{
    "ok": true,
    "doi": "10.46243/jst.2020.v5.i4.pp149-165",
    "events": [
        {
            "seq": 1,
            "kind": "register",
            "at": "2026-09-29 22:00:22",
            "by": "Administrator (admin)",
            "by_kind": "user",
            "note": "registered at Crossref; record read from api.crossref.org",
            "changes": [
                {
                    "path": "abstract.lang",
                    "from": null,
                    "to": "en"
                },
                {
                    "path": "abstract.value",
                    "from": null,
                    "to": ":Tranylcypromine is a drug used as antidepressant,anxiolytic, nonselective MAO A/B inhibitor. This drug is used to treat depression.The research was conducted to develop a polymeric micelle using a block copolymer, Pluronic F-68 and Gelucire 50/13 to improve the permeability of Tranylcypromine (TCP). A direct dissolution method was used to prepare polymeric micelles. The prepared micelles were characterised for particle size, % EE, zeta potential, in-vitro release. These micelles solution was used to prepare in situ gel by cold method in order to achieve controlled release. Central composite design was used for optimization of both polymeric micelles and insitu nasal gel.The main objective of this research work is to develop formulation acting centrally without undergoing first pass metabolism i.ie. directly nasal to brain delivery route."
                },
                {
                    "path": "agents.0.name.org",
                    "from": null,
                    "to": "Longman Publishers"
                },
                {
                    "path": "agents.0.role",
                    "from": null,
                    "to": "publisher"
                },
                {
                    "path": "characters.0",
                    "from": null,
                    "to": "Language"
                },
                {
                    "path": "container.identifiers.0.medium",
                    "from": null,
                    "to": "electronic"
                },
                {
                    "path": "container.identifiers.0.type",
                    "from": null,
                    "to": "ISSN"
                },
                {
                    "path": "container.identifiers.0.value",
                    "from": null,
                    "to": "2456-5660"
                },
                {
                    "path": "container.issue",
                    "from": null,
                    "to": "Volume 5"
                },
                {
                    "path": "container.pages.first",
                    "from": null,
                    "to": "149"
                },
                {
                    "path": "container.pages.last",
                    "from": null,
                    "to": "165"
                },
                {
                    "path": "container.titles.0.type",
                    "from": null,
                    "to": "PrincipalTitle"
                },
                {
                    "path": "container.titles.0.value",
                    "from": null,
                    "to": "Journal of Science &amp; Technology"
                },
                {
                    "path": "container.type",
                    "from": null,
                    "to": "Journal"
                },
                {
                    "path": "dates.date_type",
                    "from": null,
                    "to": "PublicationDate"
                },
                {
                    "path": "dates.online",
                    "from": null,
                    "to": "2020-07-30"
                },
                {
                    "path": "dates.published",
                    "from": null,
                    "to": "2020-07-30"
                },
                {
                    "path": "doi",
                    "from": null,
                    "to": "10.46243/jst.2020.v5.i4.pp149-165"
                },
                {
                    "path": "format",
                    "from": null,
                    "to": "smartscholars-doi-metadata/1.0"
                },
                {
                    "path": "identifiers.0.type",
                    "from": null,
                    "to": "DOI"
                },
                {
                    "path": "identifiers.0.value",
                    "from": null,
                    "to": "10.46243/jst.2020.v5.i4.pp149-165"
                },
                {
                    "path": "language",
                    "from": null,
                    "to": "en"
                },
                {
                    "path": "license.applies_to",
                    "from": null,
                    "to": "vor"
                },
                {
                    "path": "license.start",
                    "from": null,
                    "to": "2020-07-30"
                },
                {
                    "path": "license.url",
                    "from": null,
                    "to": "https://creativecommons.org/licenses/by/4.0"
                },
                {
                    "path": "links.0.primary",
                    "from": null,
                    "to": true
                },
                {
                    "path": "links.0.return_type",
                    "from": null,
                    "to": "text/html"
                },
                {
                    "path": "links.0.url",
                    "from": null,
                    "to": "https://www.jst.org.in/index.php/pub/article/view/336"
                },
                {
                    "path": "links.1.purpose",
                    "from": null,
                    "to": "text-mining"
                },
                {
                    "path": "links.1.return_type",
                    "from": null,
                    "to": "application/pdf"
                },
                {
                    "path": "links.1.url",
                    "from": null,
                    "to": "https://www.jst.org.in/index.php/pub/article/download/336/298"
