{
    "ok": true,
    "doi": "10.46243/jst.2020.v5.i4.pp288-307",
    "events": [
        {
            "seq": 1,
            "kind": "register",
            "at": "2026-09-29 22:00:23",
            "by": "Administrator (admin)",
            "by_kind": "user",
            "note": "registered at Crossref; record read from api.crossref.org",
            "changes": [
                {
                    "path": "abstract.lang",
                    "from": null,
                    "to": "en"
                },
                {
                    "path": "abstract.value",
                    "from": null,
                    "to": ": Isatin is a naturally occurring substance identified in humans, animals, plants and coal tar. Isatin derivatives are reported to possess a wide range of activites. This review is in continuation of “Part-1 (1877-2002)” review published by our team. This review encompasses the most signigicant reports published during 2002 to 2020 on the biological & pharmacological activites of isatin and its derivatives. The review includes the various synthetic reactions of isatin and activites reported. The pharmacological and biological activites reported were antimicrobial, antineoplastic & related activities; analgesic, anti-inflammatory, anticonvulsant, antioxidant, activity against veterinary pathogen, effects on cardiac & vascular smooth muscles; transthyretin fibrillogenesis inhibitor and antiglycation activity of isatin compounds."
                },
                {
                    "path": "agents.0.name.family",
                    "from": null,
                    "to": "Aditi Namboodiripad"
                },
                {
                    "path": "agents.0.name.given",
                    "from": null,
                    "to": ""
                },
                {
                    "path": "agents.0.role",
                    "from": null,
                    "to": "author"
                },
                {
                    "path": "agents.0.sequence",
                    "from": null,
                    "to": "first"
                },
                {
                    "path": "agents.1.name.family",
                    "from": null,
                    "to": "Nimal C N"
                },
                {
                    "path": "agents.1.name.given",
                    "from": null,
                    "to": ""
                },
                {
                    "path": "agents.1.role",
                    "from": null,
                    "to": "author"
                },
                {
                    "path": "agents.1.sequence",
                    "from": null,
                    "to": "additional"
                },
                {
                    "path": "agents.2.name.org",
                    "from": null,
                    "to": "Longman Publishers"
                },
                {
                    "path": "agents.2.role",
                    "from": null,
                    "to": "publisher"
                },
                {
                    "path": "characters.0",
                    "from": null,
                    "to": "Language"
                },
                {
                    "path": "container.identifiers.0.medium",
                    "from": null,
                    "to": "electronic"
                },
                {
                    "path": "container.identifiers.0.type",
                    "from": null,
                    "to": "ISSN"
                },
                {
                    "path": "container.identifiers.0.value",
                    "from": null,
                    "to": "2456-5660"
                },
                {
                    "path": "container.issue",
                    "from": null,
                    "to": "Volume 5"
                },
                {
                    "path": "container.pages.first",
                    "from": null,
                    "to": "288"
                },
                {
                    "path": "container.pages.last",
                    "from": null,
                    "to": "307"
                },
                {
                    "path": "container.titles.0.type",
                    "from": null,
                    "to": "PrincipalTitle"
                },
                {
                    "path": "container.titles.0.value",
                    "from": null,
                    "to": "Journal of Science &amp; Technology"
                },
                {
                    "path": "container.type",
                    "from": null,
                    "to": "Journal"
                },
                {
                    "path": "dates.date_type",
                    "from": null,
                    "to": "PublicationDate"
                },
                {
                    "path": "dates.online",
                    "from": null,
                    "to": "2020-07-30"
                },
                {
                    "path": "dates.published",
                    "from": null,
                    "to": "2020-07-30"
                },
                {
                    "path": "doi",
                    "from": null,
                    "to": "10.46243/jst.2020.v5.i4.pp288-307"
                },
                {
