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Using PubMed, Google Scholar and Web of Science, we searched for publications in the last 10 years regarding the role of VD in PCOS students. It was found that the prevalence of VD deficiency was higher in PCOS subjects in comparison to control. We compared the effects of supplementation of VD in PCOS patients on insulin resistance (IR) value and oxidative stress markers (MDA). It was found that VD as a co-supplement could significantly decrease fasting glucose concentrations and the HOMAIR value. Further VD supplementation in patients with PCOS resulted in a significant improvement in high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0", "start": "2021-08-31", "applies_to": "vor" }, "references": [ { "key": "ref1", "doi": "10.4103/0971-5916.166527", "unstructured": "Ming-Wei Lin and Meng-Hsing Wu. 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The effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with polycystic ovary syndrome. Exp. Clin. Endocrinol. Diabetes. 2017, 125: 316–321" }, { "key": "ref12", "doi": "10.1007/s00394-018-1760-8", "unstructured": "Trummer C, Schwez V, Kollmann M, et al. Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial. Eur J Nutr 2019, 58: 2019-28" }, { "key": "ref13", "doi": "10.1100/2012/741861", "unstructured": "Mishra P, Samanta L. Oxidative stress and heart failure in altered thyroid states. The scientific world journal. 2012. 2012, 1-17" }, { "key": "ref14", "unstructured": "N. I. Khan, L. Naz, and G. Yasmeen. Obesity: an independent risk factor for systemic oxidative stress. Pakistan Journal of Pharmaceutical Sciences. 2006, 19(1): 62–65" }, { "key": "ref15", "doi": "10.1093/humupd/dms059", "unstructured": "M. Murri, M. Luque-ramírez, M. Insenser, M. Ojeda-ojeda, and H. F. Escobarmorreale. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Human Reproduction Update. 2013,19(3): 268–288" }, { "key": "ref16", "doi": "10.1089/ars.2005.7.1553", "unstructured": "Bloch-Damti and N. Bashan. Proposed mechanisms for the induction of insulin resistance by oxidative stress, Antioxidants & Redox Signaling. 2005, 7(11-12): 1553–1567" }, { "key": "ref17", "doi": "10.3390/biology8020030", "unstructured": "Sunil J. Wimalawansa. Vitamin D deficiency: effects on oxidative stress, epigenetics, gene regulation and ageing, Biology(Basel), 2019, 8(2): 30" }, { "key": "ref18", "doi": "10.1620/tjem.230.59", "unstructured": "Sung JY, Chung W, Kim AJ, et al. Calcitriol treatment increases serum levels of the soluble receptor of advanced glycation end products in hemodialysis patients with secondary hyperparathyroidism. Tohoku J Exp Med. 2013, 230(1): 59–66" }, { "key": "ref19", "doi": "10.1371/journal.pone.0131740", "unstructured": "Liefaard MC, Ligthart S, et al. Vitamin D and C-Reactive Protein: A Mendelian Randomization Study. Plos one. 2015, 10(7): e0131740" }, { "key": "ref20", "doi": "10.1111/cen.12840", "unstructured": "Foroozanfard F, Jamilian M, Bahmani F, et al. Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidative stress in overweight and vitaminD-deficient women with polycystic ovary syndrome: a randomized doubleblind placebo-controlled clinical trial. Clin Endocrinol (Oxf). 2015, 83: 888-94" }, { "key": "ref21", "doi": "10.1055/s-0042-104060", "unstructured": "Razavi M, Jamillian M, Karamali M, et al. The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in VitaminD-Deficient Women with Polycystic Ovary Syndrome:A Randomized, Double-Blind,PlaceboControlled Trial. Horm Metab Res 2016, 48: 446-51" }, { "key": "ref22", "doi": "10.3390/nu9121280", "unstructured": "Jamilian M, Foroozanfard F, Rahmani E, et al. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome. Nutrients. 2017, 9: 1280. Ovary Syndrome. Nutrients 2019, 11: 188" }, { "key": "ref23", "doi": "10.1016/j.clnesp.2017.01.002", "unstructured": "Fatemi F, Mohammadzadeh A, Sadeghi MR, et al. Role of vitamin E and D3 supplementation in Intra-Cytoplasmic Sperm Injection outcomes of women with polycystic ovarian syndrome: A double blinded randomized placebocontrolled trial. Clin Nutr ESPEN. 