                },
                {
                    "path": "links.2.purpose",
                    "from": null,
                    "to": "text-mining"
                },
                {
                    "path": "links.2.return_type",
                    "from": null,
                    "to": "application/xml"
                },
                {
                    "path": "links.2.url",
                    "from": null,
                    "to": "https://www.jst.org.in/index.php/pub/article/download/336/2501"
                },
                {
                    "path": "modes.0",
                    "from": null,
                    "to": "Visual"
                },
                {
                    "path": "record.issue_number",
                    "from": null,
                    "to": 1
                },
                {
                    "path": "record.registered",
                    "from": null,
                    "to": "2020-07-30"
                },
                {
                    "path": "record.registrant",
                    "from": null,
                    "to": "Longman Publishers"
                },
                {
                    "path": "record.source",
                    "from": null,
                    "to": "crossref-api"
                },
                {
                    "path": "record.source_agency",
                    "from": null,
                    "to": "Crossref (member 25296)"
                },
                {
                    "path": "record.updated",
                    "from": null,
                    "to": "2026-09-26"
                },
                {
                    "path": "references.0.key",
                    "from": null,
                    "to": "ref1"
                },
                {
                    "path": "references.0.unstructured",
                    "from": null,
                    "to": "Kardashev, N. S., “Transmission of information by Extraterrestrial c ivilizations,” Soviet Astronomy, Vol. 8, No. 2, Sept. -Oct. 1964"
                },
                {
                    "path": "references.1.key",
                    "from": null,
                    "to": "ref2"
                },
                {
                    "path": "references.1.unstructured",
                    "from": null,
                    "to": "Lamb, David, The Search for Extraterrestrial Intelligence: A Philosophical Inquiry, Routledge, London & New York, 2001, p. 182"
                },
                {
                    "path": "references.2.doi",
                    "from": null,
                    "to": "10.1093/acprof:oso/9780195171815.001.0001"
                },
                {
                    "path": "references.2.key",
                    "from": null,
                    "to": "ref3"
                },
                {
                    "path": "references.2.unstructured",
                    "from": null,
                    "to": "Basalla, George, Civilized Life in the Universe: Scientists on Intelligent Extraterrestrials,Oxford University Press, Oxford, 2006, p. 148"
                },
                {
                    "path": "references.3.key",
                    "from": null,
                    "to": "ref4"
                },
                {
                    "path": "references.3.unstructured",
                    "from": null,
                    "to": "Sagan, Carl, The Cosmic Connection: An Extraterrestrial Perspective, Cambridge University Press, 2000, Part Three, Chapter 34"
                },
                {
                    "path": "references.4.key",
                    "from": null,
                    "to": "ref5"
                },
                {
                    "path": "references.4.unstructured",
                    "from": null,
                    "to": "Kaku, Michio, The Physics of the Impossible, New York, et al.: Doubleday, 2008, p. 145"
                },
                {
                    "path": "references.5.key",
                    "from": null,
                    "to": "ref6"
                },
                {
                    "path": "references.5.unstructured",
                    "from": null,
                    "to": "Kaku, Michio, Physics of the Future, New York, et al.: Doubleday, 2011"
                },
                {
                    "path": "referent",
                    "from": null,
                    "to": "Creation"
                },
                {
                    "path": "structural_type",
                    "from": null,
                    "to": "Digital"
                },
                {
                    "path": "titles.0.lang",
                    "from": null,
                    "to": "en"
                },
                {
                    "path": "titles.0.type",
                    "from": null,
                    "to": "PrincipalTitle"
                },
                {
                    "path": "titles.0.value",
                    "from": null,
                    "to": "Formulation and Characterization of Tranylcypromine loaded\nPolymeric Micellar In-Situ Nasal Gel for treatment of Depression"
                },
                {
                    "path": "type",
                    "from": null,
                    "to": "JournalArticle"
                }
            ],
            "record_after": {
                "format": "smartscholars-doi-metadata/1.0",
                "doi": "10.46243/jst.2020.v5.i4.pp149-165",
                "referent": "Creation",
                "type": "JournalArticle",
                "structural_type": "Digital",
                "modes": [
                    "Visual"
                ],
                "characters": [
                    "Language"
                ],
                "titles": [
                    {
                        "value": "Formulation and Characterization of Tranylcypromine loaded\nPolymeric Micellar In-Situ Nasal Gel for treatment of Depression",
                        "type": "PrincipalTitle",
                        "lang": "en"
                    }
                ],
                "identifiers": [