                    "path": "format",
                    "from": null,
                    "to": "smartscholars-doi-metadata/1.0"
                },
                {
                    "path": "identifiers.0.type",
                    "from": null,
                    "to": "DOI"
                },
                {
                    "path": "identifiers.0.value",
                    "from": null,
                    "to": "10.46243/jst.2020.v5.i4.pp288-307"
                },
                {
                    "path": "language",
                    "from": null,
                    "to": "en"
                },
                {
                    "path": "license.applies_to",
                    "from": null,
                    "to": "vor"
                },
                {
                    "path": "license.start",
                    "from": null,
                    "to": "2020-07-30"
                },
                {
                    "path": "license.url",
                    "from": null,
                    "to": "https://creativecommons.org/licenses/by/4.0"
                },
                {
                    "path": "links.0.primary",
                    "from": null,
                    "to": true
                },
                {
                    "path": "links.0.return_type",
                    "from": null,
                    "to": "text/html"
                },
                {
                    "path": "links.0.url",
                    "from": null,
                    "to": "https://www.jst.org.in/index.php/pub/article/view/336"
                },
                {
                    "path": "links.1.purpose",
                    "from": null,
                    "to": "text-mining"
                },
                {
                    "path": "links.1.return_type",
                    "from": null,
                    "to": "application/pdf"
                },
                {
                    "path": "links.1.url",
                    "from": null,
                    "to": "https://www.jst.org.in/index.php/pub/article/download/336/298"
                },
                {
                    "path": "links.2.purpose",
                    "from": null,
                    "to": "text-mining"
                },
                {
                    "path": "links.2.return_type",
                    "from": null,
                    "to": "application/xml"
                },
                {
                    "path": "links.2.url",
                    "from": null,
                    "to": "https://www.jst.org.in/index.php/pub/article/download/336/2501"
                },
                {
                    "path": "modes.0",
                    "from": null,
                    "to": "Visual"
                },
                {
                    "path": "record.issue_number",
                    "from": null,
                    "to": 1
                },
                {
                    "path": "record.registered",
                    "from": null,
                    "to": "2020-07-30"
                },
                {
                    "path": "record.registrant",
                    "from": null,
                    "to": "Longman Publishers"
                },
                {
                    "path": "record.source",
                    "from": null,
                    "to": "crossref-api"
                },
                {
                    "path": "record.source_agency",
                    "from": null,
                    "to": "Crossref (member 25296)"
                },
                {
                    "path": "record.updated",
                    "from": null,
                    "to": "2026-09-26"
                },
                {
                    "path": "references.0.key",
                    "from": null,
                    "to": "ref1"
                },
                {
                    "path": "references.0.unstructured",
                    "from": null,
                    "to": "Kardashev, N. S., “Transmission of information by Extraterrestrial c ivilizations,” Soviet Astronomy, Vol. 8, No. 2, Sept. -Oct. 1964"
                },
                {
                    "path": "references.1.key",
                    "from": null,
                    "to": "ref2"
                },
                {
                    "path": "references.1.unstructured",
                    "from": null,
                    "to": "Lamb, David, The Search for Extraterrestrial Intelligence: A Philosophical Inquiry, Routledge, London & New York, 2001, p. 182"
                },
                {
                    "path": "references.2.doi",
                    "from": null,
                    "to": "10.1093/acprof:oso/9780195171815.001.0001"
                },
                {
                    "path": "references.2.key",
                    "from": null,
                    "to": "ref3"
                },
                {
                    "path": "references.2.unstructured",
                    "from": null,
                    "to": "Basalla, George, Civilized Life in the Universe: Scientists on Intelligent Extraterrestrials,Oxford University Press, Oxford, 2006, p. 148"
                },
                {
                    "path": "references.3.key",
                    "from": null,
