF, Ramos YJ, de Lima Moreira D, Alves CR and Folcalves-Oliveira LF: Potential of Piper spp. as a source of new compounds for the leishmaniases treatment. Parasitology Research 2021; 120: 2731–2747"
                    },
                    {
                        "key": "ref27",
                        "doi": "10.21608/aprh.2024.225955.1230",
                        "unstructured": "Mbadiko C, Bongo G, Ngbolua KTN, Ngombe N, Kapepula P, Yandju MC, Mpiana P and Mbemba T: Uses, phytochemistry and biological activity of Piper genus: A review. Journal of Medicinal Herbs 2023; 14(1): 1–17"
                    },
                    {
                        "key": "ref28",
                        "doi": "10.37360/blacpma.22.21.1.02",
                        "unstructured": "Mesa-Vanegas AM, Naranjo-Gómez EJ, Cardona F, Atehortúa-Garcés L and Blair-Trujillo S: Quantitative standardization of pharmacologically active components from antiplasmodial plant Solanum nudum Dunal (wildand in-vitro). Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 2022; 21(1): 41–50"
                    },
                    {
                        "key": "ref29",
                        "doi": "10.3390/plants10061085",
                        "unstructured": "Gaia AM, Yamaguchi LF, Guerrero-Perilla C and KatoMJ: Ontogenetic changes in the chemical profiles of Piper species. Plants 2021; 10(6): 1085"
                    },
                    {
                        "key": "ref30",
                        "doi": "10.3390/plants11121590",
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                        "unstructured": "Martínez-Casares RM, Hernández-Vázquez L, Mandujano A, Sánchez-Pérez L, Pérez-Gutiérrez S and Pérez-RamosJ: Anti-inflammatory and cytotoxicactivities of clerodane- type diterpenes. Molecules 2023; 28(12): 4744"
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                        "unstructured": "Barbosa H, Thevenard F, Quero Reimão J, Tempone AG, Honorio KM and Lago JHG: The potential of secondary metabolites from plants as drugs or leads against Trypanosoma cruzi An update from 2012 to 2022. Current Topics in Medicinal Chemistry 2023; 23(3): 159–213"
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                        "unstructured": "Bezerra CWC, de Medeiros RMT, Rivero BRC, Dantas AFM and Amaral, FRC: Plantas tóxicas para rumiantes e equídeos da microrregião do Cariri Cearense. Ciência Rural, Santa Maria 2012; 42: 1070-1076"
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                        "unstructured": "Paniagua-Zambrana NY, Bussmann RW, Echeverría J and RomeroC: Solanum albidum Dunal, SolanumamericanumMill., Solanum fragile Wedd., Solanum herba-bonaReiche, Solanum mammosum L., Solanum marginatum L., Solanum nigrum L., Solanum nitidum Ruiz & Pav., Solanum nudum Dunal, Solanaceae. In: Paniagua- zambrana, N., Bussmann, R. (eds) Ethnobotany of the Andes. Ethnobotany of Mountain Regions. Springer,Cham 2020. 2_270-1"
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                        "key": "ref40",
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                        "unstructured": "Mahajan VD and Shaikh HS: Solanum nigrum A potential medicinal herb. Research Journal of Science and Technology 2023; 15(1): 27–34"
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                        "unstructured": "Mesa-Vanegas AM, Naranjo-Gómez EJ, Cardona F, Atehortúa-Garcés L, Blair-Trujillo S: Quantitative standardization of pharmacologically active components from Solanum nudum Dunal. Boletin Latinoamericano y Del Caribe de Plantas Medicinales y Aromaticas 2022; 21(1): 41–50"
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                        "unstructured": "Hassan AA, Khalid HE, Abdalla AH, Mukhtar MM, Osman WJ and Efferth T: Antileishmanial activities of medicinal herbs and phytochemicals in-vitro and in-vivo: An update for the years 2015 to 2021. Molecules 2022; 27(21): 7579"
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                        "unstructured": "Braguini WL, Pires NV and Alves BB: Phytochemical analysis, antioxidant properties, and brine shrimp lethality of unripe fruits of Solanum viarum. Journal of Young Pharmacists 2018; 10(2): 159–163"
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                    "value": "Chagas is one of the most common illnesses in Latin America. Chagas and Trypanosomacruzi are treated with benznidazole and nifurtimoxis, but these treatments are unsuccessful in the chronic phase of epimastigote and El Salvador. Thus, there is an urgent need for the creation of new medications, particularly for the chronic stage of the illness, according to the author. We examined 114 plant species from the Salvadoran flora using the in-vitro anti-Marvin J. Núñez trypanosome assay, and 34 active plants against the stepimastigote of Trypanosomacruzi Research Scholar were found",