                    {
                        "type": "DOI",
                        "value": "10.46243/jst.2020.v5.i4.pp149-165"
                    }
                ],
                "agents": [
                    {
                        "role": "publisher",
                        "name": {
                            "org": "Longman Publishers"
                        }
                    }
                ],
                "dates": {
                    "published": "2020-07-30",
                    "date_type": "PublicationDate",
                    "online": "2020-07-30"
                },
                "language": "en",
                "container": {
                    "type": "Journal",
                    "titles": [
                        {
                            "value": "Journal of Science &amp; Technology",
                            "type": "PrincipalTitle"
                        }
                    ],
                    "identifiers": [
                        {
                            "type": "ISSN",
                            "value": "2456-5660",
                            "medium": "electronic"
                        }
                    ],
                    "issue": "Volume 5",
                    "pages": {
                        "first": "149",
                        "last": "165"
                    }
                },
                "links": [
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/view/336",
                        "return_type": "text/html",
                        "primary": true
                    },
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/download/336/298",
                        "purpose": "text-mining",
                        "return_type": "application/pdf"
                    },
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/download/336/2501",
                        "purpose": "text-mining",
                        "return_type": "application/xml"
                    }
                ],
                "abstract": {
                    "value": ":Tranylcypromine is a drug used as antidepressant,anxiolytic, nonselective MAO A/B inhibitor. This drug is used to treat depression.The research was conducted to develop a polymeric micelle using a block copolymer, Pluronic F-68 and Gelucire 50/13 to improve the permeability of Tranylcypromine (TCP). A direct dissolution method was used to prepare polymeric micelles. The prepared micelles were characterised for particle size, % EE, zeta potential, in-vitro release. These micelles solution was used to prepare in situ gel by cold method in order to achieve controlled release. Central composite design was used for optimization of both polymeric micelles and insitu nasal gel.The main objective of this research work is to develop formulation acting centrally without undergoing first pass metabolism i.ie. directly nasal to brain delivery route.",
                    "lang": "en"
                },
                "license": {
                    "url": "https://creativecommons.org/licenses/by/4.0",
                    "start": "2020-07-30",
                    "applies_to": "vor"
                },
                "references": [
                    {
                        "key": "ref1",
                        "unstructured": "Kardashev, N. S., “Transmission of information by Extraterrestrial c ivilizations,” Soviet Astronomy, Vol. 8, No. 2, Sept. -Oct. 1964"
                    },
                    {
                        "key": "ref2",
                        "unstructured": "Lamb, David, The Search for Extraterrestrial Intelligence: A Philosophical Inquiry, Routledge, London & New York, 2001, p. 182"
                    },
                    {
                        "key": "ref3",
                        "doi": "10.1093/acprof:oso/9780195171815.001.0001",
                        "unstructured": "Basalla, George, Civilized Life in the Universe: Scientists on Intelligent Extraterrestrials,Oxford University Press, Oxford, 2006, p. 148"
                    },
                    {
                        "key": "ref4",
                        "unstructured": "Sagan, Carl, The Cosmic Connection: An Extraterrestrial Perspective, Cambridge University Press, 2000, Part Three, Chapter 34"
                    },
                    {
                        "key": "ref5",
                        "unstructured": "Kaku, Michio, The Physics of the Impossible, New York, et al.: Doubleday, 2008, p. 145"
                    },
                    {
                        "key": "ref6",
                        "unstructured": "Kaku, Michio, Physics of the Future, New York, et al.: Doubleday, 2011"
                    }
                ],
                "record": {
                    "registrant": "Longman Publishers",
                    "registered": "2020-07-30",
                    "updated": "2026-09-26",
                    "issue_number": 1,
                    "source": "crossref-api",
                    "source_agency": "Crossref (member 25296)"
                }
            },
            "url_after": "https://www.jst.org.in/index.php/pub/article/view/336",
            "sha256_before": null,
            "sha256_after": "13062c666151adfbe522a58ec42ddcbe91d6ee7f9e8197761c73251e7a57e582"
        },
        {
            "seq": 2,
            "kind": "update",
            "at": "2026-09-29 23:59:41",
            "by": "Administrator (admin)",
            "by_kind": "user",
            "note": "record re-read from api.crossref.org",
            "changes": [
                {
                    "path": "container.titles.0.value",
                    "from": "Journal of Science &amp; Technology",
                    "to": "Journal of Science & Technology"
                },
                {
                    "path": "titles.0.value",
                    "from": "Formulation and Characterization of Tranylcypromine loaded\nPolymeric Micellar In-Situ Nasal Gel for treatment of Depression",
                    "to": "Formulation and Characterization of Tranylcypromine loaded Polymeric Micellar In-Situ Nasal Gel for treatment of Depression"
                }
            ],
            "record_after": {