                    "to": "ref4"
                },
                {
                    "path": "references.3.unstructured",
                    "from": null,
                    "to": "Sagan, Carl, The Cosmic Connection: An Extraterrestrial Perspective, Cambridge University Press, 2000, Part Three, Chapter 34"
                },
                {
                    "path": "references.4.key",
                    "from": null,
                    "to": "ref5"
                },
                {
                    "path": "references.4.unstructured",
                    "from": null,
                    "to": "Kaku, Michio, The Physics of the Impossible, New York, et al.: Doubleday, 2008, p. 145"
                },
                {
                    "path": "references.5.key",
                    "from": null,
                    "to": "ref6"
                },
                {
                    "path": "references.5.unstructured",
                    "from": null,
                    "to": "Kaku, Michio, Physics of the Future, New York, et al.: Doubleday, 2011"
                },
                {
                    "path": "referent",
                    "from": null,
                    "to": "Creation"
                },
                {
                    "path": "structural_type",
                    "from": null,
                    "to": "Digital"
                },
                {
                    "path": "titles.0.lang",
                    "from": null,
                    "to": "en"
                },
                {
                    "path": "titles.0.type",
                    "from": null,
                    "to": "PrincipalTitle"
                },
                {
                    "path": "titles.0.value",
                    "from": null,
                    "to": "Review of Chemical, Pharmacological, Biological Activities of Isatin and Its Derivatives – Part-2 (2002 To 2020)"
                },
                {
                    "path": "type",
                    "from": null,
                    "to": "JournalArticle"
                }
            ],
            "record_after": {
                "format": "smartscholars-doi-metadata/1.0",
                "doi": "10.46243/jst.2020.v5.i4.pp288-307",
                "referent": "Creation",
                "type": "JournalArticle",
                "structural_type": "Digital",
                "modes": [
                    "Visual"
                ],
                "characters": [
                    "Language"
                ],
                "titles": [
                    {
                        "value": "Review of Chemical, Pharmacological, Biological Activities of Isatin and Its Derivatives – Part-2 (2002 To 2020)",
                        "type": "PrincipalTitle",
                        "lang": "en"
                    }
                ],
                "identifiers": [
                    {
                        "type": "DOI",
                        "value": "10.46243/jst.2020.v5.i4.pp288-307"
                    }
                ],
                "agents": [
                    {
                        "role": "author",
                        "name": {
                            "given": "",
                            "family": "Aditi Namboodiripad"
                        },
                        "sequence": "first"
                    },
                    {
                        "role": "author",
                        "name": {
                            "given": "",
                            "family": "Nimal C N"
                        },
                        "sequence": "additional"
                    },
                    {
                        "role": "publisher",
                        "name": {
                            "org": "Longman Publishers"
                        }
                    }
                ],
                "dates": {
                    "published": "2020-07-30",
                    "date_type": "PublicationDate",
                    "online": "2020-07-30"
                },
                "language": "en",
                "container": {
                    "type": "Journal",
                    "titles": [
                        {
                            "value": "Journal of Science &amp; Technology",
                            "type": "PrincipalTitle"
                        }
                    ],
                    "identifiers": [
                        {
                            "type": "ISSN",
                            "value": "2456-5660",
                            "medium": "electronic"
                        }
                    ],
                    "issue": "Volume 5",
                    "pages": {
                        "first": "288",
                        "last": "307"
                    }
                },
                "links": [
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/view/336",
                        "return_type": "text/html",
                        "primary": true
                    },
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/download/336/298",
                        "purpose": "text-mining",
                        "return_type": "application/pdf"
                    },
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/download/336/2501",