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                        "unstructured": "Cucunubá ZM, Gutiérrez-Romero SA, Ramírez JD, Velásquez-Ortiz N, Ceccarelli S, Parra-Henao G, Henao-MartínezAF, Rabinovich J, BasáñezMG, NouvelletP and Abad-Franch F: The epidemiology of Chagas disease inthe Americas. The Lancet Regional Health–Americas2024; 37: 100881"
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                        "key": "ref2",
                        "doi": "10.3390/plants13030360",
                        "unstructured": "Núñez MJ, Martínez ML, Castillo UG, Flores KC, Menjívar J, López-Arencibia A, Bethencourt-Estrella CJ, Jiménez IA, Piñero JE, Lorenzo-Morales J and Bazzocchi IL: Salvadoran Celastraceae species as a source of antikinetoplastid quinonemethide triterpenoids. Plants 2024; 13(3): 360"
                    },
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                        "key": "ref3",
                        "unstructured": "MINSAL M de S de ESD de E. Casos sospechosos of Chagas agudo y crónico [Internet]. [place unknown]"
                    },
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                        "key": "ref4",
                        "doi": "10.1002/vms3.912",
                        "unstructured": "Nekoei S, Khamesipour F, Habtemariam S, de Souza W, Pour PM and Hosseini SR: The anti-Trypanosoma activities of medicinal plants: A systematic review of the literature. Veterinary Medicine and Science 2022; 8: 2738–2772"
                    },
                    {
                        "key": "ref5",
                        "doi": "10.1007/s11418-021-01562-6",
                        "unstructured": "CastilloUG, KomatsuA, MartínezML, MenjívarJ, Núñez MJ, Uekusa Y, Narukawa Y, Kiuchi F and Nakajima-Shimada J: Anti-trypanosomal screening of Salvadoran flora. Journal Natural Medicine 2022; 76: 259–267"
                    },
                    {
                        "key": "ref6",
                        "doi": "10.1021/acs.jnatprod.4c00022",
                        "unstructured": "Castillo UG, Uekusa Y, Nishimura T, Kiuchi F, Martínez ML, Menjívar J, Nakajima-Shimada J, Núñez MJ and Kikuchi H: Anti-trypanosomal lignans isolated from Salvadoran Peperomia pseudopereskiifolia. Journal of Natural Products 2024; 87: 1067–1074"
                    },
                    {
                        "key": "ref7",
                        "doi": "10.1016/j.jics.2021.100231",
                        "unstructured": "Amala AR and Joseph SM: Anticancer potential ofAnnona genus: A detailed review. Journal of the Indian ChemicalSociety2021;98(12):100231"
                    },
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                        "key": "ref8",
                        "doi": "10.1016/j.foodchem.2024.140363",
                        "unstructured": "Moussa AY, Siddiqui SA, Elhawary EA, Guo K, Anwar S and Xu B: Phytochemical constituents, bioactivities and applications of custard apple (Annona squamosa L.): A narrativereview. FoodChemistry2024;459:140363"
                    },
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                        "key": "ref9",
                        "doi": "10.3390/molecules27113462",
                        "unstructured": "Al Kazman BS, Harnett M and Hanrahan JR: Traditional uses, phytochemistry and pharmacological activities of Annonacae. Molecules 2022; 27(11): 3462"
                    },
                    {
                        "key": "ref10",
                        "doi": "10.3390/plants12020322",
                        "unstructured": "Soto-Vásquez MR, Alvarado-García PA, Osorio EH, Tallini LR and Bastida J: Antileishmanial activity of Clinanthus milagroanthus S. Leiva & Meerow (Amaryllidaceae)collectedinPeru. Plants2023;12(2):322"
                    },
                    {
                        "key": "ref11",
                        "unstructured": "Delgado-ParedesGE, Delgado-RojasPRandRojas-Idrogo C: Potential of the flora of Peruemphasizingin the Asteraceae family against Trypanosomacruzi. Revista Cubana de Medicina Tropical 2024;76"
                    },
                    {
                        "key": "ref12",
                        "doi": "10.1016/j.cbi.2021.109390",