2017, 18: 23-30" }, { "key": "ref24", "doi": "10.1080/07435800.2017.1346661", "unstructured": "Nasri K, Akrami S, Rahimi M, et al. The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D- P age 223 | 11 Published by: Longman Publishers www.jst.org.in deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Endocr Res. 2018, 43: 1-10" }, { "key": "ref25", "doi": "10.1007/s12011-017-1085-0", "unstructured": "Maktabi M, Jamilian M, Asemi Z. Magnesium-ZincCalcium-Vitamin D Cosupplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, PlaceboControlled Trial. Biol Trace Elem Res. 2018, 182: 21-8" }, { "key": "ref26", "doi": "10.1186/s13048-019-0480-x", "unstructured": "Ostadmohammadi V, Jamilian M, Bahani F, et al. Vitamin D and probiotic cosupplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J Ovarian Res, 2019, 12: 5" } ], "record": { "registrant": "Longman Publishers", "registered": "2026-09-10", "updated": "2026-09-20", "issue_number": 1, "source": "crossref-api", "source_agency": "Crossref (member 25296)" } }, "url_after": "https://www.jst.org.in/index.php/pub/article/view/628", "sha256_before": null, "sha256_after": "174c2a6c87b63da3cb43e9fab5a70a295293a015fd035539e81865e5e57c49cc" }, { "seq": 2, "kind": "update", "at": "2026-09-29 23:59:57", "by": "Administrator (admin)", "by_kind": "user", "note": "record re-read from api.crossref.org", "changes": [ { "path": "container.titles.0.value", "from": "Journal of Science & Technology", "to": "Journal of Science & Technology" } ], "record_after": { "format": "smartscholars-doi-metadata/1.0", "doi": "10.46243/jst.2021.v6.i04.pp216-226", "referent": "Creation", "type": "JournalArticle", "structural_type": "Digital", "modes": [ "Visual" ], "characters": [ "Language" ], "titles": [ { "value": "Supplementation of Vitamin D improves Insulin Resistance and Oxidative Stress in PCOS women. A Comprehensive Review", "type": "PrincipalTitle", "lang": "en" } ], "identifiers": [ { "type": "DOI", "value": "10.46243/jst.2021.v6.i04.pp216-226" } ], "agents": [ { "role": "author", "name": { "given": "Pallavi", "family": "Mishra" }, "sequence": "first" }, { "role": "author", "name": { "given": "Arpita", "family": "Nanda" }, "sequence": "additional" }, { "role": "publisher", "name": { "org": "Longman Publishers" } } ], "dates": { "published": "2021-08-31", "date_type": "PublicationDate", "online": "2021-08-31" }, "language": "en", "container": { "type": "Journal", "titles": [ { "value": "Journal of Science & Technology", "type": "PrincipalTitle" } ], "identifiers": [ { "type": "ISSN", "value": "2456-5660", "medium": "electronic" } ], "volume": "06", "issue": "04", "pages": { "first": "216", "last": "226" } }, "links": [ { "url": "https://www.jst.org.in/index.php/pub/article/view/628", "return_type": "text/html", "primary": true }, { "url": "https://www.jst.org.in/index.php/pub/article/download/628/560", "purpose": "text-mining", "return_type": "application/pdf" }, { "url": "https://www.jst.org.in/index.php/pub/article/download/628/2801", "purpose": "text-mining", "return_type": "application/xml" }, { "url": "https://www.jst.org.in/index.php/pub/article/view/628/560", "purpose": "similarity-checking" } ], "abstract": { "value": "The aim of the present review was to evaluate the effect of vitamin D (VD) supplementation (alone or co-supplementation) on insulin resistance and oxidative stress in VD deficient polycystic ovary syndrome (PCOS) subjects. Using PubMed, Google Scholar and Web of Science, we searched for publications in the last 10 years regarding the role of VD in PCOS students. It was found that the prevalence of VD deficiency was higher in PCOS subjects in comparison to control. We compared the effects of supplementation of VD in PCOS patients on insulin resistance (IR) value and oxidative stress markers (MDA). It was found that VD as a co-supplement could significantly decrease fasting glucose concentrations and the HOMAIR value. Further VD supplementation in patients with PCOS resulted in a significant improvement in high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0", "start": "2021-08-31", "applies_to": "vor" }, "references": [ { "key": "ref1", "doi": "10.4103/0971-5916.166527", "unstructured": "Ming-Wei Lin and Meng-Hsing Wu. The role of vitamin D in Polycystic ovary syndrome, Indian J Med Res. 2015 Sep, 142(3): 238–240" }, { "key": "ref2", "doi": "10.1093/humupd/dmr001", "unstructured": "de Groot PC, Dekkers OM, Romijn JA, Dieben SW & Helmerhorst FM. PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Human Reproduction Update. 2011, 17: 495–500" }, { "key": "ref3", "doi": "10.1210/er.2011-1034", "unstructured": "Diamanti-Kandarakis E & Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocrine Reviews. 