                "format": "smartscholars-doi-metadata/1.0",
                "doi": "10.46243/jst.2020.v5.i4.pp149-165",
                "referent": "Creation",
                "type": "JournalArticle",
                "structural_type": "Digital",
                "modes": [
                    "Visual"
                ],
                "characters": [
                    "Language"
                ],
                "titles": [
                    {
                        "value": "Formulation and Characterization of Tranylcypromine loaded Polymeric Micellar In-Situ Nasal Gel for treatment of Depression",
                        "type": "PrincipalTitle",
                        "lang": "en"
                    }
                ],
                "identifiers": [
                    {
                        "type": "DOI",
                        "value": "10.46243/jst.2020.v5.i4.pp149-165"
                    }
                ],
                "agents": [
                    {
                        "role": "publisher",
                        "name": {
                            "org": "Longman Publishers"
                        }
                    }
                ],
                "dates": {
                    "published": "2020-07-30",
                    "date_type": "PublicationDate",
                    "online": "2020-07-30"
                },
                "language": "en",
                "container": {
                    "type": "Journal",
                    "titles": [
                        {
                            "value": "Journal of Science & Technology",
                            "type": "PrincipalTitle"
                        }
                    ],
                    "identifiers": [
                        {
                            "type": "ISSN",
                            "value": "2456-5660",
                            "medium": "electronic"
                        }
                    ],
                    "issue": "Volume 5",
                    "pages": {
                        "first": "149",
                        "last": "165"
                    }
                },
                "links": [
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/view/336",
                        "return_type": "text/html",
                        "primary": true
                    },
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/download/336/298",
                        "purpose": "text-mining",
                        "return_type": "application/pdf"
                    },
                    {
                        "url": "https://www.jst.org.in/index.php/pub/article/download/336/2501",
                        "purpose": "text-mining",
                        "return_type": "application/xml"
                    }
                ],
                "abstract": {
                    "value": ":Tranylcypromine is a drug used as antidepressant,anxiolytic, nonselective MAO A/B inhibitor. This drug is used to treat depression.The research was conducted to develop a polymeric micelle using a block copolymer, Pluronic F-68 and Gelucire 50/13 to improve the permeability of Tranylcypromine (TCP). A direct dissolution method was used to prepare polymeric micelles. The prepared micelles were characterised for particle size, % EE, zeta potential, in-vitro release. These micelles solution was used to prepare in situ gel by cold method in order to achieve controlled release. Central composite design was used for optimization of both polymeric micelles and insitu nasal gel.The main objective of this research work is to develop formulation acting centrally without undergoing first pass metabolism i.ie. directly nasal to brain delivery route.",
                    "lang": "en"
                },
                "license": {
                    "url": "https://creativecommons.org/licenses/by/4.0",
                    "start": "2020-07-30",
                    "applies_to": "vor"
                },
                "references": [
                    {
                        "key": "ref1",
                        "unstructured": "Kardashev, N. S., “Transmission of information by Extraterrestrial c ivilizations,” Soviet Astronomy, Vol. 8, No. 2, Sept. -Oct. 1964"
                    },
                    {
                        "key": "ref2",
                        "unstructured": "Lamb, David, The Search for Extraterrestrial Intelligence: A Philosophical Inquiry, Routledge, London & New York, 2001, p. 182"
                    },
                    {
                        "key": "ref3",
                        "doi": "10.1093/acprof:oso/9780195171815.001.0001",
                        "unstructured": "Basalla, George, Civilized Life in the Universe: Scientists on Intelligent Extraterrestrials,Oxford University Press, Oxford, 2006, p. 148"
                    },
                    {
                        "key": "ref4",
                        "unstructured": "Sagan, Carl, The Cosmic Connection: An Extraterrestrial Perspective, Cambridge University Press, 2000, Part Three, Chapter 34"
                    },
                    {
                        "key": "ref5",
                        "unstructured": "Kaku, Michio, The Physics of the Impossible, New York, et al.: Doubleday, 2008, p. 145"
                    },
                    {
                        "key": "ref6",
                        "unstructured": "Kaku, Michio, Physics of the Future, New York, et al.: Doubleday, 2011"
                    }
                ],
                "record": {
                    "registrant": "Longman Publishers",
                    "registered": "2020-07-30",
                    "updated": "2026-09-26",
                    "issue_number": 1,
                    "source": "crossref-api",
                    "source_agency": "Crossref (member 25296)"
                }
            },
            "url_after": "https://www.jst.org.in/index.php/pub/article/view/336",
            "sha256_before": "13062c666151adfbe522a58ec42ddcbe91d6ee7f9e8197761c73251e7a57e582",
            "sha256_after": "a4df91e2990256ea1fd7cb37d52a5a197d7f32a32e43c58dd371dfe73905bb56"
        }
    ]
}