                        "purpose": "text-mining",
                        "return_type": "application/xml"
                    }
                ],
                "abstract": {
                    "value": ": Isatin is a naturally occurring substance identified in humans, animals, plants and coal tar. Isatin derivatives are reported to possess a wide range of activites. This review is in continuation of “Part-1 (1877-2002)” review published by our team. This review encompasses the most signigicant reports published during 2002 to 2020 on the biological & pharmacological activites of isatin and its derivatives. The review includes the various synthetic reactions of isatin and activites reported. The pharmacological and biological activites reported were antimicrobial, antineoplastic & related activities; analgesic, anti-inflammatory, anticonvulsant, antioxidant, activity against veterinary pathogen, effects on cardiac & vascular smooth muscles; transthyretin fibrillogenesis inhibitor and antiglycation activity of isatin compounds.",
                    "lang": "en"
                },
                "license": {
                    "url": "https://creativecommons.org/licenses/by/4.0",
                    "start": "2020-07-30",
                    "applies_to": "vor"
                },
                "references": [
                    {
                        "key": "ref1",
                        "unstructured": "Kardashev, N. S., “Transmission of information by Extraterrestrial c ivilizations,” Soviet Astronomy, Vol. 8, No. 2, Sept. -Oct. 1964"
                    },
                    {
                        "key": "ref2",
                        "unstructured": "Lamb, David, The Search for Extraterrestrial Intelligence: A Philosophical Inquiry, Routledge, London & New York, 2001, p. 182"
                    },
                    {
                        "key": "ref3",
                        "doi": "10.1093/acprof:oso/9780195171815.001.0001",
                        "unstructured": "Basalla, George, Civilized Life in the Universe: Scientists on Intelligent Extraterrestrials,Oxford University Press, Oxford, 2006, p. 148"
                    },
                    {
                        "key": "ref4",
                        "unstructured": "Sagan, Carl, The Cosmic Connection: An Extraterrestrial Perspective, Cambridge University Press, 2000, Part Three, Chapter 34"
                    },
                    {
                        "key": "ref5",
                        "unstructured": "Kaku, Michio, The Physics of the Impossible, New York, et al.: Doubleday, 2008, p. 145"
                    },
                    {
                        "key": "ref6",
                        "unstructured": "Kaku, Michio, Physics of the Future, New York, et al.: Doubleday, 2011"
                    }
                ],
                "record": {
                    "registrant": "Longman Publishers",
                    "registered": "2020-07-30",
                    "updated": "2026-09-26",
                    "issue_number": 1,
                    "source": "crossref-api",
                    "source_agency": "Crossref (member 25296)"
                }
            },
            "url_after": "https://www.jst.org.in/index.php/pub/article/view/336",
            "sha256_before": null,
            "sha256_after": "6ebefe88446c2211749ba5848fda6be4b7664a82245b3d0548c15c1ff56b1b75"
        },
        {
            "seq": 2,
            "kind": "update",
            "at": "2026-09-29 23:59:41",
            "by": "Administrator (admin)",
            "by_kind": "user",
            "note": "record re-read from api.crossref.org",
            "changes": [
                {
                    "path": "container.titles.0.value",
                    "from": "Journal of Science &amp; Technology",
                    "to": "Journal of Science & Technology"
                }
            ],
            "record_after": {
                "format": "smartscholars-doi-metadata/1.0",
                "doi": "10.46243/jst.2020.v5.i4.pp288-307",
                "referent": "Creation",
                "type": "JournalArticle",
                "structural_type": "Digital",
                "modes": [
                    "Visual"
                ],
                "characters": [
                    "Language"
                ],
                "titles": [
                    {
                        "value": "Review of Chemical, Pharmacological, Biological Activities of Isatin and Its Derivatives – Part-2 (2002 To 2020)",
                        "type": "PrincipalTitle",
                        "lang": "en"
                    }
                ],
                "identifiers": [
                    {
                        "type": "DOI",
                        "value": "10.46243/jst.2020.v5.i4.pp288-307"
                    }
                ],
                "agents": [
                    {
                        "role": "author",
                        "name": {
                            "given": "",
                            "family": "Aditi Namboodiripad"
                        },
                        "sequence": "first"
                    },
                    {
                        "role": "author",
                        "name": {