                        "unstructured": "Rocha GN da SAO, Dutra LM, Lorenzo VP and DOI:https://doi.org/10.46243/jst.2024.v9.i02.pp01-1076 M. Vamshi Krishna, I. Devi, M. Sravya, Ch. Ajay Babu: Neuroprotective Potential of a Polyherbal Formulation in Enhancing Mental Clarity and Emotional Stability Almeida JRG da S: Phytochemicals and biological properties of Annona coriacea Mart. (Annonaceae): A systematicreviewfrom1971to2020.Chemico-Biological Interactions 2021; 336: 109390"
                    },
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                        "key": "ref13",
                        "doi": "10.1002/vms3.912",
                        "unstructured": "ShahinNekoe, F, KhamesipourF,HabtemariamS,deSW, Mohammadi Pour P and Hossein SR: The anti-trypanosoma activities of medicinal plants: A systematic review of the literature. Veterinary Medicine and Science 2022; 8(6): 2738–2772"
                    },
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                        "key": "ref14",
                        "doi": "10.1016/j.phytochem.2018.10.022",
                        "unstructured": "Gogineni V, Nael MA, León F, Núñez MJ and Cutler SJ: Computationally aidedstereochemical assignmentof undescribed bisabolenes from Calea urticifolia. Phytochemistry 2019; 157:145–"
                    },
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                        "key": "ref15",
                        "doi": "10.1016/j.phyplu.2022.100377",
                        "unstructured": "KamarajC, RagavendranC, KumarRCS,AliA, KhanSU, Mashwani Z ur-R, Luna-Arias JP and Pedroza JPR: Antiparasitic potential of Asteraceae plants: A comprehensive review on therapeutic and mechanistic aspects for biocompatible drug discovery. Phytomedicine Plus2022; 2(4):100377"
                    },
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                        "key": "ref16",
                        "doi": "10.1021/acs.jnatprod.6b00440",
                        "unstructured": "Chaurasiya ND, Gogineni V, Elokely KM, León F, Núñez MJ, Klein ML, Walker LA, Cutler SJ and Tekwani BL: Isolation of acacetin from Calea urticifolia with inhibitory properties against Human Monoamine Oxidase-A and-B. Journal of Natural Products 2016; 79:2538–2544"
                    },
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                        "key": "ref17",
                        "doi": "10.5897/jmpr2017.6412",
                        "unstructured": "Amaral P, Costa FV, Antunes AR, Kautz J, Citadini-ZanetteV, DévéhatFLL, BarlowJand DalBóS:Thegenus Calea L.: A review of isolated compounds and biological activities. Journal of Medical Plants Research 2017; 11:518–537"
                    },
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                        "key": "ref18",
                        "doi": "10.1016/j.bjp.2018.01.010",
                        "unstructured": "Mijangos-Ramos IF, Zapata-Estrella HE, Ruiz-Vargas JA, Escalante-Erosa F, Gómez-Ojeda N, García-Sosa K, Cechinel-Filho V, Meira-Quintão NL and Peña-Rodríguez LM: Bioactive dicaffeoylquinic acid derivatives from the root extract of Calea urticifolia. Revista Brasileira de Farmacognosia 2018; 28:339–343"
                    },
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                        "key": "ref19",
                        "doi": "10.1002/ptr.6010",
                        "unstructured": "Cardoso T, Souza R de J, da Silva FA and Biavatti MW: The genus Calea L.: A review on traditional uses, phytochemistry, and biological activities. Phytotherapy Research 2018; 32: 769–795"
                    },
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                        "key": "ref20",
                        "doi": "10.21577/0100-4042.20170728",
                        "unstructured": "Lima TC, Souza RJ, Moraes MH, Matos SS, Almeida FHO, Steindel M and Biavatti MW: Isolation and characterization of sesquiterpenela ctonesfromCalea uniflora Less. and their leishmanicidal and trypanocidal activities. Química Nova 2021; 44(6): 696–699"
                    },
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                        "key": "ref21",
                        "doi": "10.14715/cmb/2022.68.10.19",
                        "unstructured": "Naik N, Kaushal RS, Upadhyay TK, Kahrizi D, Al-Najjar MA, Khan MS and Siddiqui S: Role of natural plant extracts for potential antileishmanial targets-In-depth review of the molecular mechanism. Cellular and Molecular Biology 2022; 68(10): 117–123"
                    },
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                        "key": "ref22",
                        "doi": "10.21577/0100-4042.20170728",
