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The cytotoxicity of ethanolic extract was analyzed, using MTT assay and flow cytometric analysis. It was noticed that IC50 value of Opunria elatior curde extract was 74.32 µl/ml showing its cytotoxicity in the human blood cancer cell line by using MTT assay. The flow cytometry evaluation exhibits cell arrested in G2/M and S phases. Cell arrested due to Opuntia elatior extract shows higher than positive control Cisplatin. Thus Opuntia elatior fruit extract might be used as potent source of anticancerous compound against human blood cancer", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2021-07-14", "applies_to": "vor" }, "references": [ { "key": "ref1", "unstructured": "Aziz, A., Taha H., Mohebali N., Chung Y. L., Ismail N. H., Bakar M. Z. A. and Yusof F. Z. M., 2016. Anti-Cancer Potential of Pseuduvaria Macrophylla in Human Cancer Cell lines. 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H., Hsieh Y.L., Hsu H.H., Tu C.C., Bau D.T., Viswanadha V. P., Huang C.Y., 2015. Helioxanthin suppresses the cross talk of COX- 2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice. Environmental Toxicology. 31, 2045-2056" }, { "key": "ref18", "unstructured": "Mehrzad J. and Rajabi M., 2011. Kinetin (N6-furfuryladenine): Cytotoxicity against MCF-7 breast cancer cell line and interaction with bovine serum albumin. African Journal of Biotechnology. 10 (33), 6304-6309" }, { "key": "ref19", "unstructured": "Moammadpour R., Safarian S., Farahnak S., Hasheminasl S., Sheibani N., 2012. Journal of Cell and Molecular Biology. 10 (1), 41-54" }, { "key": "ref20", "doi": "10.1385/1-59259-811-0:301", "unstructured": "Pozarowski P.and Darzynkiewicz Z., 2004. Analysis of cell cycle by flow cytometry. 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Mane" }, "sequence": "additional" }, { "role": "author", "name": { "given": "", "family": "R. Patil" }, "sequence": "additional" }, { "role": "publisher", "name": { "org": "Longman Publishers" } } ], "dates": { "published": "2021-07-14", "date_type": "PublicationDate", "online": "2021-07-14" }, "language": "en", "container": { "type": "Journal", "titles": [ { "value": "Journal of Science & Technology", "type": "PrincipalTitle" } ], "identifiers": [ { "type": "ISSN", "value": "2456-5660", "medium": "electronic" } ], "volume": "06", "issue": "04", "pages": { "first": "32", "last": "38" } }, "links": [ { "url": "https://www.jst.org.in/index.php/pub/article/view/433", "return_type": "text/html", "primary": true }, { "url": "https://www.jst.org.in/index.php/pub/article/download/433/385", "purpose": "text-mining", "return_type": "application/pdf" }, { "url": "https://www.jst.org.in/index.php/pub/article/download/433/2921", "purpose": "text-mining", "return_type": "application/xml" }, { "url": "https://www.jst.org.in/index.php/pub/article/view/433/385", "purpose": "similarity-checking" } ], "abstract": { "value": "The ethanolic extract of Opuntia elatior was studied for anticancer potential against human blood cancer cell line K-562. The cytotoxicity of ethanolic extract was analyzed, using MTT assay and flow cytometric analysis. It was noticed that IC50 value of Opunria elatior curde extract was 74.32 µl/ml showing its cytotoxicity in the human blood cancer cell line by using MTT assay. The flow cytometry evaluation exhibits cell arrested in G2/M and S phases. Cell arrested due to Opuntia elatior extract shows higher than positive control Cisplatin. Thus Opuntia elatior fruit extract might be used as potent source of anticancerous compound against human blood cancer", "lang": "en" }, "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "start": "2021-07-14", "applies_to": "vor" }, "references": [ { "key": "ref1", "unstructured": "Aziz, A., Taha H., Mohebali N., Chung Y. L., Ismail N. H., Bakar M. Z. A. and Yusof F. Z. M., 2016. Anti-Cancer Potential of Pseuduvaria Macrophylla in Human Cancer Cell lines. 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