                            "given": "",
                            "family": "Nimal C N"
                        },
                        "sequence": "additional"
                    },
                    {
                        "role": "publisher",
                        "name": {
                            "org": "Longman Publishers"
                        }
                    }
                ],
                "dates": {
                    "published": "2020-07-30",
                    "date_type": "PublicationDate",
                    "online": "2020-07-30"
                },
                "language": "en",
                "container": {
                    "type": "Journal",
                    "titles": [
                        {
                            "value": "Journal of Science & Technology",
                            "type": "PrincipalTitle"
                        }
                    ],
                    "identifiers": [
                        {
                            "type": "ISSN",
                            "value": "2456-5660",
                            "medium": "electronic"
                        }
                    ],
                    "issue": "Volume 5",
                    "pages": {
                        "first": "288",
                        "last": "307"
                    }
                },
                "links": [
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/view/336",
                        "return_type": "text/html",
                        "primary": true
                    },
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/download/336/298",
                        "purpose": "text-mining",
                        "return_type": "application/pdf"
                    },
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/download/336/2501",
                        "purpose": "text-mining",
                        "return_type": "application/xml"
                    }
                ],
                "abstract": {
                    "value": ": Isatin is a naturally occurring substance identified in humans, animals, plants and coal tar. Isatin derivatives are reported to possess a wide range of activites. This review is in continuation of “Part-1 (1877-2002)” review published by our team. This review encompasses the most signigicant reports published during 2002 to 2020 on the biological & pharmacological activites of isatin and its derivatives. The review includes the various synthetic reactions of isatin and activites reported. The pharmacological and biological activites reported were antimicrobial, antineoplastic & related activities; analgesic, anti-inflammatory, anticonvulsant, antioxidant, activity against veterinary pathogen, effects on cardiac & vascular smooth muscles; transthyretin fibrillogenesis inhibitor and antiglycation activity of isatin compounds.",
                    "lang": "en"
                },
                "license": {
                    "url": "https://creativecommons.org/licenses/by/4.0",
                    "start": "2020-07-30",
                    "applies_to": "vor"
                },
                "references": [
                    {
                        "key": "ref1",
                        "unstructured": "Kardashev, N. S., “Transmission of information by Extraterrestrial c ivilizations,” Soviet Astronomy, Vol. 8, No. 2, Sept. -Oct. 1964"
                    },
                    {
                        "key": "ref2",
                        "unstructured": "Lamb, David, The Search for Extraterrestrial Intelligence: A Philosophical Inquiry, Routledge, London & New York, 2001, p. 182"
                    },
                    {
                        "key": "ref3",
                        "doi": "10.1093/acprof:oso/9780195171815.001.0001",
                        "unstructured": "Basalla, George, Civilized Life in the Universe: Scientists on Intelligent Extraterrestrials,Oxford University Press, Oxford, 2006, p. 148"
                    },
                    {
                        "key": "ref4",
                        "unstructured": "Sagan, Carl, The Cosmic Connection: An Extraterrestrial Perspective, Cambridge University Press, 2000, Part Three, Chapter 34"
                    },
                    {
                        "key": "ref5",
                        "unstructured": "Kaku, Michio, The Physics of the Impossible, New York, et al.: Doubleday, 2008, p. 145"
                    },
                    {
                        "key": "ref6",
                        "unstructured": "Kaku, Michio, Physics of the Future, New York, et al.: Doubleday, 2011"
                    }
                ],
                "record": {
                    "registrant": "Longman Publishers",
                    "registered": "2020-07-30",
                    "updated": "2026-09-26",
                    "issue_number": 1,
                    "source": "crossref-api",
                    "source_agency": "Crossref (member 25296)"
                }
            },
            "url_after": "https://www.jst.org.in/index.php/pub/article/view/336",
            "sha256_before": "6ebefe88446c2211749ba5848fda6be4b7664a82245b3d0548c15c1ff56b1b75",
            "sha256_after": "78f87e503f76e67abf96893a3e553972e16b8e33b3599e4679af61d4fb9c3ebd"
        }
    ]
}