                        "unstructured": "Lima TC, Souza RJ, Morales MH, Matos SS, Almeida FHO, Steindel M and Biavatti MW: Isolation and characterization of sesquiterpene lactones from Calea uniflora less. and their leishmanicidal and trypanocidal activities. Quimica Nova 2021; 44(6): 696–699"
                    },
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                        "key": "ref23",
                        "doi": "10.52403/ijrr.20231138",
                        "unstructured": "Babu NJ, Ambika K and Rao GN: Genus Vernonia Mini Review. International Journal of Research and Review 2023; 10(11): 325–327"
                    },
                    {
                        "key": "ref24",
                        "doi": "10.2174/2212798412666230330164954",
                        "unstructured": "Mishra N, Gupta E, Singh P, Soni S and Noor U: Insighton Vernonia plant for its pharmacological properties: A review. Recent Advances in Food Nutrition & Agriculture 2023; 14(2): 84–93"
                    },
                    {
                        "key": "ref25",
                        "doi": "10.3389/fphar.2019.00477",
                        "unstructured": "Moraes Neto RN, Setúbal RFB, Higino TMM, Brelaz-de-CastroMCA, Nascimentoda SilvaLC and AliançaASDS: Asteraceae plants as sources of compounds against Leishmaniasis and Chagas disease. Frontiers in Pharmacology 2019; 10:477"
                    },
                    {
                        "key": "ref26",
                        "doi": "10.1007/s00436-021-07199-4",
                        "unstructured": "Peixoto JF, Ramos YJ, de Lima Moreira D, Alves CR and Folcalves-Oliveira LF: Potential of Piper spp. as a source of new compounds for the leishmaniases treatment. Parasitology Research 2021; 120: 2731–2747"
                    },
                    {
                        "key": "ref27",
                        "doi": "10.21608/aprh.2024.225955.1230",
                        "unstructured": "Mbadiko C, Bongo G, Ngbolua KTN, Ngombe N, Kapepula P, Yandju MC, Mpiana P and Mbemba T: Uses, phytochemistry and biological activity of Piper genus: A review. Journal of Medicinal Herbs 2023; 14(1): 1–17"
                    },
                    {
                        "key": "ref28",
                        "doi": "10.37360/blacpma.22.21.1.02",
                        "unstructured": "Mesa-Vanegas AM, Naranjo-Gómez EJ, Cardona F, Atehortúa-Garcés L and Blair-Trujillo S: Quantitative standardization of pharmacologically active components from antiplasmodial plant Solanum nudum Dunal (wildand in-vitro). Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 2022; 21(1): 41–50"
                    },
                    {
                        "key": "ref29",
                        "doi": "10.3390/plants10061085",
                        "unstructured": "Gaia AM, Yamaguchi LF, Guerrero-Perilla C and KatoMJ: Ontogenetic changes in the chemical profiles of Piper species. Plants 2021; 10(6): 1085"
                    },
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                        "key": "ref30",
                        "doi": "10.3390/plants11121590",
                        "unstructured": "Armijos C, Ramírez J and Vidari G: Poorly investigated Ecuadorian medicinal plants. Plants 2022; 11(12): 1590. DOI:https://doi.org/10.46243/jst.2024.v9.i02.pp01-1077 M. Vamshi Krishna, I. Devi, M. Sravya, Ch. Ajay Babu: Neuroprotective Potential of a Polyherbal Formulation in Enhancing Mental Clarity and Emotional Stability"
                    },
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                        "key": "ref31",
                        "doi": "10.55373/mjchem.v24i4.201",
                        "unstructured": "Salleh WMNHW and Ab GhaniN: Minireviewonbotany, traditionaluses, phytochemistry and biologicalactivities of Piper amalago (Piperaceae). Malaysian Journal of Chemistry 2022; 24(4): 201–208"
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                        "key": "ref32",
                        "doi": "10.1007/s12229-020-09239-7",
                        "unstructured": "dos Santos VLP, Rodrigues ICG, Berté R, Vijayasankar Raman, Messias-Reason IJ and Budel JM: Review of Pipers pecies growing in the Brazilian State of Paraná with emphasis on the vegetative anatomy and biological activities. Botanical Review 2021; 87: 23–54"
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                        "key": "ref33",
                        "doi": "10.1002/cbdv.202300492",