2012, 33: 981–1030" }, { "key": "ref4", "doi": "10.1016/j.fertnstert.2010.12.027", "unstructured": "Wild RA, Rizzo M, Clifton S & Carmina E. Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis. Fertility and Sterility. 2011, 95: 1073–1079" }, { "key": "ref5", "doi": "10.1016/j.fertnstert.2014.02.021", "unstructured": "Raja-Khan, N. Shah, J. Stetter, C.M. 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The effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with polycystic ovary syndrome. Exp. Clin. Endocrinol. Diabetes. 2017, 125: 316–321" }, { "key": "ref12", "doi": "10.1007/s00394-018-1760-8", "unstructured": "Trummer C, Schwez V, Kollmann M, et al. Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial. Eur J Nutr 2019, 58: 2019-28" }, { "key": "ref13", "doi": "10.1100/2012/741861", "unstructured": "Mishra P, Samanta L. Oxidative stress and heart failure in altered thyroid states. The scientific world journal. 2012. 2012, 1-17" }, { "key": "ref14", "unstructured": "N. I. Khan, L. Naz, and G. Yasmeen. Obesity: an independent risk factor for systemic oxidative stress. Pakistan Journal of Pharmaceutical Sciences. 2006, 19(1): 62–65" }, { "key": "ref15", "doi": "10.1093/humupd/dms059", "unstructured": "M. Murri, M. Luque-ramírez, M. Insenser, M. Ojeda-ojeda, and H. F. Escobarmorreale. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Human Reproduction Update. 2013,19(3): 268–288" }, { "key": "ref16", "doi": "10.1089/ars.2005.7.1553", "unstructured": "Bloch-Damti and N. Bashan. Proposed mechanisms for the induction of insulin resistance by oxidative stress, Antioxidants & Redox Signaling. 2005, 7(11-12): 1553–1567" }, { "key": "ref17", "doi": "10.3390/biology8020030", "unstructured": "Sunil J. Wimalawansa. Vitamin D deficiency: effects on oxidative stress, epigenetics, gene regulation and ageing, Biology(Basel), 2019, 8(2): 30" }, { "key": "ref18", "doi": "10.1620/tjem.230.59", "unstructured": "Sung JY, Chung W, Kim AJ, et al. Calcitriol treatment increases serum levels of the soluble receptor of advanced glycation end products in hemodialysis patients with secondary hyperparathyroidism. Tohoku J Exp Med. 2013, 230(1): 59–66" }, { "key": "ref19", "doi": "10.1371/journal.pone.0131740", "unstructured": "Liefaard MC, Ligthart S, et al. Vitamin D and C-Reactive Protein: A Mendelian Randomization Study. Plos one. 2015, 10(7): e0131740" }, { "key": "ref20", "doi": "10.1111/cen.12840", "unstructured": "Foroozanfard F, Jamilian M, Bahmani F, et al. Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidative stress in overweight and vitaminD-deficient women with polycystic ovary syndrome: a randomized doubleblind placebo-controlled clinical trial. Clin Endocrinol (Oxf). 2015, 83: 888-94" }, { "key": "ref21", "doi": "10.1055/s-0042-104060", "unstructured": "Razavi M, Jamillian M, Karamali M, et al. The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in VitaminD-Deficient Women with Polycystic Ovary Syndrome:A Randomized, Double-Blind,PlaceboControlled Trial. Horm Metab Res 2016, 48: 446-51" }, { "key": "ref22", "doi": "10.3390/nu9121280", "unstructured": "Jamilian M, Foroozanfard F, Rahmani E, et al. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome. Nutrients. 2017, 9: 1280. Ovary Syndrome. Nutrients 2019, 11: 188" }, { "key": "ref23", "doi": "10.1016/j.clnesp.2017.01.002", "unstructured": "Fatemi F, Mohammadzadeh A, Sadeghi MR, et al. Role of vitamin E and D3 supplementation in Intra-Cytoplasmic Sperm Injection outcomes of women with polycystic ovarian syndrome: A double blinded randomized placebocontrolled trial. Clin Nutr ESPEN. 2017, 18: 23-30" }, { "key": "ref24", "doi": "10.1080/07435800.2017.1346661", "unstructured": "Nasri K, Akrami S, Rahimi M, et al. The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D- P age 223 | 11 Published by: Longman Publishers www.jst.org.in deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Endocr Res. 2018, 43: 1-10" }, { "key": "ref25", "doi": "10.1007/s12011-017-1085-0", "unstructured": "Maktabi M, Jamilian M, Asemi Z. Magnesium-ZincCalcium-Vitamin D Cosupplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, PlaceboControlled Trial. Biol Trace Elem Res. 2018, 182: 21-8" }, { "key": "ref26", "doi": "10.1186/s13048-019-0480-x", "unstructured": "Ostadmohammadi V, Jamilian M, Bahani F, et al. Vitamin D and probiotic cosupplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. 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