                        "unstructured": "Carvalho FA, de Moraes NV, Crotti AEM, Crevelin EJand Dos Santos AG: Casearia essential oil: An updated review on the chemistry and pharmacological activities. Chemical Biodiversity 2023; 20:e202300492"
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                        "key": "ref34",
                        "doi": "10.1021/acs.jnatprod.1c00840",
                        "unstructured": "Syafni N, Faleschini MT, Garifulina A, Danton O, Gupta MP, Hering S and Hamburger M: Clerodane diterpenes from Casearia corymbosa as allosteric GABA A receptor modulators. Journal of Natural Products 2022; 85(5): 1201–1210"
                    },
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                        "key": "ref35",
                        "doi": "10.3390/molecules28124744",
                        "unstructured": "Martínez-Casares RM, Hernández-Vázquez L, Mandujano A, Sánchez-Pérez L, Pérez-Gutiérrez S and Pérez-RamosJ: Anti-inflammatory and cytotoxicactivities of clerodane- type diterpenes. Molecules 2023; 28(12): 4744"
                    },
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                        "key": "ref36",
                        "doi": "10.1021/acs.jnatprod.1c00840",
                        "unstructured": "Syafni N, Faleschini MT, Garifulina A, Danton O, Gupta MP, Hering S and Hamburger M: Clerodane diterpenes from Casearia corymbosa as allosteric GABAA receptor modulators. Journal of Natural Products 2022; 85:1201–1210"
                    },
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                        "key": "ref37",
                        "doi": "10.2174/1568026623666221212111514",
                        "unstructured": "Barbosa H, Thevenard F, Quero Reimão J, Tempone AG, Honorio KM and Lago JHG: The potential of secondary metabolites from plants as drugs or leads against Trypanosoma cruzi An update from 2012 to 2022. Current Topics in Medicinal Chemistry 2023; 23(3): 159–213"
                    },
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                        "key": "ref38",
                        "doi": "10.1590/s0103-84782012000600020",
                        "unstructured": "Bezerra CWC, de Medeiros RMT, Rivero BRC, Dantas AFM and Amaral, FRC: Plantas tóxicas para rumiantes e equídeos da microrregião do Cariri Cearense. Ciência Rural, Santa Maria 2012; 42: 1070-1076"
                    },
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                        "key": "ref39",
                        "doi": "10.1007/978-3-319-77093-2_270-1",
                        "unstructured": "Paniagua-Zambrana NY, Bussmann RW, Echeverría J and RomeroC: Solanum albidum Dunal, SolanumamericanumMill., Solanum fragile Wedd., Solanum herba-bonaReiche, Solanum mammosum L., Solanum marginatum L., Solanum nigrum L., Solanum nitidum Ruiz & Pav., Solanum nudum Dunal, Solanaceae. In: Paniagua- zambrana, N., Bussmann, R. (eds) Ethnobotany of the Andes. Ethnobotany of Mountain Regions. Springer,Cham 2020. 2_270-1"
                    },
                    {
                        "key": "ref40",
                        "doi": "10.52711/2349-2988.2023.00006",
                        "unstructured": "Mahajan VD and Shaikh HS: Solanum nigrum A potential medicinal herb. Research Journal of Science and Technology 2023; 15(1): 27–34"
                    },
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                        "key": "ref41",
                        "doi": "10.37360/blacpma.22.21.1.02",
                        "unstructured": "Mesa-Vanegas AM, Naranjo-Gómez EJ, Cardona F, Atehortúa-Garcés L, Blair-Trujillo S: Quantitative standardization of pharmacologically active components from Solanum nudum Dunal. Boletin Latinoamericano y Del Caribe de Plantas Medicinales y Aromaticas 2022; 21(1): 41–50"
                    },
                    {
                        "key": "ref42",
                        "doi": "10.3390/molecules27217579",
                        "unstructured": "Hassan AA, Khalid HE, Abdalla AH, Mukhtar MM, Osman WJ and Efferth T: Antileishmanial activities of medicinal herbs and phytochemicals in-vitro and in-vivo: An update for the years 2015 to 2021. Molecules 2022; 27(21): 7579"
                    },
                    {
                        "key": "ref43",
                        "doi": "10.5530/jyp.2018.10.36",
                        "unstructured": "Braguini WL, Pires NV and Alves BB: Phytochemical analysis, antioxidant properties, and brine shrimp lethality of unripe fruits of Solanum viarum. Journal of Young Pharmacists 2018; 10(2): 159–163"
                    }
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